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Association between adherence to Mediterranean-DASH intervention for neurodegenerative delay diet and disease severity in patients with ulcerative colitis
Publication Year: 2025 Source: Sci Rep PMID: 40595032
Considering the importance of induction and maintenance of remission in patients with ulcerative colitis (UC), different studies investigated the association between adherence to healthy dietary patterns and disease severity. This cross-sectional study investigated the association between Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet score and disease severity in patients with …
Neutrophil-mediated degradation of type III collagen is elevated in inflammatory bowel disease and DSS-induced colitis reflecting early mucosal damage
Publication Year: 2025 Source: Sci Rep PMID: 40595355 DOI: 10.1038/s41598-025-09043-6
Inflammatory Bowel Disease (IBD) is characterized by mucosal injury in the gastrointestinal (GI) tract. During an abnormal immune response in the GI tract, excessive secretion of immune-cell proteases occurs. Neutrophils are the first responders, infiltrating into the inflamed interstitial matrix, where type III collagen accumulates. We aimed to develop a …
Oxidative stress gene expression in ulcerative colitis: implications for colon cancer biomarker discovery
Publication Year: 2025 Source: Sci Rep PMID: 40595862
There is a complex interrelationship between colorectal cancer (CRC) and ulcerative colitis (UC). This study aimed to identify key molecules and pathways involved in the co-occurrence of CRC and UC, as well as the role of oxidative stress in disease progression, through bioinformatics analysis of public RNA sequencing databases. We …
Mesenteric adipose tissue in Crohn's disease alters the immune response of the ileal mucosa and increases angiogenesis and fibrosis
Publication Year: 2025 Source: Sci Rep PMID: 40596617
Mesenteric adipose tissue (MAT) may be involved in the pathogenesis of Crohn's disease (CD). However, its precise role remains uncertain. We analize the profile of molecules secreted by the MAT (secretome) in CD, differentiating between 'creeping fat' (CD-CrF) and the MAT obtained from a non-affected area (CD-NA), and to characterise …
EXPRESS: Gender-Specific Effects of Appendectomy on Inflammatory Bowel Disease: Increased Odds of Crohn's Disease and Decreased Odds of Ulcerative Colitis in Women-An Analysis Using the National Inpatient Sample
Publication Year: 2025 Source: J Investig Med PMID: 40596739 DOI: 10.1177/10815589251347188
This study investigates the gender-specific and demographic associations of appendectomy on the concurrent diagnosis of inflammatory bowel disease (IBD), using data from the National Inpatient Sample (NIS) (2018-2021) comprising 25,950,053 hospitalized patients. Among the cohort, there were a total of 1,207,569 patients who underwent an appendectomy during the hospitalization. Similarly, …
Gut microbial Nordihydroguaiaretic acid suppresses macrophage pyroptosis to regulate epithelial homeostasis and inflammation
Publication Year: 2025 Source: Gut Microbes PMID: 40596758 DOI: 10.1080/19490976.2025.2518338
BACKGROUND: Aging is associated with increased severity of inflammatory bowel disease (IBD). Gut senescence and altered environmental factors contribute to changes in the intestinal metabolome, particularly in frail older individuals. However, the role of age-associated dysbiosis, characterized by a decline in beneficial gut microbiota and their metabolites, in exacerbating IBD …
Impact of terminal ileal microbiota dysbiosis and tryptophan metabolism alterations on mental disorders in patients with Crohn's disease
Publication Year: 2025 Source: BMC Gastroenterol PMID: 40596914
BACKGROUND: Crohn's disease (CD) is a chronic non-specific inflammatory bowel disease with an increasing incidence worldwide. Patients with CD are facing elevated risk for mental disorders (MD) than healthy people, and chronic psychological stress is considered to trigger deterioration and relapse of CD. The microbiome-gut-brain axis (MGBA) is recognized as …
Development and validation of a nomogram for predicting endoscopic healing in crohn's disease patients receiving infliximab treatment
Publication Year: 2025 Source: BMC Gastroenterol PMID: 40596918
OBJECTIVE: The objective of this study was to identify prognostic clinicopathological factors in patients with Crohn's disease (CD) receiving infliximab (IFX) treatment and to develop a new nomogram for predicting outcomes in this population. METHODS: The primary outcome was endoscopic healing (EH) in CD patients receiving IFX at week 30. …
Crohn's disease onset associated with a ballistic injury to the abdomen in the patient wounded in the war in Ukraine: a case report
Publication Year: 2025 Source: J Med Case Rep PMID: 40597211
BACKGROUND: The Russo-Ukrainian war is ongoing warfare that is associated with severe injuries among the civil population and military personnel. The aim of this study was to demonstrate a rare case of Crohn's disease manifestation in a combat patient in relation to a ballistic injury to the abdomen in the …
Psychometric properties of the Hungarian Visceral Sensitivity Index (VSI-H): insights from two cross-sectional studies on self-reported IBS and gluten-related conditions
Publication Year: 2025 Source: BMC Psychol PMID: 40597234
BACKGROUND: The present study examines the role of gastrointestinal symptom-specific anxiety in gluten-related conditions (e.g., celiac disease, non-coeliac gluten sensitivity) and in irritable bowel syndrome (IBS). The Visceral Sensitivity Index is widely used instrument for assessing gastrointestinal symptom-specific anxiety, originally used among IBS individuals, but it proved applicable to other …
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