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The Potential of Cannabis in Managing Inflammatory Bowel Disease and Its Future Perspective
Publication Year: 2024 Source: Cureus PMID: 39624503 DOI: 10.7759/cureus.71068
Inflammatory bowel disease (IBD) is an inflammation of the gastrointestinal tract mainly categorized as Crohn's disease and ulcerative colitis. The current management of IBD includes pharmacological, surgical, psychological, and complementary treatments, but cannabis effects are also becoming more popular as complementary therapies. Cannabinoids act on two G-protein coupled receptors, CB1 …
De Novo Kaposi Sarcoma in an HIV-Negative Liver Transplant Recipient With Ulcerative Colitis and Primary Sclerosing Cholangitis
Publication Year: 2024 Source: Case Rep Transplant PMID: 39624666 DOI: 10.1155/crit/4699128
De novo or viral reactivation cancers are a major cause of morbidity and mortality in the solid organ transplant (SOT) population. Primary sclerosing cholangitis (PSC) is an aggressive disease which can lead to cholestatic liver damage and cirrhosis. PSC often cooccurs with inflammatory bowel disease (IBD). Here, we describe the …
Immunomodulatory Effects of Lactiplantibacillus plantarum Strain RW1 During Salmonella Infection in Murine Intestinal Epithelial Cells and Dextran Sulfate Sodium-Induced Murine Colitis
Publication Year: 2024 Source: Probiotics Antimicrob Proteins PMID: 39625595
No Abstract
How fast are viruses spreading in the wild?
Publication Year: 2024 Source: PLoS Biol PMID: 39625970 DOI: 10.1371/journal.pbio.3002914
Genomic data collected from viral outbreaks can be exploited to reconstruct the dispersal history of viral lineages in a two-dimensional space using continuous phylogeographic inference. These spatially explicit reconstructions can subsequently be used to estimate dispersal metrics that can be informative of the dispersal dynamics and the capacity to spread …
Correction to: Utilization of Treat-to-Target Monitoring Colonoscopy After Treatment Initiation in the US-Based Study of a Prospective Adult Research Cohort With Inflammatory Bowel Disease
Publication Year: 2024 Source: Am J Gastroenterol PMID: 39626067 DOI: 10.14309/ajg.0000000000002650
No Abstract
Chemical activation of mitochondrial ClpP to modulate energy metabolism of CD4(+) T cell for inflammatory bowel diseases treatment
Publication Year: 2024 Source: Cell Rep Med PMID: 39626672 DOI: 10.1016/j.xcrm.2024.101840
Inflammatory bowel disease (IBD) is an autoimmune disorder, and despite the availability of multiple Food and Drug Administration (FDA)-approved therapies, current clinical needs remain unmet. In this study, we find that caseinolytic protease P (ClpP) expression is markedly upregulated in colonic tissues from IBD patients and preclinical colitis models, particularly …
Anti-CdtB and anti-vinculin antibodies to diagnose irritable bowel syndrome in inflammatory bowel disease patients
Publication Year: 2024 Source: BMC Gastroenterol PMID: 39627697 DOI: 10.1186/s12876-024-03509-z
BACKGROUND: Despite adequate treatment, a subgroup of patients with inflammatory bowel disease (IBD), including Crohn;s disease and ulcerative colitis, have persistent gastrointestinal symptoms that are not always related to mucosal damage. Recently, two autoantibodies, anti-CdtB and anti-vinculin, were validated as post-infectious IBS (PI-IBS) markers, however there is limited evidence of …
Genetically engineered bacteria as inflammatory bowel disease therapeutics
Publication Year: 2024 Source: Eng Microbiol PMID: 39628589 DOI: 10.1016/j.engmic.2024.100167
Inflammatory bowel disease (IBD) is a chronic and recurrent disease caused by immune response disorders that disrupt the intestinal lumen symbiotic ecosystem and dysregulate mucosal immune functions. Current therapies available for IBD primarily focus on symptom management, making early diagnosis and prompt intervention challenging. The development of genetically engineered bacteria …
A Study of Small and Large Bowel Wall Thickness Using Computed Tomography and Its Histopathological Correlation
Publication Year: 2024 Source: Cureus PMID: 39628742 DOI: 10.7759/cureus.72932
BACKGROUND: Small bowel imaging presents significant challenges due to the bowel's length, narrow caliber, and complex looping. Accurate diagnosis of gastrointestinal disorders often requires detailed imaging to differentiate various pathologies, such as inflammatory bowel disease (IBD), infections, ischemic conditions, and neoplasms. INTRODUCTION: The small bowel plays a crucial role in …
Novel approach to assess sarcopenia in children with inflammatory bowel disease
Publication Year: 2024 Source: Front Pediatr PMID: 39629099 DOI: 10.3389/fped.2024.1204639
INTRODUCTION: Sarcopenia is associated with poor clinical outcomes in chronic diseases. Our study aimed to characterize body composition (BC) parameters in patients with inflammatory bowel disease (IBD) and compare skeletal muscle mass (SMM) parameters with the healthy pediatric population. METHODS: BC of healthy controls (HC) and of patients with IBD …
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