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Oxidative stress-related biomarkers as promising indicators of inflammatory bowel disease activity: A systematic review and meta-analysis

Publication Year: 2024 Source: Redox Biol PMID: 39368456 DOI: 10.1016/j.redox.2024.103380

Oxidative stress is believed to play an important role in the pathogenesis of inflammatory bowel disease (IBD), specifically Crohn's disease (CD) and ulcerative colitis (UC). This meta-analysis aimed to identify and quantify the oxidative stress-related biomarkers in IBD and their associations with disease activity. We systematically searched Ovid MEDLINE, Ovid …

Opuntia ficus-indica cladodes extract inhibits human neutrophil pro-inflammatory functions and protects rats from acetic acid-induced ulcerative colitis

Publication Year: 2024 Source: Inflammopharmacology PMID: 39369123 DOI: 10.1007/s10787-024-01577-x

The increased production of reactive oxygen species (ROS) by human neutrophils can lead to oxidative imbalances and several diseases, such as inflammatory bowel disease (IBD). Opuntia ficus-indica (O. ficus-indica) is rich in bioactive substances with anti-inflammatory properties. This study aimed to identify the bioactive compounds present in aqueous cladodes extract …

Pharmacodynamic and pharmacokinetic study of Shaoyao Gancao decoction for repairing intestinal barrier damage in ulcerative colitis

Publication Year: 2024 Source: Mol Immunol PMID: 39369520

No Abstract

Interferon regulatory factor 7 alleviates the experimental colitis through enhancing IL-28A-mediated intestinal epithelial integrity

Publication Year: 2024 Source: J Transl Med PMID: 39370517 DOI: 10.1186/s12967-024-05673-y

BACKGROUND: The incidence of inflammatory bowel disease (IBD) is on the rise in developing countries, and investigating the underlying mechanisms of IBD is essential for the development of targeted therapeutic interventions. Interferon regulatory factor 7 (IRF7) is known to exert pro-inflammatory effects in various autoimmune diseases, yet its precise role …

Impact of inflammatory bowel diseases on the intimate lives of youths: Creating a brief screening questionnaire

Publication Year: 2024 Source: J Pediatr Gastroenterol Nutr PMID: 39370815 DOI: 10.1002/jpn3.12379

OBJECTIVES: The objectives were to describe the challenges faced by youths with inflammatory bowel disease (IBD) in their intimate lives before the onset of sexual activity and develop a screening tool to detect early difficulties. METHODS: We conducted a cross-sectional qualitative study via semi-structured interviews with 15-19-year-olds diagnosed with IBD. …

A pilot study to identify blood-based markers associated with response to treatment with Vedolizumab in patients with Inflammatory Bowel Disease

Publication Year: 2024 Source: medRxiv PMID: 39371119 DOI: 10.1101/2024.09.19.24314034

The inflammatory bowel diseases (IBD) known as Crohn's disease (CD) and ulcerative colitis (UC) are chronic inflammatory diseases of the gastrointestinal tract believed to arise because of an imbalance between the epithelial, immune and microbial systems. It has been shown that biological differences (genetic, epigenetic, microbial, environmental, etc.) exist between …

Gut microbiome shifts in adolescents after sleeve gastrectomy with increased oral-associated taxa and pro-inflammatory potential

Publication Year: 2024 Source: medRxiv PMID: 39371172

No Abstract

Probiotic Lactiplantibacillus plantarum subsp. plantarum Dad-13 Alleviates 2,4,6-Trinitrobenzene Sulfonic Acid-Induced Colitis Through Short-Chain Fatty Acid Production and Inflammatory Cytokine Regulation

Publication Year: 2024 Source: Prev Nutr Food Sci PMID: 39371515 DOI: 10.3746/pnf.2024.29.3.270

The development of inflammatory bowel disease (IBD) is closely linked to inflammatory damage and dysbiosis. Recently, probiotics are being increasingly used to improve intestinal health. Probiotic-based therapies can prevent IBD by restoring the balance of gastrointestinal microbiota, reducing gut inflammation, and increasing the concentration of short-chain fatty acids (SCFAs). The …

Pancreatic Heterotopia Presenting as a Mimic of Fistulizing Crohn's Disease: Expanding the Differential Diagnosis of Inflammatory Bowel Disease

Publication Year: 2024 Source: Cureus PMID: 39371867 DOI: 10.7759/cureus.68666

Pancreatic heterotopia (PH) involves pancreatic tissue located outside its typical anatomical position, lacking vascular or ductal communication with the pancreas. Despite frequently having acini with the capacity to produce digestive enzymes, PH is usually asymptomatic. When symptoms do occur, they typically present in middle to late adulthood and include abdominal …

Patient-Reported Racial and Ethnic Disparities in Patients With Ulcerative Colitis: Results From the National Health and Wellness Survey

Publication Year: 2024 Source: Crohns Colitis 360 PMID: 39372097

No Abstract

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