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Gut microbiome therapy: fecal microbiota transplantation vs live biotherapeutic products
Publication Year: 2024 Source: Gut Microbes PMID: 39377231 DOI: 10.1080/19490976.2024.2412376
The human intestine hosts a complex ecosystem of various microorganisms, collectively known as the gut microbiome, which significantly impacts human health. Disruptions in the gut microbiome are linked to various disorders, including gastrointestinal diseases, such as Clostridioides difficile infection and inflammatory bowel disease, as well as metabolic, neurological, oncologic conditions. …
An Open Letter to the Food and Drug Administration and Pharmaceutical Industry Concerning Drug Approval for Children With Inflammatory Bowel Disease
Publication Year: 2024 Source: Inflamm Bowel Dis PMID: 39377256 DOI: 10.1093/ibd/izae226
No Abstract
Healthcare Access for Patients With Inflammatory Bowel Disease in the United States: A Survey by the Crohn's & Colitis Foundation
Publication Year: 2024 Source: Inflamm Bowel Dis PMID: 39377748 DOI: 10.1093/ibd/izae237
BACKGROUND: A prior survey disseminated in 2017 identified that healthcare access barriers exist and significantly affect patients with inflammatory bowel disease (IBD). We sought to identify, through an updated survey, the healthcare access barriers that patients continue to face, with a focus on socioeconomic factors and patient awareness of resources …
Inhibition of intestinal inflammation and fibrosis by Scutellaria Baicalensis georgi and Boswellia serrata in human epithelial cells and fibroblasts
Publication Year: 2024 Source: Immun Inflamm Dis PMID: 39377749 DOI: 10.1002/iid3.70036
OBJECTIVE AND RATIONALE: Inflammatory bowel disease, including Crohn's disease and ulcerative colitis, manifests with chronic intestinal inflammation and frequent sequential fibrosis. Current pharmacological therapies may show harmful side effects and are not useful for prevention or resolution of fibrosis. Thus, the use of alternative therapies is emerging as a novel …
Human Amniotic Epithelial Stem Cells Promote Colonic Recovery in Experimental Colitis via Exosomal MiR-23a-TNFR1-NF-κB Signaling
Publication Year: 2024 Source: Adv Sci (Weinh) PMID: 39378064 DOI: 10.1002/advs.202401429
Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, manifests as chronic intestinal inflammation with debilitating symptoms, posing a significant burden on global healthcare. Moreover, current therapies primarily targeting inflammation can lead to immunosuppression-related complications. Human amniotic epithelial stem cells (hAESCs), which exhibit low immunogenicity and ethical acceptability, have …
Novel selenium-enriched Pichia kudriavzevii as a dietary supplement to alleviate dextran sulfate sodium-induced colitis in mice by modulating the gut microbiota and host metabolism
Publication Year: 2024 Source: Food Funct PMID: 39378068 DOI: 10.1039/d4fo02598a
Inflammatory bowel disease (IBD) poses persistent challenges due to its chronic and recurrent nature, exacerbated by the unsatisfactory outcomes of the traditional treatment approaches. In this study, we developed a dietary supplement, selenium-enriched Pichia kudriavzevii (SeY), to alleviate dextran sulfate sodium-induced colitis in mice. The newly developed functional food shows …
Alleviation of colitis by honeysuckle MIR2911 via direct regulation of gut microbiota
Publication Year: 2024 Source: J Control Release PMID: 39378978 DOI: 10.1016/j.jconrel.2024.09.050
Inflammatory bowel disease (IBD) is a group of chronic relapsing diseases associated with inflammatory disorders and microbial dysbiosis of the intestine. The use of traditional Chinese medicine (TCM) to treat colitis has the advantage of fewer side effects, but the molecular mechanism is not clear. Recently, miRNAs have been recognized …
Type 17 immunity: novel insights into intestinal homeostasis and autoimmune pathogenesis driven by gut-primed T cells
Publication Year: 2024 Source: Cell Mol Immunol PMID: 39379604 DOI: 10.1038/s41423-024-01218-x
The IL-23 signaling pathway in both innate and adaptive immune cells is vital for orchestrating type 17 immunity, which is marked by the secretion of signature cytokines such as IL-17, IL-22, and GM-CSF. These proinflammatory mediators play indispensable roles in maintaining intestinal immune equilibrium and mucosal host defense; however, their …
Advancements in Colon-Targeted Drug Delivery: A Comprehensive Review on Recent Techniques with Emphasis on Hot-Melt Extrusion and 3D Printing Technologies
Publication Year: 2024 Source: AAPS PharmSciTech PMID: 39379609
No Abstract
Interpreting modern randomized controlled trials of medical therapy in inflammatory bowel disease
Publication Year: 2024 Source: Nat Rev Gastroenterol Hepatol PMID: 39379665 DOI: 10.1038/s41575-024-00989-y
Treatment options for the medical management of inflammatory bowel disease (IBD) have expanded substantially over the past decade. Multiple classes of advanced therapies, including both monoclonal antibodies and novel oral small molecules, are now available for the treatment of moderately-to-severely active Crohn's disease and ulcerative colitis, highlighted by the approvals …
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