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Oxytocin Analogues for the Oral Treatment of Abdominal Pain
Publication Year: 2024 Source: Angew Chem Int Ed Engl PMID: 39384545 DOI: 10.1002/anie.202415333
Abdominal pain presents an onerous reality for millions of people affected by gastrointestinal disorders such as irritable bowel syndrome (IBS) and inflammatory bowel diseases (IBD). The oxytocin receptor (OTR) has emerged as a new analgesic drug target with OTR expression upregulated on colon-innervating nociceptors in chronic visceral hypersensitivity states, accessible …
Outcomes of robotic surgery for inflammatory bowel disease using the Medtronic Hugo™ Robotic-Assisted Surgical platform: a single center experience
Publication Year: 2024 Source: Int J Colorectal Dis PMID: 39384631 DOI: 10.1007/s00384-024-04736-2
PURPOSE: The aim of the study was to compare the perioperative outcomes of patients affected by inflammatory bowel disease (IBD) who underwent surgery performed through laparoscopy or using the Medtronic Hugo RAS. METHODS: This is a retrospective study from a prospectively maintained database comparing laparoscopic vs. robotic-assisted surgery for IBD …
Pro-motility Preparation Protocol May Reduce the Rates of Failed Patency Capsule Among Patients with Crohn's Disease in Clinical Remission
Publication Year: 2024 Source: Dig Dis Sci PMID: 39384710
No Abstract
Ulcerative colitis: molecular insights and intervention therapy
Publication Year: 2024 Source: Mol Biomed PMID: 39384730
No Abstract
Investigating the causal relationship between inflammatory bowel disease and simple appendicitis using Mendelian randomization
Publication Year: 2024 Source: Sci Rep PMID: 39384932 DOI: 10.1038/s41598-024-74572-5
The relationship between simple appendicitis and inflammatory bowel disease (IBD) is not clear. In this study, we approach the issue from a genetic perspective, using Mendelian randomization (MR) tools to explore the potential causal connection between the two. We used GWAS data from 12,882 IBD patients (21,770 controls), 5956 crohn's …
Public deliberation to assess patient views on biosimilar medication switching for the treatment of inflammatory bowel disease
Publication Year: 2024 Source: BMC Health Serv Res PMID: 39385143 DOI: 10.1186/s12913-024-11570-3
BACKGROUND: Biosimilars are highly similar, but not identical, versions of originator biologic medications. Switching patients to biosimilars presents an opportunity to mitigate rising drug costs and expand patient access to important biologic therapies. However, decreased patient acceptance and adherence to biosimilar medications have been reported, which can lead to loss …
Mannose coated selenium nanoparticles normalize intestinal homeostasis in mice and mitigate colitis by inhibiting NF-κB activation and enhancing glutathione peroxidase expression
Publication Year: 2024 Source: J Nanobiotechnology PMID: 39385176 DOI: 10.1186/s12951-024-02861-2
Impaired intestinal homeostasis is a major pathological feature of inflammatory bowel diseases (IBD). Mannose and selenium (Se) both demonstrate potential anti-inflammatory and anti-oxidative properties. However, most lectin receptors bind free monosaccharide ligands with relatively low affinity and most Se species induce side effects beyond a very narrow range of dosage. …
Unwinding the Threads of Mesoporous Silica Nanoparticles as Cutting-Edge for the Management of Inflammation: An Updated Review
Publication Year: 2024 Source: Curr Pharm Biotechnol PMID: 39385422
No Abstract
The injectable hydrogel loading cannabidiol to regulate macrophage polarization in vitro for the treatment of chronic enteritis
Publication Year: 2024 Source: J Appl Biomater Funct Mater PMID: 39385453
No Abstract
Interrupting inflammatory bowel disease therapy: why, who, when and how to consider medication holidays
Publication Year: 2024 Source: Expert Rev Gastroenterol Hepatol PMID: 39385720 DOI: 10.1080/17474124.2024.2412048
INTRODUCTION: Medication holidays in inflammatory bowel disease (IBD) offer a potential means to balance disease management, costs, and quality of life. This concept is increasingly relevant in light of the chronic nature of IBD, the cumulative side effects associated with long-term pharmacotherapy, and the evolving treatment landscape that now includes …
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