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Treatment trajectories and outcomes in inflammatory bowel disease: a tertiary single-centre experience

Publication Year: 2024 Source: Therap Adv Gastroenterol PMID: 39381754 DOI: 10.1177/17562848241284051

BACKGROUND: There is an increasing diversification in the treatment landscape for inflammatory bowel diseases (IBD) leading to therapeutic challenges that can only incompletely be covered by prospective randomized double-blind trials. Real-world observations are therefore an important tool to provide insights into therapeutic strategies. OBJECTIVES: To describe the real-world treatment algorithms …

Effects of genetic and clinical factors on thiopurine drugs pharmacokinetics in Tunisian patients

Publication Year: 2024 Source: Pharmacogenomics PMID: 39382000

No Abstract

Comment on: Coinciding Crohn's disease and polyarteritis nodosa: A sign of medically refractory disease?

Publication Year: 2024 Source: Int J Rheum Dis PMID: 39382239

No Abstract

Incidence of intestinal & extra-intestinal cancers among individuals with Crohn's disease in northern India

Publication Year: 2024 Source: Indian J Med Res PMID: 39382506

No Abstract

Therapeutic drug monitoring in inflammatory bowel disease: recent developments

Publication Year: 2024 Source: Expert Rev Gastroenterol Hepatol PMID: 39382556 DOI: 10.1080/17474124.2024.2409300

INTRODUCTION: Therapeutic Drug Monitoring (TDM) has an important role in the management of inflammatory bowel disease (IBD) patients on infliximab (IFX) or adalimumab and is recommended in IBD patients presenting a loss of response under anti TNF agent. But, TDM was not recommended for others biotherapies. AREAS COVERED: Analyzing all …

Successful treatment of Crohn's disease-related peripheral spondyloarthritis with upadacitinib: two case reports and case-based review

Publication Year: 2024 Source: Rheumatol Int PMID: 39382686 DOI: 10.1007/s00296-024-05735-w

Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease (CD), not only causes significant intestinal inflammation but also leads to extra-intestinal manifestations such as spondyloarthritis (SpA). Although the efficacy of tumor necrosis factor (TNF) inhibitors has been reported for IBD-related SpA, some cases still encounter treatment failure, highlighting the …

Antibiotic Exposure and Risk of New-Onset Ulcerative Colitis: a Systematic Review and Meta-Analysis

Publication Year: 2024 Source: Clin Lab PMID: 39382910

No Abstract

Pharmacological treatment of postoperative recurrence of Crohn's disease: Protocol for systematic review and network meta-analysis

Publication Year: 2024 Source: PLoS One PMID: 39383157

No Abstract

Identification of novel indolinone derivatives as CTSC inhibitors to treat inflammatory bowel disease by modulating inflammatory factors

Publication Year: 2024 Source: Eur J Med Chem PMID: 39383651 DOI: 10.1016/j.ejmech.2024.116914

Novel inflammatory bowel disease (IBD) therapeutic drugs, mainly biologics that neutralize pro-inflammatory factors and janus kinase inhibitors that inhibit cytokine-mediated signal transduction, face problems including low efficacy rates, limited therapeutic benefits, and infection risks. It is an important task to find proteins that broadly regulate a variety of cytokines and …

Environmentally relevant level of PFDA exacerbates intestinal inflammation by activating the cGAS/STING/NF-κB signaling pathway

Publication Year: 2024 Source: Sci Total Environ PMID: 39383958 DOI: 10.1016/j.scitotenv.2024.176786

As a constituent of the Per- and Polyfluoroalkyl Substances (PFAS) family, perfluorodecanoic acid (PFDA) is ubiquitous in the environment and enters the human body through environmental exposure, the food chain, and other pathways, resulting in various toxic effects. Previous population-based studies have suggested a correlation between PFDA exposure and inflammation. …

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