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Cordycepin mitigates dextran sulfate sodium-induced colitis through improving gut microbiota composition and modulating Th1/Th2 and Th17/Treg balance
Publication Year: 2024 Source: Biomed Pharmacother PMID: 39395256 DOI: 10.1016/j.biopha.2024.117394
BACKGROUND: Imbalances in Th1/Th2 and Th17/Treg immune axes, coupled with disruptions in the gut microbiota (GM), play a pivotal role in the pathogenesis of inflammatory bowel disease (IBD). Cordycepin, a natural anti-inflammatory compound, holds promise in mitigating IBD by rebalancing these immune axes in conjunction with modulating the GM. The …
Sex and gender in inflammatory bowel disease outcomes and research
Publication Year: 2024 Source: Lancet Gastroenterol Hepatol PMID: 39395438 DOI: 10.1016/S2468-1253(24)00159-6
Extensive patient heterogeneity is a challenge in the management of inflammatory bowel disease (IBD). Sex and gender, as well as the interaction of sex and gender with other social identities, referred to as intersectionality, contribute to this heterogeneity and might affect IBD outcomes. An interdisciplinary team of clinicians, researchers, patients, …
No Impact of Concomitant Medications on Efficacy and Safety of Biologics and Small Molecules for Ulcerative Colitis
Publication Year: 2024 Source: Clin Gastroenterol Hepatol PMID: 39395572
No Abstract
Heartaches and Gut Feelings: Exploring Myocarditis in Crohn's Disease
Publication Year: 2024 Source: Dig Dis Sci PMID: 39395926 DOI: 10.1007/s10620-024-08674-5
No Abstract
The different impacts of pain-related negative emotion and trait negative emotion on brain function in patients with inflammatory bowel disease
Publication Year: 2024 Source: Sci Rep PMID: 39396081 DOI: 10.1038/s41598-024-75237-z
Inflammatory bowel diseases (IBD) are a group of chronic, non-specific intestinal diseases that could comorbid with varieties of negative emotional constructs, including pain-related negative emotions and trait negative emotions; however, the link between brain functions and different dimensions of negative emotions remains largely unknown. Ninety-eight patients with IBD and forty-six …
Pathologist-level diagnosis of ulcerative colitis inflammatory activity level using an automated histological grading method
Publication Year: 2024 Source: Int J Med Inform PMID: 39396418 DOI: 10.1016/j.ijmedinf.2024.105648
BACKGROUND AND AIMS: Inflammatory bowel disease (IBD) is a global disease that is evolving with increasing incidence. However, there are few works on computationally assisted diagnosis of IBD based on pathological images. Therefore, based on the UK and Chinese IBD diagnostic guidelines, our study established an artificial intelligence-assisted diagnostic system …
Knowledge, attitudes, and practices of endoscopy among gastroenterologists in diagnosis and management of inflammatory bowel disease in China: a multicenter cross-sectional study
Publication Year: 2024 Source: BMC Gastroenterol PMID: 39396953 DOI: 10.1186/s12876-024-03436-z
BACKGROUND: The aim was to assess the knowledge, attitudes, and practices (KAPs) of endoscopy among gastroenterologists in the diagnosis and management of IBD in China. METHODS: A multicenter cross-sectional KAP study was performed. The questionnaire was developed and improved using feedback and opinions from a team of experienced IBD specialist …
Association between visceral adiposity index and bowel habits and inflammatory bowel disease: a cross-sectional study
Publication Year: 2024 Source: Sci Rep PMID: 39397029 DOI: 10.1038/s41598-024-73864-0
Obesity has become a global public health problem, and its relationship with gastrointestinal diseases has become a major concern. The visceral adiposity index (VAI) is a novel index to assess the distribution and content of visceral fat, and this study aimed to investigate the association between VAI and bowel habits …
Quantification of deoxythioguanosine in human DNA with LC-MS/MS, a marker for thiopurine therapy optimisation
Publication Year: 2024 Source: Anal Bioanal Chem PMID: 39397163 DOI: 10.1007/s00216-024-05581-6
In the treatment of diseases such as acute childhood leukaemia (ALL) and inflammatory bowel disease (IBD), the thiopurines azathioprine, 6-mercaptopurine, and 6-thioguanine are used. Thiopurines are antimetabolites and immunomodulators used to maintain remission in patients. They are all prodrugs and must be converted into the competing antimetabolites thioguanosine triphosphate and …
ChiA: a major player in the virulence of Crohn's disease-associated adherent and invasive Escherichia coli (AIEC)
Publication Year: 2024 Source: Gut Microbes PMID: 39397494
No Abstract
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