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Silent Struggles Within: Alexithymia Unveiled in Irritable Bowel Syndrome: A Systematic Review and Meta-analysis
Publication Year: 2024 Source: J Neurogastroenterol Motil PMID: 39397617
No Abstract
Clostridium sporogenes-derived metabolites protect mice against colonic inflammation
Publication Year: 2024 Source: Gut Microbes PMID: 39397690 DOI: 10.1080/19490976.2024.2412669
Gut microbiota-derived metabolites play a pivotal role in the maintenance of intestinal immune homeostasis. Here, we demonstrate that the human commensal Clostridium sporogenes possesses a specific metabolic fingerprint, consisting predominantly of the tryptophan catabolite indole-3-propionic acid (IPA), the branched-chain acids (BCFAs) isobutyrate and isovalerate and the short-chain fatty acids (SCFAs) …
Pyoderma Gangrenosum in an Ulcerative Colitis Patient on Vedolizumab
Publication Year: 2024 Source: Cureus PMID: 39398841
No Abstract
Coumarin: A natural solution for alleviating inflammatory disorders
Publication Year: 2024 Source: Curr Res Pharmacol Drug Discov PMID: 39398983
No Abstract
Genetic disease risks of under-represented founder populations in New York City
Publication Year: 2024 Source: medRxiv PMID: 39399040 DOI: 10.1101/2024.09.27.24314513
The detection of founder pathogenic variants, those observed in high frequency only in a group of individuals with increased inter-relatedness, can help improve delivery of health care for that community. We identified 16 groups with shared ancestry, based on genomic segments that are shared through identity by descent (IBD), in …
The JAK inhibitor, Tofacitinib, Corrects the Overexpression of CEACAM6 and Limits Susceptibility to AIEC Caused by Reduced Activity of the IBD Associated Gene, PTPN2
Publication Year: 2024 Source: medRxiv PMID: 39399045 DOI: 10.1101/2024.09.26.24314341
BACKGROUND AND AIMS: A cohort of patients with inflammatory bowel disease (IBD) exhibit expansion of the gut pathobiont, adherent-invasive E. coli (AIEC). Loss of activity of the IBD susceptibility gene, protein tyrosine phosphatase type 2 (PTPN2), results in dysbiosis of the gut microbiota both in human subjects and mice. Further, …
Successful Treatment of Severe Pyoderma Gangrenosum and Ulcerative Colitis With Upadacitinib
Publication Year: 2024 Source: ACG Case Rep J PMID: 39399247
No Abstract
Histone acylations as a mechanism for regulation of intestinal epithelial cells
Publication Year: 2024 Source: Dig Med Res PMID: 39399394
Histone post-translational modifications are reversible epigenetic mechanisms that regulate chromatin structure and gene transcription. In recent years, in addition to the well-characterized histone acetylation, new acylations such as propionylation, crotonylation, butyrylation and beta-hydroxybutyrylation have been described and explored in different cell types at contexts of health and disease. Understanding how …
Crohn's disease presenting with pleural effusion: a case report
Publication Year: 2024 Source: Oxf Med Case Reports PMID: 39399794
No Abstract
Lactobacillus plantarum 69-2 combined with α-lactalbumin hydrolysate alleviates DSS-induced ulcerative colitis through the TLR4/NF-κB inflammatory pathway and the gut microbiota in mice
Publication Year: 2024 Source: Food Funct PMID: 39400032
No Abstract
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