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Clinical Trial Design Considerations for Hospitalised Patients With Ulcerative Colitis Flares and Application to Study Hyperbaric Oxygen Therapy in the NIDDK HBOT-UC Consortium
Publication Year: 2024 Source: Aliment Pharmacol Ther PMID: 39403018
No Abstract
Review article: Prevention of inflammatory bowel disease-The path forward
Publication Year: 2024 Source: Aliment Pharmacol Ther PMID: 39403049 DOI: 10.1111/apt.18263
BACKGROUND: The possibility of preventing inflammatory bowel disease (IBD) is becoming more plausible due to advances in understanding preclinical disease and successful prevention trials in other immune-mediated diseases, such as type 1 diabetes and rheumatoid arthritis. However, before that possibility becomes reality, several efforts need to occur in parallel and …
Review article: Novel therapies in inflammatory bowel disease - An update for clinicians
Publication Year: 2024 Source: Aliment Pharmacol Ther PMID: 39403052 DOI: 10.1111/apt.18294
BACKGROUND: Several new treatments including small molecules and biologics have been approved for the treatment of inflammatory bowel diseases in recent years. Clinicians and patients now have a wide variety of therapeutic options to choose from and these novel therapies provide several advantages including oral administration, lower immunogenicity, better selectivity …
Review article: Measuring disease severity in inflammatory bowel disease - Beyond treat to target
Publication Year: 2024 Source: Aliment Pharmacol Ther PMID: 39403053 DOI: 10.1111/apt.18231
BACKGROUND: Inflammatory bowel disease (IBD) follows a heterogenous disease course and predicting a patient's prognosis is challenging. There is a wide burden of illness in IBD and existing tools measure disease activity at a snapshot in time. Comprehensive assessment of IBD severity should incorporate disease activity, prognosis, and the impacts …
Review article: Optimisation of biologic (monoclonal antibody) therapeutic response in inflammatory bowel disease
Publication Year: 2024 Source: Aliment Pharmacol Ther PMID: 39403056 DOI: 10.1111/apt.18228
BACKGROUND: There are a plethora of therapeutic options for the management of inflammatory bowel disease (IBD). Despite this, clinical outcomes with standard dosing often fall short of established targets. While efforts centre on developing novel therapies, there is an ongoing need to optimise the use of existing agents. AIMS: To …
Inflammatory bowel disease in 2024 and beyond
Publication Year: 2024 Source: Aliment Pharmacol Ther PMID: 39403063
No Abstract
Ten-year outcomes of a prospective population-based incidence cohort of inflammatory bowel disease patients from Canterbury, New Zealand
Publication Year: 2024 Source: JGH Open PMID: 39403112 DOI: 10.1002/jgh3.70038
BACKGROUND AND AIM: Inflammatory bowel disease (IBD) is a progressive condition where ongoing inflammation in the gastrointestinal tract can lead to complications such as strictures, and fistulae. The long-term outcomes of newly diagnosed patients under current medical therapy can be used to plan health service provision and guide patients. METHODS: …
Traditional clinical symptoms and signs: Kampo pattern diagnosis in modern gastrointestinal disease
Publication Year: 2024 Source: Front Pharmacol PMID: 39403141 DOI: 10.3389/fphar.2024.1426491
INTRODUCTION: In traditional Japanese Kampo medicine, a profound anamnesis is completed by clinical examination. The resulting clinical image forms the basis of the patient's diagnosis pattern, including the recent mental, physical, and social contexts. Kampo questionnaires support pattern diagnosis and bridge traditional and Western medicine diagnoses. AIMS OF THE STUDY: …
Paradoxical psoriasiform dermatitis involving the nasal mucosa in the setting of infliximab for inflammatory bowel disease
Publication Year: 2024 Source: JAAD Case Rep PMID: 39403182 DOI: 10.1016/j.jdcr.2024.07.023
No Abstract
Evaluation of the Symptoms and Clinical Characteristics of Crohn's Disease and Ulcerative Colitis That Affect Healthcare Providers' Treatment Choices
Publication Year: 2024 Source: Crohns Colitis 360 PMID: 39403225 DOI: 10.1093/crocol/otae053
BACKGROUND: Treatment of inflammatory bowel disease-Crohn's disease (CD) and ulcerative colitis (UC)-is dependent on healthcare providers' (HCPs') clinical assessment of patient symptoms. We therefore evaluated which CD and UC symptoms impact HCPs' treatment choices and assessed the impact of those symptoms on treatment decision-making. We also examined the role of …
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