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Prescribed cumulative dosage of corticosteroids to patients with inflammatory bowel disease diagnosed between 2006 and 2020: a retrospective observational study

Publication Year: 2024 Source: Therap Adv Gastroenterol PMID: 39403301 DOI: 10.1177/17562848241288851

BACKGROUND: Treatments and strategies for inflammatory bowel disease (IBD) have gradually evolved in the 2000s. OBJECTIVES: We investigated whether the prescription of corticosteroids (prednisolone and budesonide) in patients with IBD in the first 5 years after diagnosis changed in patients diagnosed between 2006 and 2018. DESIGN: Retrospective observational study. METHODS: …

Refractory Crohn's Disease: Perspectives, Unmet Needs and Innovations

Publication Year: 2024 Source: Clin Exp Gastroenterol PMID: 39403342

No Abstract

The efficacy of curcumin/Qing Dai combination in children with active ulcerative colitis: a multicenter retrospective cohort study

Publication Year: 2024 Source: Front Pediatr PMID: 39403348 DOI: 10.3389/fped.2024.1342656

BACKGROUND: Curcumin and Qing Dai (QD) are herbal extracts that recently showed efficacy in treating inflammatory bowel disease (IBD). Since 2016, a combination of curcumin with QD (CurQD) has been employed in our center for management of active ulcerative colitis (UC). OBJECTIVES: We report the effectiveness and safety of CurQD …

NOD2-mediated dual negative regulation of inflammatory responses triggered by TLRs in the gastrointestinal tract

Publication Year: 2024 Source: Front Immunol PMID: 39403381

No Abstract

HLA-DRB1*01:03 and Severe Ulcerative Colitis

Publication Year: 2024 Source: JAMA PMID: 39403737

No Abstract

DeepPhylo: Phylogeny-Aware Microbial Embeddings Enhanced Predictive Accuracy in Human Microbiome Data Analysis

Publication Year: 2024 Source: Adv Sci (Weinh) PMID: 39403892 DOI: 10.1002/advs.202404277

Microbial data analysis poses significant challenges due to its high dimensionality, sparsity, and compositionality. Recent advances have shown that integrating abundance and phylogenetic information is an effective strategy for uncovering robust patterns and enhancing the predictive performance in microbiome studies. However, existing methods primarily focus on the hierarchical structure of …

Human breast milk-derived phospholipid DOPE ameliorates intestinal injury associated with NEC by inhibiting ferroptosis

Publication Year: 2024 Source: Food Funct PMID: 39403969

No Abstract

Incidence of rectal cancer after colectomy for inflammatory bowel disease: nationwide study

Publication Year: 2024 Source: BJS Open PMID: 39404038

No Abstract

The Modulatory Effects and Therapeutic Potential of Cannabidiol in the Gut

Publication Year: 2024 Source: Cells PMID: 39404382 DOI: 10.3390/cells13191618

Cannabidiol (CBD) is a major non-psychotropic phytocannabinoid that exists in the Cannabis sativa plant. CBD has been found to act on various receptors, including both cannabinoid and non-cannabinoid receptors. In addition, CBD has antioxidant effects that are independent of receptors. CBD has demonstrated modulatory effects at different organ systems, such …

Recognizing the biological barriers and pathophysiological characteristics of the gastrointestinal tract for the design and application of nanotherapeutics

Publication Year: 2024 Source: Drug Deliv PMID: 39404464

No Abstract

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