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Differential analysis of sorting nexin 10 and sterol regulatory element-binding protein 2 expression in inflammatory bowel disease
Publication Year: 2024 Source: Immunol Res PMID: 39412576 DOI: 10.1007/s12026-024-09539-9
Sorting nexin 10 (SNX10) expression induces intestinal barrier dysfunction and inflammatory responses; in contrast, its inhibition promotes intestinal mucosal healing through sterol regulatory element-binding protein 2 (SREBP2)-mediated cholesterol synthesis. However, its regulatory mechanism for the pathogenesis of inflammatory bowel disease (IBD) remains unclear. In this study, we examined SNX10 and …
Drug-induced acute febrile neutrophilic dermatosis (Sweet syndrome): A case report presented at Delhi State Cancer Institute
Publication Year: 2024 Source: J Cancer Res Ther PMID: 39412928
Sweet syndrome is a rare, etiologically unknown dermatosis that can be idiopathic or associated with certain clinical conditions. Among these conditions are infections, autoimmune diseases, inflammatory bowel diseases, vaccinations, the use of medications, and neoplasias. Hematological neoplasias, particularly acute myeloid leukemia, are the most commonly described; however, the condition may …
Effect of telomere shortening on disease progression in patients with inflammatory bowel disease: A systematic review and meta-analysis protocol
Publication Year: 2024 Source: PLoS One PMID: 39413125 DOI: 10.1371/journal.pone.0311662
INTRODUCTION: Inflammatory bowel disease (IBD) remains a major public health challenge worldwide. In recent years, it has been discovered that a link between telomere shortening and disease progression in IBD patients has been present. However, there is controversy as to whether telomere shortening precipitates disease progression or disease progression causes …
Pharmacological potential of natural medicine Astragali Radix in treating intestinal diseases
Publication Year: 2024 Source: Biomed Pharmacother PMID: 39413615 DOI: 10.1016/j.biopha.2024.117580
Due to changes in diet and lifestyle, the prevalence of intestinal diseases has been increasing annually. Current treatment methods exhibit several limitations, including adverse reactions and drug resistance, necessitating the development of new, safe, and effective therapies. Astragali Radix, a natural medicine utilized for over two millennia, offers unique advantages …
Agmatine attenuates the severity of immunometabolic disorders by suppressing macrophage polarization: an in vivo study using an ulcerative colitis mouse model
Publication Year: 2024 Source: Biomed Pharmacother PMID: 39413617
No Abstract
Unraveling the long-term gastrointestinal impact of perinatal perfluorobutane sulfonate exposure on rat offspring: Intestinal barrier dysfunction and Th17/Treg imbalance
Publication Year: 2024 Source: Sci Total Environ PMID: 39414058 DOI: 10.1016/j.scitotenv.2024.176858
Per- and polyfluoroalkyl substances (PFAS), especially long-chain perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS), are increasingly acknowledged as a potential inflammatory bowel diseases (IBD) risk factor. Perfluorobutane sulfonate (PFBS), one kind of shorter chain alternative, has been reported to exhibit similar health hazards to those long-chain PFAS. However, the underlying …
Cryptosporidiosis in individuals with inflammatory bowel disease: a scoping review protocol
Publication Year: 2024 Source: BMJ Open PMID: 39414295 DOI: 10.1136/bmjopen-2024-086529
INTRODUCTION: Cryptosporidiosis is a leading cause of moderate-to-severe diarrhoea globally, and, while it is often self-limited, in immunocompromised individuals, the infection can be associated with significant morbidity and mortality. Diagnosis might be missed or delayed in patients with inflammatory bowel disease (IBD) due to similar presentation, and these patients may …
A Self-led Self-management Intervention Supporting Teens with IBD (ASSIST-IBD): protocol for a feasibility study of a novel digital treatment adherence intervention
Publication Year: 2024 Source: BMJ Open PMID: 39414300 DOI: 10.1136/bmjopen-2024-085576
INTRODUCTION: Treatment non-adherence is common in young people with inflammatory bowel disease (IBD), yet support is lacking. A self-led self-management intervention supporting teens with IBD (ASSIST-IBD) is a new theory-based digital treatment adherence intervention, co-developed by young people living with IBD. ASSIST-IBD includes 10 short modules supporting adolescents to feel …
Identification of potential novel targets for treating inflammatory bowel disease using Mendelian randomization analysis
Publication Year: 2024 Source: Int J Colorectal Dis PMID: 39414629 DOI: 10.1007/s00384-024-04744-2
BACKGROUND: Inflammatory bowel disease (IBD) is a complex autoimmune disorder, although some medications are available for its treatment. However, the long-term efficacy of these drugs remains unsatisfactory. Therefore, there is a need to develop novel drug targets for IBD treatment. METHODS: We conducted two-sample Mendelian randomization (MR) analysis using Genome-Wide …
Associations of intestinal diseases with anal diseases: a Mendelian randomization study
Publication Year: 2024 Source: Sci Rep PMID: 39414900 DOI: 10.1038/s41598-024-75082-0
Although observational clinical studies have established an association between Intestinal Diseases (IDS) and Anal Diseases (ADS), the causal relationship is still not fully understood due to the limitations of observational studies. Genome-wide association study (GWAS) statistical data for IDS and ADS were obtained from publicly available databases. To assess the …
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