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Provider Education and Clinical Decision Support Tool Improve Proficiency in Advanced Therapies for Inflammatory Bowel Disease
Publication Year: 2024 Source: Inflamm Bowel Dis PMID: 39673214 DOI: 10.1093/ibd/izae270
BACKGROUND: Despite the growing availability of advanced medical therapies for inflammatory bowel disease (IBD), significant gaps remain in treatment initiation. Targeted education and point-of-care clinical decision support may address this gap and lead to improved patient outcomes. METHODS: A multiphase IBD-focused provider education and decision support program spanning 10 years …
Bioinformatics analysis reveals potential crosstalk genes and molecular mechanisms between ulcerative colitis and psoriasis
Publication Year: 2024 Source: Arch Dermatol Res PMID: 39673621
No Abstract
An untargeted metabolomic study using MALDI-mass spectrometry imaging reveals region-specific biomarkers associated with bowel inflammation
Publication Year: 2024 Source: Metabolomics PMID: 39674857
No Abstract
Comparative Efficacy and Safety of Endoscopic Modalities for Colorectal Cancer Screening in Inflammatory Bowel Disease: A Systematic Review and Network Meta-analysis
Publication Year: 2024 Source: Clin Gastroenterol Hepatol PMID: 39675405 DOI: 10.1016/j.cgh.2024.11.008
BACKGROUND & AIMS: Long-standing inflammatory bowel disease (IBD) increases the risk of colonic neoplasia, necessitating effective screening strategies. This network meta-analysis compared the efficacy and safety between different endoscopic modalities in the high-definition (HD) era. METHODS: We searched CENTRAL, ClinicalTrials.gov, Embase, MEDLINE, and WHO for randomized controlled trials (RCTs) comparing …
Prevalence and Prognosis of Mild Inflammatory Bowel Disease: A Population-based Cohort Study, 1997-2020
Publication Year: 2024 Source: Clin Gastroenterol Hepatol PMID: 39675406 DOI: 10.1016/j.cgh.2024.10.021
BACKGROUND & AIMS: The inflammatory bowel diseases (IBDs), ulcerative colitis (UC) and Crohn's disease (CD), are heterogenous diseases ranging from mild to severe. We aimed to describe the prevalence and prognosis of mild IBD in an unselected population-based patient cohort. METHODS: We identified all individuals diagnosed with IBD during 1997 …
The microbiota metabolite, phloroglucinol, confers long-term protection against inflammation
Publication Year: 2024 Source: Gut Microbes PMID: 39676480
No Abstract
Beyond Bone Grafts: Exploring the Efficacy of Alternative Regenerative Therapies
Publication Year: 2024 Source: Cureus PMID: 39677141 DOI: 10.7759/cureus.73745
Context A vast body of published literature examines and evaluates the properties of bone restorative materials in combination with other biomaterials or as stand-alone applications. If we exclude the studies investigating the effectiveness of regenerative therapy with enamel matrix derivative (EMD), in all other cases, bone regenerative materials are placed …
Suboptimal Vaccination Coverage and Serological Screening in Western Australian Children With Inflammatory Bowel Disease Receiving Immunosuppressive Therapy: An Opportunity for Improvement
Publication Year: 2024 Source: Cureus PMID: 39677205 DOI: 10.7759/cureus.73744
Background Patients with inflammatory bowel disease (IBD) face an increased likelihood of severe illnesses, including those caused by vaccine-preventable diseases. Consequently, the purpose of this study was to evaluate both vaccination rates and serological screening in children with IBD in Western Australia, focusing on compliance with routine and additional vaccines, …
Estrogen Receptor β Alleviates Colitis by Inhibiting Ferroptosis in Intestinal Epithelial Cells
Publication Year: 2024 Source: J Inflamm Res PMID: 39677282
No Abstract
Inflammatory Bowel Disease Drivers Revealed in Human Organ Chips
Publication Year: 2024 Source: medRxiv PMID: 39677416 DOI: 10.1101/2024.12.05.24318563
Inflammatory bowel disease (IBD) patients exhibit compromised intestinal barrier function and decreased mucus accumulation, as well as increased inflammation, fibrosis, and cancer risk, with symptoms often being exacerbated in women during pregnancy. Here, we show that these IBD hallmarks can be replicated using human Organ Chips lined by IBD patient-derived …
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