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Integrating single-cell RNA-Seq and machine learning to dissect tryptophan metabolism in ulcerative colitis
Publication Year: 2024 Source: J Transl Med PMID: 39707393 DOI: 10.1186/s12967-024-05934-w
BACKGROUND: Ulcerative colitis (UC) is a persistent inflammatory bowels disease (IBD) characterized by immune response dysregulation and metabolic disruptions. Tryptophan metabolism has been believed as a significant factor in UC pathogenesis, with specific metabolites influencing immune modulation and gut microbiota interactions. However, the precise regulatory mechanisms and key genes involved …
Resistant starch grafted cerium-sulfasalazine infinite coordination polymers synergistically remold intestinal metabolic microenvironment for inflammatory bowel disease therapy
Publication Year: 2024 Source: J Nanobiotechnology PMID: 39707422 DOI: 10.1186/s12951-024-03043-w
Inflammatory bowel disease (IBD) is a chronic gastrointestinal disease which is closely related with the overproduced reactive oxygen species (ROS), increased pro-inflammatory cytokines and disordered intestinal microbes. However, current therapeutic methods usually ignored the interrelation among the pathogenesis, and mainly focused on a single factor, inducing clinical outcomes unsatisfied. Herein, …
Modulation of Inflammation Levels and the Gut Microbiota in Mice with DSS-Induced Colitis by a Balanced Vegetable Protein Diet
Publication Year: 2024 Source: Plant Foods Hum Nutr PMID: 39708200 DOI: 10.1007/s11130-024-01272-w
Inflammatory bowel disease (IBD) is a nonspecific chronic inflammatory disease of the intestine that is mainly divided into ulcerative colitis and Crohn's disease. Nutrients play important roles in the treatment of IBD. In this study, the effects of vegetable proteins on the regulation of IBD were explored via the amino …
Incidence of Hepatobiliary Malignancies in Primary Sclerosing Cholangitis: Systematic Review and Meta-analysis
Publication Year: 2024 Source: Clin Gastroenterol Hepatol PMID: 39709139 DOI: 10.1016/j.cgh.2024.09.037
BACKGROUND & AIMS: Primary sclerosing cholangitis (PSC) is a known risk factor for hepatobiliary malignancies. We conducted a systematic review and meta-analysis of published studies to determine the incidence and risk factors for hepatobiliary malignancies in people with PSC. METHODS: Pubmed and Embase databases were searched from inception to April …
Medium- to long-term outcomes of seton placement for fistula-in-ano in children: the experience of 103 patients from a single institution
Publication Year: 2024 Source: Pediatr Surg Int PMID: 39709324
No Abstract
Upadacitinib induction is effective and safe in ulcerative colitis patients including those with prior exposure to tofacitinib: a multicenter real-world cohort study
Publication Year: 2024 Source: Intest Res PMID: 39709985
No Abstract
Clinical decision support tool-guided, selective intensive induction strategy of ustekinumab in patients with Crohn's disease: A multicenter cohort study
Publication Year: 2024 Source: J Dig Dis PMID: 39710431
No Abstract
Angiogenesis, a key point in the association of gut microbiota and its metabolites with disease
Publication Year: 2024 Source: Eur J Med Res PMID: 39710789
No Abstract
Current Approaches to Ulcerative Colitis Management: A Comprehensive Overview of Methodologies and Treatments
Publication Year: 2024 Source: Infect Disord Drug Targets PMID: 39710926
No Abstract
Processed Dietary Fiber Partially Hydrolyzed Guar Gum Increases Susceptibility to Colitis and Colon Tumorigenesis in Mice
Publication Year: 2024 Source: Res Sq PMID: 39711544
No Abstract
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