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Cell-type-resolved chromatin accessibility in the human intestine identifies complex regulatory programs and clarifies genetic associations in Crohn's disease
Publication Year: 2024 Source: medRxiv PMID: 39711713
No Abstract
Clostridium butyricum, a future star in sepsis treatment
Publication Year: 2024 Source: Front Cell Infect Microbiol PMID: 39711782 DOI: 10.3389/fcimb.2024.1484371
Sepsis is a systemic inflammatory response syndrome of multiorgan failure caused by dysregulation of the host response to infection and is a major cause of death in critically ill patients. In recent years, with the continuous development of sequencing technology, the intestinal microecology of this disease has been increasingly studied. …
Advancing therapeutic frontiers: a pipeline of novel drugs for luminal and perianal Crohn's disease management
Publication Year: 2024 Source: Therap Adv Gastroenterol PMID: 39711916 DOI: 10.1177/17562848241303651
Crohn's disease (CD) is a chronic, complex inflammatory disorder of the gastrointestinal tract that presents significant therapeutic challenges. Despite the availability of a wide range of treatments, many patients experience primary non-response, secondary loss of response, or adverse events, limiting the overall effectiveness of current therapies. Clinical trials often report …
Common diagnostic biomarkers and molecular mechanisms of Helicobacter pylori infection and inflammatory bowel disease
Publication Year: 2024 Source: Front Immunol PMID: 39712025 DOI: 10.3389/fimmu.2024.1492810
BACKGROUND: Helicobacter pylori (H. pylori) may be present in the intestinal mucosa of patients with inflammatory bowel disease (IBD), which is a chronic inflammation of the gastrointestinal tract. The role of H. pylori in the pathogenesis of IBD remains unclear. In this study, bioinformatics techniques were used to investigate the …
Bolstering connectedness through peer support: Randomized-controlled trial of a web-based peer support program for adolescents with inflammatory bowel disease
Publication Year: 2024 Source: Health Care Transit PMID: 39712477 DOI: 10.1016/j.hctj.2024.100085
BACKGROUND: Inflammatory bowel disease (IBD) is a chronic autoimmune disease often diagnosed during adolescence. IBD negatively impacts all aspects of health-related quality of life, resulting in physical, emotional, social, school, and work functioning challenges. Adolescents have identified the need for peer support in managing their disease and promoting positive health …
Initial Experience With Safety and Efficacy of Endoscopic Full-Thickness Resection in Patients With Inflammatory Bowel Disease: A Case Series
Publication Year: 2024 Source: ACG Case Rep J PMID: 39712482 DOI: 10.14309/crj.0000000000001571
Endoscopic full-thickness resection (EFTR) is a novel endoscopic technique for removing complex colorectal lesions. The inflammatory bowel disease (IBD) population poses unique challenges for endoscopic resection due to an increased prevalence of fibrotic, nonlifting lesions and higher recurrence rates compared with the general population. This case series reports on the …
Living with an ostomy: A needs assessment in pediatric inflammatory bowel disease
Publication Year: 2024 Source: Health Care Transit PMID: 39712580 DOI: 10.1016/j.hctj.2024.100069
BACKGROUND: Inflammatory bowel disease (IBD) is a chronic, immune-mediated inflammatory condition of the digestive tract associated with substantial psychosocial difficulties. Treatment often focuses on medications but may also include surgical approaches (e.g., intestinal ostomy). Unfortunately, literature regarding the psychosocial implications of ostomy surgeries is scarce, and even less is known …
Caring for young adult men with inflammatory bowel disease: Clinician and patient perspectives
Publication Year: 2024 Source: Health Care Transit PMID: 39712589 DOI: 10.1016/j.hctj.2024.100043
Inflammatory bowel disease (IBD) presents unique challenges for young adult men that extend beyond physical symptoms, encompassing psychosocial dimensions affecting all aspects of life. This article draws insights from a roundtable discussion facilitated by the Crohn's and Colitis Young Adults Network (CCYAN), focusing on the experiences of young men living …
Medical trauma in young adults with inflammatory bowel disease: The role of trauma-informed care
Publication Year: 2024 Source: Health Care Transit PMID: 39712621 DOI: 10.1016/j.hctj.2024.100044
Medical trauma is a profound concern for those with chronic conditions like inflammatory bowel disease (IBD), especially young adults. This trauma, arising from both the disease itself and necessary medical interventions, manifests as an accumulation of traumatic experiences impacting a patient's physical and psychological well-being. The Crohn's and Colitis Young …
Perspectives on the extracellular matrix in inflammatory bowel disease and bowel decellularization protocols
Publication Year: 2024 Source: World J Exp Med PMID: 39713079 DOI: 10.5493/wjem.v14.i4.97179
No Abstract
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