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Identification of O-glycosylation related genes and subtypes in ulcerative colitis based on machine learning
Publication Year: 2024 Source: PLoS One PMID: 39739658
No Abstract
Superior persistence of ustekinumab compared to anti-TNF in vedolizumab-experienced inflammatory bowel diseases patients: a real-world cohort study
Publication Year: 2024 Source: BMC Gastroenterol PMID: 39741232 DOI: 10.1186/s12876-024-03577-1
BACKGROUND/AIMS: The increasing use of biologic therapies for moderate to severe inflammatory bowel disease (IBD) highlights the importance of optimal treatment sequencing, particularly after vedolizumab (VDZ) exposure. Studies comparing the effectiveness of ustekinumab (UST) and antitumor necrosis factor (anti-TNF) agents post-VDZ are limited. METHODS: This retrospective study analyzed VDZ-experienced IBD …
Impact of Fatigue on Work Productivity, Activity Impairment, and Healthcare Resource Utilization in Inflammatory Bowel Disease
Publication Year: 2024 Source: Crohns Colitis 360 PMID: 39742035 DOI: 10.1093/crocol/otae073
OBJECTIVES: Fatigue is commonly reported in patients with Crohn's disease (CD) and ulcerative colitis (UC), including patients with inactive disease. We explored the impact of fatigue on healthcare utilization (HCU) and work productivity and activity impairment (WPAI). METHODS: Data collected between 2017 and 2022 were analyzed from the CorEvitas IBD …
Houttuynia cordata-Derived Exosome-Like Nanoparticles Mitigate Colitis in Mice via Inhibition of the NLRP3 Signaling Pathway and Modulation of the Gut Microbiota
Publication Year: 2024 Source: Int J Nanomedicine PMID: 39742094
No Abstract
Effects of Vitamin D Supplementation on Serum 25-Hydroxy Cholecalciferol in Inflammatory Bowel Diseases: A Meta-Analysis of Randomized Clinical Trials
Publication Year: 2024 Source: Int J Prev Med PMID: 39742127 DOI: 10.4103/ijpvm.ijpvm_133_23
BACKGROUND: Earlier studies about the influence of vitamin D (Vit D) supplementation on patients with inflammatory bowel disease (IBD) reported inconsistent results. Current comprehensive systematic review and meta-analysis was conducted to assess the effect of Vit D supplementation on clinical and subclinical factors in patients with IBD. METHODS: PubMed, Scopus, …
Anti-inflammatory mechanism of Houttuynia cordata polysaccharides against ulcerative colitis based on multi-omics conjoint analysis
Publication Year: 2024 Source: Int J Biol Macromol PMID: 39521219
No Abstract
Perspectives on the sustained engagement with digital health tools: protocol for a qualitative interview study among people living with Inflammatory Bowel Disease or irritable bowel syndrome
Publication Year: 2024 Source: BMJ Open PMID: 39521469 DOI: 10.1136/bmjopen-2024-089220
INTRODUCTION: Digital health tools can be beneficial in the care of patients with chronic conditions and have the potential for widespread impact as readily scalable and cost-effective health interventions. However, benefits are often contingent on users sustaining their engagement with these tools over time. Sustained engagement with digital health tools …
The landscape of new therapeutic opportunities for IBD
Publication Year: 2024 Source: Adv Pharmacol PMID: 39521596 DOI: 10.1016/bs.apha.2024.10.011
This chapter presents an overview of the emerging strategies to address the unmet needs in the management of inflammatory bowel diseases (IBD). IBD poses significant challenges, as over half of patients experience disease progression despite interventions, leading to irreversible complications, and a substantial proportion do not respond to existing therapies, …
Emerging therapeutics for the management of intestinal fibrosis and strictures
Publication Year: 2024 Source: Adv Pharmacol PMID: 39521597 DOI: 10.1016/bs.apha.2024.09.001
Chronic intestinal inflammation in patients with inflammatory bowel disease (IBD) can lead to the development of fibrosis and the formation of strictures. Endoscopic balloon dilation and surgical resection are currently the only available treatments for fibrotic strictures. However, both strategies are associated with potential complications and high rates of stricture …
AXL: A novel therapeutic target in IBD
Publication Year: 2024 Source: Adv Pharmacol PMID: 39521598 DOI: 10.1016/bs.apha.2024.10.009
Inflammatory bowel diseases (IBD) and their sequela (colitis-associate carcinoma and fibrostenotic complications) remain a significant clinical challenge and novel therapeutic targets are desperately needed. AXL, a receptor tyrosine kinase, has been implicated in myriad cellular functions central to the pathogenesis of IBD. These include facilitating epithelial-to-mesenchymal transition, dampening of Toll-like …
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