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Current and emerging therapeutic strategies for perianal fistula in Crohn's disease patients
Publication Year: 2024 Source: Adv Pharmacol PMID: 39521599
No Abstract
The discovery and development of the sphingosine 1-phosphate receptor modulator ozanimod in ulcerative colitis
Publication Year: 2024 Source: Adv Pharmacol PMID: 39521600
No Abstract
BRD4 as an emerging epigenetic therapeutic target for inflammatory bowel disease
Publication Year: 2024 Source: Adv Pharmacol PMID: 39521601 DOI: 10.1016/bs.apha.2024.10.008
Inflammatory bowel disease (IBD) is a chronic gastrointestinal disorder, mainly comprising two subtypes: ulcerative colitis (UC) and Crohn's disease (CD). IBD, featured by recurrent symptoms and significant morbidity, poses a significant threat to global health and has an adverse impact on quality of life. Currently, there is no curative therapy …
Dectin-1 as a therapeutic target for inflammatory bowel disease
Publication Year: 2024 Source: Adv Pharmacol PMID: 39521602 DOI: 10.1016/bs.apha.2024.10.002
Inflammatory bowel disease (IBD) encompasses chronic inflammatory conditions of the distal gastrointestinal tract, including Crohn's disease and ulcerative colitis. This chapter explores the potential of Dendritic cell-associated C-type lectin-1 (Dectin-1), a pattern recognition receptor, as a therapeutic target for IBD. We delve into the multifaceted roles of Dectin-1 in immune …
Targeting glutamate carboxypeptidase II in IBD
Publication Year: 2024 Source: Adv Pharmacol PMID: 39521603 DOI: 10.1016/bs.apha.2024.10.001
Over the past decade, the zinc metalloenzyme glutamate carboxypeptidase (GCPII) has emerged as a novel therapeutic target for IBD. This enzyme is minimally expressed in healthy ileum or colon, but is profoundly upregulated in multiple IBD subtypes including: adult and pediatric Crohn's disease (CD), adult and pediatric ulcerative colitis (UC), …
TL1A: A model for a precision medicine approach in the treatment of Crohn's disease and ulcerative colitis
Publication Year: 2024 Source: Adv Pharmacol PMID: 39521604 DOI: 10.1016/bs.apha.2024.10.014
Inflammatory bowel disease (IBD) is a collective term for chronic inflammatory diseases of the intestinal tract. The term IBD encompasses two main forms, Crohn's disease (CD) and Ulcerative colitis (UC). CD is characterized by inflammation throughout the length of the gut, especially the ileum and colon, and is often complicated …
The potential of targeting TREM-1 in IBD
Publication Year: 2024 Source: Adv Pharmacol PMID: 39521605 DOI: 10.1016/bs.apha.2024.10.010
Innate immune dysfunction is a hallmark of the pathogenesis of Inflammatory Bowel Disease, both in Crohn's disease and ulcerative colitis. Despite considerable efforts in research to better understand the pathophysiology of IBD and for the development of new therapeutic modalities for IBD patients, there is no therapy specifically targeting the …
Anti-fibrotics in inflammatory bowel diseases: Challenges and successes
Publication Year: 2024 Source: Adv Pharmacol PMID: 39521606 DOI: 10.1016/bs.apha.2024.10.012
Stricture formation leading to obstruction in Crohn's disease (CD) remains one of the largest unmet needs in the field of inflammatory bowel diseases (IBD). Despite this need no selective anti-stricture drug has been approved for use in CD patients. This contrasts with other fibrotic diseases, such as in the lung, …
Mesenchymal stem cells: a novel therapeutic approach for feline inflammatory bowel disease
Publication Year: 2024 Source: Stem Cell Res Ther PMID: 39522034 DOI: 10.1186/s13287-024-04038-y
BACKGROUND: Inflammatory bowel disease (IBD) poses a significant and growing global health challenge, affecting both humans and domestic cats. Research on feline IBD has not kept pace with its widespread prevalence in human populations. This study aimed to develop a model of feline IBD by incorporating dextran sulfate sodium (DSS) …
Architectural crypt distortions in ulcerative colitis: Time for reappraisal
Publication Year: 2024 Source: J Gastroenterol Hepatol PMID: 39522510
No Abstract
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