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Inflammation-targeted delivery of Urolithin A mitigates chemical- and immune checkpoint inhibitor-induced colitis
Publication Year: 2024 Source: J Nanobiotechnology PMID: 39533380 DOI: 10.1186/s12951-024-02990-8
Inflammatory bowel disease (IBD) treatment often involves systemic administration of anti-inflammatory drugs or biologics such as anti-TNF-alpha antibodies. However, current drug therapies suffer from limited efficacy due to unresponsiveness and adverse side effects. To address these challenges, we developed inflammation-targeting nanoparticles (ITNPs) using biopolymers derived from the gum kondagogu (Cochlospermum …
Prevalence of comorbid autoimmune diseases and antibodies in newly diagnosed multiple sclerosis patients
Publication Year: 2024 Source: Neurol Res Pract PMID: 39533435
No Abstract
Dual-Locked Chemiluminescent Probe Enables Precise Imaging and Timely Diagnosis of Colitis via Chymotrypsin/Vanin-1 Cascade Activation
Publication Year: 2024 Source: Anal Chem PMID: 39533874 DOI: 10.1021/acs.analchem.4c02545
The development of precise diagnosis and the discovery of individualized drugs go together to provide effective therapy against inflammatory bowel disease (IBD). The exploitation of the unique imaging advantages of chemiluminescent probes represents a pivotal strategy for achieving this goal. Nevertheless, the dual-locked strategy, which is believed to enhance precision, …
Fusobacterium Nucleatum Aggravates Intestinal Barrier Impairment and Colitis Through IL-8 Induced Neutrophil Chemotaxis by Activating Epithelial Cells
Publication Year: 2024 Source: J Inflamm Res PMID: 39534061 DOI: 10.2147/JIR.S470376
BACKGROUND: Inflammatory bowel disease (IBD) is affected by interactions between intestinal microbial factors, abnormal inflammation, and an impaired intestinal mucosal barrier. Neutrophils (NE) are key players in IBD. Fusobacterium nucleatum (F. nucleatum) is reported to contribute to IBD progression. However, the relationship between F. nucleatum, abnormal inflammation, and intestinal barrier …
Dye-based chromoendoscopy detects more neoplasia than white light endoscopy in patients with primary sclerosing cholangitis and IBD
Publication Year: 2024 Source: Endosc Int Open PMID: 39534278 DOI: 10.1055/a-2437-8102
Background and study aims Patients with primary sclerosing cholangitis and inflammatory bowel disease (IBD) have a high risk of colorectal cancer. There is no agreement on the best technique for surveillance for colorectal neoplasia. We aimed to assess whether chromoendoscopy and/or high-definition endoscopy is associated with increased detection of neoplasia …
Addressing diagnostic delays in inflammatory bowel diseases in Germany
Publication Year: 2024 Source: World J Gastroenterol PMID: 39534412 DOI: 10.3748/wjg.v30.i41.4484
Inflammatory bowel diseases (IBDs), including Crohn's disease (CD) and ulcerative colitis, are chronic inflammatory conditions of the gastrointestinal tract that necessitate timely diagnosis to prevent complications and improve patient outcomes. Despite advancements in medical knowledge and diagnostic techniques, significant diagnostic delays persist, particularly in CD. The study by Bluthner et …
Navigating new horizons in inflammatory bowel disease: Integrative approaches and innovations
Publication Year: 2024 Source: World J Gastroenterol PMID: 39534414 DOI: 10.3748/wjg.v30.i41.4411
This editorial offers an updated synthesis of the major advancements in the management and treatment of inflammatory bowel disease (IBD), as documented in the World Journal of Gastroenterology between 2023 and early 2024. This editorial explores substantial developments across key research areas, such as intestinal microecology, computational drug discovery, dual …
Contribution of gut microbiota to the development of Crohn's disease: Insights gained from fecal microbiota transplantation studies in mice
Publication Year: 2024 Source: World J Gastroenterol PMID: 39534419
No Abstract
Protective effects of long term antiplatelet and anticoagulant therapy in hospitalized patients with inflammatory bowel disease
Publication Year: 2024 Source: World J Gastrointest Pharmacol Ther PMID: 39534521 DOI: 10.4292/wjgpt.v15.i6.95532
BACKGROUND: Inflammatory bowel disease (IBD), with its rising prevalence rates is associated with an increased risk of cardiovascular and thromboembolic events. Antiplatelets and/or anticoagulants agents are often prescribed but the literature on the impact of long-term anticoagulation and/or antiplatelet use among patients hospitalized with IBD is scarce. The aim of …
Inflammatory bowel disease in Pakistan: Low prevalence or underdiagnosis?
Publication Year: 2024 Source: World J Gastrointest Pharmacol Ther PMID: 39534522 DOI: 10.4292/wjgpt.v15.i6.99226
Inflammatory bowel disease (IBD) has a low prevalence in the Global South, including Pakistan. While genetics and gut flora, influenced by diet and the environment, can contribute to this, we are exploring the possibility of underdiagnosis. Lack of facilities trained in IBD, scarcity of medications, limited health insurance for specialist …
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