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Exposure to air pollution increases susceptibility to ulcerative colitis through epigenetic alterations in CXCR2 and MHC class III region
Publication Year: 2024 Source: EBioMedicine PMID: 39536393 DOI: 10.1016/j.ebiom.2024.105443
BACKGROUND: This study aims to confirm the associations of air pollution with ulcerative colitis (UC) and Crohn's disease (CD); to explore interactions with genetics and lifestyle; and to characterize potential epigenetic mechanisms. METHODS: We identified over 450,000 individuals from the UK Biobank and investigated the relationship between air pollution and …
Development of a deep learning algorithm for Paneth cell density quantification for inflammatory bowel disease
Publication Year: 2024 Source: EBioMedicine PMID: 39536395 DOI: 10.1016/j.ebiom.2024.105440
BACKGROUND: Alterations in ileal Paneth cell (PC) density have been described in gut inflammatory diseases such as Crohn's disease (CD) and could be used as a biomarker for disease prognosis. However, quantifying PCs is time-intensive, a barrier for clinical workflow. Deep learning (DL) has transformed the development of robust and …
Mesalamine loaded ethyl cellulose nanoparticles: optimization andin vivoevaluation of antioxidant potential in ulcerative colitis
Publication Year: 2024 Source: Biomed Mater PMID: 39536445
No Abstract
Metabolomics for enhanced clinical understanding of inflammatory bowel disease
Publication Year: 2024 Source: Life Sci PMID: 39537099 DOI: 10.1016/j.lfs.2024.123238
Metabolomics is an emerging field involving the systematic identification and quantification of numerous metabolites in biological samples. Precision medicine applies multiomics systems biology to individual patients for reliable diagnostic classification, disease monitoring, and treatment. Multiomics systems biology encompasses genomics, transcriptomics, proteomics, epigenomics, and metabolomics. Therefore, metabolomic techniques could be highly …
[Analysis of clinical characteristics and risk factors for recurrence of combined EB virus infection in patients with inflammatory bowel disease treated with biological agents]
Publication Year: 2024 Source: Zhonghua Yu Fang Yi Xue Za Zhi PMID: 39537410 DOI: 10.3760/cma.j.cn112150-20240620-00486
To investigate the degrees of EB virus reactivation in patients with inflammatory bowel disease (IBD) treated with different biologics and the levels of important cytokines associated with relapse under the influence of this virus, and to assess its diagnostic efficacy as a risk factor for identifying disease relapse. A case-control …
Chronic Abdominal Pain in Patients with Inflammatory Bowel Disease in Remission: A Continuing Challenge for Clinicians
Publication Year: 2024 Source: Dig Dis Sci PMID: 39537891 DOI: 10.1007/s10620-024-08716-y
Inflammatory bowel disease (IBD) is a chronic condition that includes ulcerative colitis and Crohn's disease. It is characterized by a relapsing and remitting pattern that negatively impacts quality of life (QoL). Current goals of treatment involve symptomatic, biochemical, and endoscopic remission in a treat-to-target approach. Despite effective treatment and remission …
Favorable inhibitory effect of clodronate on hepatic steatosis in short bowel syndrome model rats
Publication Year: 2024 Source: Pediatr Surg Int PMID: 39537943
No Abstract
Navigating SARS-CoV-2-related immunopathology in Crohn's disease: from molecular mechanisms to therapeutic challenges
Publication Year: 2024 Source: Virol J PMID: 39538233
No Abstract
[Evaluation of the usability of patients attended in gastrointestinal telemedicine postpandemic at University clinic]
Publication Year: 2024 Source: Rev Gastroenterol Peru PMID: 39538395
No Abstract
Matched Unrelated Donor Hematopoietic Stem Cell Transplant as Successful Curative Therapy for IL10RB Mutation-Associated Very Early Onset IBD
Publication Year: 2024 Source: Pediatr Transplant PMID: 39539152 DOI: 10.1111/petr.14891
BACKGROUND: Inflammatory bowel diseases are complex chronic disorders with a relapsing-remitting course that affect the gut due to dysregulated immune response. The incidence of these disorders is increasing globally along with an increase in the incidence in pediatric population. Very early onset inflammatory bowel diseases are seen in children with …
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