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Predictors for colectomy in patients with acute severe ulcerative colitis: a systematic review and meta-analysis
Publication Year: 2024 Source: BMJ Open Gastroenterol PMID: 39542522 DOI: 10.1136/bmjgast-2024-001587
OBJECTIVES: Acute severe ulcerative colitis (ASUC) poses challenges to patient management owing to its high surgical rate. This study aimed to identify predictors of colectomy in patients with ASUC. DESIGN: This is a systematic review and meta-analysis. DATA SOURCES: PubMed and Web of Science were searched up to April 2024. …
Systematic review of immune checkpoint inhibitor-related gastrointestinal, hepatobiliary, and pancreatic adverse events
Publication Year: 2024 Source: J Immunother Cancer PMID: 39542654
No Abstract
Comparing Environmental Risk Factors at Diagnosis in Faroese and Danish Patients with Inflammatory Bowel Disease
Publication Year: 2024 Source: Dig Dis Sci PMID: 39543023 DOI: 10.1007/s10620-024-08721-1
BACKGROUND: The incidence and prevalence of inflammatory bowel disease (IBD) in the Faroe Islands have increased drastically during the past 60 years, presumably due to changing environmental risk factors in a genetically susceptible population. AIM: This study investigated differing environmental factors present in Faroese and Danish patients. METHODS: From 2010 …
Induction of intercrypt goblet cells upon bacterial infection: a promising therapeutic target to restore the mucosal barrier
Publication Year: 2024 Source: Gut Microbes PMID: 39543081
No Abstract
Platelet activation through CD62P and the formation of platelet-monocyte complexes are associated with the exacerbation of mucosal inflammation in patients with ulcerative colitis
Publication Year: 2024 Source: Sci Rep PMID: 39543171
No Abstract
Extracts ofHylotelephiumerythrostictum (miq.) H. Ohba ameliorate intestinal injury by scavenging ROS and inhibiting multiple signaling pathways in Drosophila
Publication Year: 2024 Source: BMC Complement Med Ther PMID: 39543569 DOI: 10.1186/s12906-024-04686-w
BACKGROUND: The intestinal epithelial barrier is the first line of defense against pathogens and noxious substances entering the body from the outside world. Through proliferation and differentiation, intestinal stem cells play vital roles in tissue regeneration, repair, and the maintenance of intestinal homeostasis. Inflammatory bowel disease (IBD) is caused by …
Endoscopic endpoints in biologic clinical trials and beyond: the case for Crohn's Disease
Publication Year: 2024 Source: Expert Opin Biol Ther PMID: 39543952
No Abstract
Evidence linking gut-brain axis and Crohn's disease, focusing on neurotrophic dysfunctions and radiological imaging analysis - a systematic review
Publication Year: 2024 Source: Am J Transl Res PMID: 39544780
No Abstract
Sexual Dimorphism in the Immunometabolic Role of Gpr183 in Mice
Publication Year: 2024 Source: J Endocr Soc PMID: 39545055
No Abstract
Dietary Lactobacillus johnsonii-derived extracellular vesicles ameliorate acute colitis by regulating gut microbiota and maintaining intestinal barrier homeostasis
Publication Year: 2024 Source: Food Funct PMID: 39545264 DOI: 10.1039/d4fo04194a
Inflammatory bowel disease (IBD) is a chronic gastrointestinal disease with intricate pathogenesis, and clinical treatment is still not ideal. The imbalance of gut microbiota is associated with IBD progression. Various probiotics have been used as functional foods for the prevention and treatment of IBD, but the specific mechanism is still …
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