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Ganjiang Huangqin Huanglian Renshen Decoction protects against ulcerative colitis by modulating inflammation, oxidative stress, and gut microbiota
Publication Year: 2024 Source: Phytomedicine PMID: 39471735
No Abstract
Gut microbial and human genetic signatures of inflammatory bowel disease increase risk of comorbid mental disorders
Publication Year: 2024 Source: NPJ Genom Med PMID: 39472439 DOI: 10.1038/s41525-024-00440-w
The high prevalence of comorbid mental disorders (CMDs) in patients with inflammatory bowel disease (IBD) is well-documented. This study delves into the intricate CMD-IBD relationship through comprehensive analyses using human variants, gut microbiome, and anxiety/depression estimates from a cohort of 507 IBD patients and 75 controls. Notably, patients with IBD, …
Adherence to infliximab treatment in patients with immune-mediated inflammatory diseases from a referral center in Brazil: a cohort study
Publication Year: 2024 Source: BMC Gastroenterol PMID: 39472788
No Abstract
Genetic overlap between inflammatory bowel disease and iridocyclitis: insights from a genome-wide association study in a European population
Publication Year: 2024 Source: BMC Genom Data PMID: 39472800 DOI: 10.1186/s12863-024-01274-2
BACKGROUND: Inflammatory bowel disease (IBD) is occasionally associated with ophthalmic diseases, including iridocyclitis (IC). The co-occurrence of IBD and IC has been increasingly observed, possibly due to shared genetic structures. METHODS: A three-part analysis was executed utilizing genome-wide association study (GWAS) data on IBD and IC. First, the overall genetic …
The Interplay of Inflammatory Bowel Disease (IBD) and Diabetes in Pediatrics: A Systematic Review
Publication Year: 2024 Source: Cureus PMID: 39473672 DOI: 10.7759/cureus.70425
The main objective of this study is to provide insights into the clinical problems and considerations in managing pediatric patients with both diabetes and inflammatory bowel disease (IBD) by summarizing the available information. We conducted a comprehensive search across electronic resources, including ScienceDirect, PubMed, Cochrane Library, and Scopus. Two independent …
Serum Microcystin-LR Levels Linked with Risk of Inflammatory Bowel Disease: A Matched Case-Control Study in China
Publication Year: 2024 Source: Environ Health (Wash) PMID: 39473886 DOI: 10.1021/envhealth.3c00212
Microcystin-LR (MC-LR), the most prevalent and diverse cyanotoxin produced by harmful cyanobacterial blooms, has been linked to gastrointestinal toxicity. Therefore, we conducted a case-control study across four regions in China to investigate this relationship. Inflammatory bowel disease (IBD) cases (219) were matched with healthy controls (438) based on age and …
Non-targeted metabolomics and pseudo-targeted lipidomics combined with gut microbes reveal the protective effects of Causonis japonica (Thunb.) Raf. in ulcerative colitis mice
Publication Year: 2024 Source: Front Cell Infect Microbiol PMID: 39473926
No Abstract
A Comparative Study on the Effects of Mesenchymal Stem Cells and Their Conditioned Medium on Caco-2 Cells as an In Vitro Model for Inflammatory Bowel Disease
Publication Year: 2024 Source: Int J Cell Biol PMID: 39474054 DOI: 10.1155/2024/1022338
Recent research indicates that mesenchymal stem cells (MSCs), known for their anti-inflammatory and anti-infectious properties, could be a promising alternative for treating inflammatory diseases such as inflammatory bowel disease (IBD). This study examined how MSCs and their derivatives, when cocultured with interleukin-1beta (IL-1beta)-stimulated Caco-2 cells, affect the expression of genes …
Archaeogenetic analysis revealed East Eurasian paternal origin to the Aba royal family of Hungary
Publication Year: 2024 Source: iScience PMID: 39474080 DOI: 10.1016/j.isci.2024.110892
The Aba family played a pivotal role in Medieval Hungary, dominating vast territories and producing influential figures. We conducted an archaeogenetic study on remains from the necropolis in Abasar, the political center of the Aba clan, to identify family members and explore their genetic origins. Using Whole Genome Sequencing (WGS) …
A Real-World Comparison of Drug Trough Levels between Patients Experiencing a Secondary Nonimmune Loss of Response and Those Maintaining a Response to Infliximab on Long-Term Maintenance Therapy for Inflammatory Bowel Disease
Publication Year: 2024 Source: Inflamm Intest Dis PMID: 39474329 DOI: 10.1159/000541377
INTRODUCTION: A secondary loss of response (LOR) to infliximab (IFX) therapy for inflammatory bowel disease (IBD) is typically associated with low IFX trough levels, often with high levels of neutralizing antibodies to IFX (ATI). A small subset of patients on long-term therapy experience a "nonimmune" LOR, without ATI and with …
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