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Optimization of alginate/carboxymethyl chitosan microbeads for the sustained release of celecoxib and attenuation of intestinal inflammation in vitro
Publication Year: 2024 Source: Int J Biol Macromol PMID: 39476907 DOI: 10.1016/j.ijbiomac.2024.137022
Multiple anti-inflammatory medications have helped treat inflammatory bowel disease (IBD). However, oral administration has minimal absorption and systemic side effects. This study aims to investigate the potential of encapsulating anti-inflammatory drug celecoxib (Cele) within microbeads for the treatment of IBD. Microbeads were formed by cross-linking carboxymethyl chitosan (CMCs) with sodium …
Monoclonal antibody development and antigenic epitope identification of infectious bursal disease virus VP5
Publication Year: 2024 Source: Vet J PMID: 39477081 DOI: 10.1016/j.tvjl.2024.106254
Infectious bursal disease (IBD) is an important immunosuppressive disease affecting chickens and is caused by infectious bursal disease virus (IBDV) infection. VP5 is a non-essential protein for IBDV replication but plays a critical role in IBDV pathogenesis. A deeper understanding of the biological functions of VP5 is lacking. This study …
Mixed-method Irish study exploring the role of diet in IBD based on an online questionnaire and a patient panel opinion
Publication Year: 2024 Source: BMJ Open Gastroenterol PMID: 39477248 DOI: 10.1136/bmjgast-2023-001251
OBJECTIVE: Diet is a risk factor in inflammatory bowel diseases (IBD) pathogenesis. This study aims to examine the dietary patterns and beliefs of Irish patients living with IBD through an online questionnaire and subsequent open discussions with an IBD patient collaborator panel (PCP). All data presented here are selected and …
Patients and clinicians have different priorities when discussing pain in the IBD clinic
Publication Year: 2024 Source: BMJ Open Gastroenterol PMID: 39477249 DOI: 10.1136/bmjgast-2024-001540
OBJECTIVE: Pain in inflammatory bowel disease (IBD) is frequently neglected/overlooked, particularly in ulcerative colitis, and communication about pain can be suboptimal. The current study juxtaposes clinicians' conceptualisations of patients' pain with patient narratives. The aim was to inform the development of a pain reporting tool and provide guidance for better …
Biosynthetic enzyme analysis identifies a protective role for TLR4-acting gut microbial sulfonolipids in inflammatory bowel disease
Publication Year: 2024 Source: Nat Commun PMID: 39477928 DOI: 10.1038/s41467-024-53670-y
The trillions of microorganisms inhabiting the human gut are intricately linked to human health. While specific microbes have been associated with diseases, microbial abundance alone cannot reveal the molecular mechanisms involved. One such important mechanism is the biosynthesis of functional metabolites. Here, we develop a biosynthetic enzyme-guided disease correlation approach …
Single-cell transcriptomics of rectal organoids from individuals with perianal fistulizing Crohn's disease reveals patient-specific signatures
Publication Year: 2024 Source: Sci Rep PMID: 39477985
No Abstract
Gut microbiome: a biomedical revolution
Publication Year: 2024 Source: Nat Rev Gastroenterol Hepatol PMID: 39478172
No Abstract
Causal relationship between hypothyroidism and ulcerative colitis: a bidirectional Mendelian randomization study
Publication Year: 2024 Source: BMC Gastroenterol PMID: 39478467
No Abstract
Clinical assessment of small bowel capsule endoscopy in pediatric patients
Publication Year: 2024 Source: Front Med (Lausanne) PMID: 39478821
No Abstract
Effectiveness of biologic therapies in achieving treatment targets in inflammatory bowel disease; real-world data from the Middle East (ENROLL study)
Publication Year: 2024 Source: Front Pharmacol PMID: 39478964 DOI: 10.3389/fphar.2024.1388043
BACKGROUND: Real-world data assessing the effectiveness of biologics in patients with inflammatory bowel disease (IBD) in the Middle East are not well-established. In our study, we evaluated the effectiveness of biologic therapies in achieving clinical and endoscopic outcomes in biologic-naive patients with IBD. DESIGN: A retrospective chart review was conducted …
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