Research Articles Library
Literature Analysis Tools
Advanced Search
Filter by PMID, year, source, DOI and other criteria
Literature Analysis
Analyze research trends and hotspots
Batch Export
Export search results to Excel/PDF
Evaluation of the immunomodulatory activity of probiotics mixture and sulfasalazine against acetic acid-induced colitis in a murine model
Publication Year: 2024 Source: Mol Biol Rep PMID: 39419885 DOI: 10.1007/s11033-024-10008-7
BACKGROUND: Currently, the use of probiotics to treat inflammatory bowel diseases (IBD) is widely accepted because of their gut microbiota modulation capabilities and anti-inflammatory potential. OBJECTIVE: The aim of this study is to examine the immunomodulatory outcomes of probiotics and sulfasalazine in the acetic acid-induced colitis murine model. METHODS: The …
The phageome of patients with ulcerative colitis treated with donor fecal microbiota reveals markers associated with disease remission
Publication Year: 2024 Source: Nat Commun PMID: 39420033
No Abstract
Effectiveness of switching to subcutaneous infliximab in inflammatory bowel disease patients with inadequate biochemical response during intravenous administration
Publication Year: 2024 Source: Sci Rep PMID: 39420116 DOI: 10.1038/s41598-024-75693-7
Infliximab (IFX) has transformed the management of inflammatory bowel diseases (IBD). While intravenous (IV) IFX has been effective, a subcutaneous (SC) formulation offers advantages in convenience and cost. However, there is lack of evidence regarding the transition from IV to SC-IFX, especially for patients with inadequate responses. This study investigates …
N4BP3 facilitates NOD2-MAPK/NF-κB pathway in inflammatory bowel disease through mediating K63-linked RIPK2 ubiquitination
Publication Year: 2024 Source: Cell Death Discov PMID: 39420190 DOI: 10.1038/s41420-024-02213-x
The NOD2 signaling pathway, which plays an important role in the mechanisms of inflammatory bowel disease (IBD) development, has been closely associated with ubiquitination. It was revealed in this study that NOD2 receptor activation could obviously affect the expression of 19 ubiquitination-related genes, with N4BP3 being the most prominently expressed …
Layer by layer self-assembled hyaluronic acid nanoarmor for the treatment of ulcerative colitis
Publication Year: 2024 Source: J Nanobiotechnology PMID: 39420343
No Abstract
Exploring the management and treatment of IBD from the perspective of psychological comorbidities
Publication Year: 2024 Source: Therap Adv Gastroenterol PMID: 39421001 DOI: 10.1177/17562848241290685
The prevalence of anxiety, depression, and other psychological comorbidities among patients with inflammatory bowel disease (IBD) significantly exceeds that of the general population. Moreover, a bidirectional relationship exists between psychological comorbidities and IBD. This intricate interplay has substantial clinical implications, impacting treatment adherence, therapeutic efficacy, and disease recurrence rates. In …
Carriage of the HLA-DQA1⋆05 haplotype is associated with a higher risk of infratherapeutic drug concentration and higher immunogenicity in patients undergoing treatment with anti-TNF for inflammatory bowel disease
Publication Year: 2024 Source: Therap Adv Gastroenterol PMID: 39421002 DOI: 10.1177/17562848241278145
BACKGROUND: The success of anti-tumor necrosis factor (TNF) drug strategies in the treatment of inflammatory bowel disease (IBD) is altered by the development of anti-drug antibodies that reduce their efficacy. Studies have shown that the HLA-DQA1 small star, filled05 allele increases the risk of immunogenicity to anti-TNF drugs approximately twofold. …
Decoding the mosaic of inflammatory bowel disease: Illuminating insights with single-cell RNA technology
Publication Year: 2024 Source: Comput Struct Biotechnol J PMID: 39421242 DOI: 10.1016/j.csbj.2024.07.011
Inflammatory bowel diseases (IBD), comprising ulcerative colitis (UC) and Crohn's disease (CD), are complex chronic inflammatory intestinal conditions with a multifaceted pathology, influenced by immune dysregulation and genetic susceptibility. The challenges in understanding IBD mechanisms and implementing precision medicine include deciphering the contributions of individual immune and non-immune cell populations, …
Pangenomic analysis identifies correlations between Akkermansia species and subspecies and human health outcomes
Publication Year: 2024 Source: Microbiome Res Rep PMID: 39421249 DOI: 10.20517/mrr.2024.09
Aim: Akkermansia are common members of the human gastrointestinal microbiota. The prevalence of these mucophilic bacteria, especially Akkermansia muciniphila (A. muciniphila), correlates with immunological and metabolic health. The genus Akkermansia in humans includes species with significantly larger genomes than A. muciniphila, leading us to postulate that this added genetic content …
The Causal Relationship between Immune-Mediated Inflammatory Diseases and Aortic Aneurysm: A Bidirectional Two-Sample Mendelian Randomization Study
Publication Year: 2024 Source: J Immunol Res PMID: 39421304 DOI: 10.1155/2024/2474118
METHODS: We sourced genetic association data from public genome-wide association study databases for populations of European ancestry. Adhering to MR principles, we identified valid instrumental variables from genetic variants. A range of statistical methods were applied for MR analysis, with the inverse variance weighted (IVW) method emerging as the most …
Need more literature?
The current database contains 98453 research articles. If you need to search for more literature or perform AI analysis, please use our knowledge acquisition module or explore external literature resources.
External Resources: Access comprehensive literature databases worldwide