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Structure-function coupling changes in first-episode, treatment-naïve schizophrenia correlate with cell type-specific transcriptional signature
Publication Year: 2024 Source: BMC Med PMID: 39443976
No Abstract
Metaproteomics reveals diet-induced changes in gut microbiome function according to Crohn's disease location
Publication Year: 2024 Source: Microbiome PMID: 39443987 DOI: 10.1186/s40168-024-01927-5
BACKGROUND: Crohn's disease (CD) is characterized by chronic intestinal inflammation. Diet is a key modifiable factor influencing the gut microbiome (GM) and a risk factor for CD. However, the impact of diet modulation on GM function in CD patients is understudied. Herein, we evaluated the effect of a high-fiber, low-fat …
Hexokinase 2 expression in apical enterocytes correlates with inflammation severity in patients with inflammatory bowel disease
Publication Year: 2024 Source: BMC Med PMID: 39444028 DOI: 10.1186/s12916-024-03710-7
BACKGROUND: Inflammation is characterized by a metabolic switch promoting glycolysis and lactate production. Hexokinases (HK) catalyze the first reaction of glycolysis and inhibition of epithelial HK2 protected from colitis in mice. HK2 expression has been described as elevated in patients with intestinal inflammation; however, there is conflicting data from few …
Microbiota, metabolic profiles and immune biomarkers in infants receiving formula with added bovine milk fat globule membrane: a randomized, controlled trial
Publication Year: 2024 Source: Front Nutr PMID: 39444571
No Abstract
Immuno-therapeutic and prophylactic potential of Trichinella spiralis antigens for inflammatory bowel diseases
Publication Year: 2024 Source: Food Waterborne Parasitol PMID: 39444692 DOI: 10.1016/j.fawpar.2024.e00248
Ulcerative colitis (UC), a severe chronic inflammatory disorder of the colon, is one of the inflammatory bowel diseases (IBD) that affects humans and several domestic animal species, including cats and dogs. Helminth infections and autoimmune diseases are inversely correlated, as explained by the hygiene hypothesis, which suggests that IBD is …
Traces of Paleolithic expansion in the Nivkh gene pool based on data on autosomal SNP and Y chromosome polymorphism
Publication Year: 2024 Source: Vavilovskii Zhurnal Genet Selektsii PMID: 39445096 DOI: 10.18699/vjgb-24-73
The Nivkhs are a small ethnic group indigenous of the Russian Far East, living in the Khabarovsk Territory and on Sakhalin Island, descending from the ancient inhabitants of these territories. In the Nivkhs, a specific Sakhalin-Amur anthropological type is prevalent. They are quite isolated, due to long isolation from contacts …
Pediatric Crohn's Disease With Avoidant and Restrictive Food Intake Disorder (ARFID) Resulting in Failure to Thrive: A Case Report
Publication Year: 2024 Source: Cureus PMID: 39445255
No Abstract
Clinical Approach to STRIDE-II in Real-Life Settings: Analysis and Practical Recommendations
Publication Year: 2024 Source: Crohns Colitis 360 PMID: 39445340 DOI: 10.1093/crocol/otae055
BACKGROUND: We aimed to (1) analyze the applicability of the updated Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE-II) recommendations in real-world clinical practice, (2) identify barriers to their implementation, and (3) propose practical measures to overcome these obstacles. METHODS: This qualitative study was based on a survey, a literature …
Association of various symptoms and histological alterations in the diagnosis of pediatric ulcerative colitis
Publication Year: 2024 Source: Rev Esp Enferm Dig PMID: 39446092 DOI: 10.17235/reed.2024.10834/2024
Ulcerative colitis (UC) is a chronic, relapsing inflammatory bowel disease (IBD) of the colon. Its presentation is varied, with the main symptoms being mucosanguineous diarrhea, abdominal pain, and weight loss. However, the diagnostic utility of these symptoms in pediatric populations is controversial. This study evaluates the clinicopathological association of different …
MicroHDF: predicting host phenotypes with metagenomic data using a deep forest-based framework
Publication Year: 2024 Source: Brief Bioinform PMID: 39446191 DOI: 10.1093/bib/bbae530
The gut microbiota plays a vital role in human health, and significant effort has been made to predict human phenotypes, especially diseases, with the microbiota as a promising indicator or predictor with machine learning (ML) methods. However, the accuracy is impacted by a lot of factors when predicting host phenotypes …
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