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A novel approach to immune thrombocytopenia intervention: modulating intestinal homeostasis
Publication Year: 2024 Source: BMC Immunol PMID: 39449131 DOI: 10.1186/s12865-024-00660-w
Immune thrombocytopenia (ITP) is a prevalent hemorrhage condition that causes notable immune-related abnormalities. Recently discovered data has shown that the intestinal flora plays a crucial role in maintaining a balanced immune system. Furthermore, an imbalance in gut flora has the potential to increase the possibility of developing ITP. Moreover, some …
Exploring the Long-Term Effect of Artificial Sweeteners on Metabolic Health
Publication Year: 2024 Source: Cureus PMID: 39449954
No Abstract
Kaempferol enhances intestinal repair and inhibits the hyperproliferation of aging intestinal stem cells in Drosophila
Publication Year: 2024 Source: Front Cell Dev Biol PMID: 39450272
No Abstract
Association of Childhood Abuse With Incident Inflammatory Bowel Disease
Publication Year: 2024 Source: Clin Transl Gastroenterol PMID: 39450870 DOI: 10.14309/ctg.0000000000000718
INTRODUCTION: A link between inflammatory bowel disease (IBD), stressful life events, and psychological factors has previously been reported. Our objective was to examine the relationship between emotional, physical, and sexual abuse of childhood and risk of IBD using a large cohort of female health professionals. METHODS: We included participants in …
The Versatile Role of Peroxisome Proliferator-Activated Receptors in Immune-Mediated Intestinal Diseases
Publication Year: 2024 Source: Cells PMID: 39451206
No Abstract
Bromodomain-Containing 4 Is a Positive Regulator of Interleukin-34 Production in the Gut
Publication Year: 2024 Source: Cells PMID: 39451216 DOI: 10.3390/cells13201698
Experimental evidence suggests that, in the inflamed gut of inflammatory bowel disease (IBD) patients, interleukin-34 (IL-34) triggers detrimental signaling pathways. Factors/mechanisms regulating IL-34 production in IBD remain poorly characterized. Bromodomain-containing 4 (BRD4), a transcriptional and epigenetic regulator, is over-expressed in IBD, and studies in cancer cells suggest that BRD4 might …
Molecular Mechanisms of Skatole-Induced Inflammatory Responses in Intestinal Epithelial Caco-2 Cells: Implications for Colorectal Cancer and Inflammatory Bowel Disease
Publication Year: 2024 Source: Cells PMID: 39451248 DOI: 10.3390/cells13201730
Inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6), in intestinal epithelial cells significantly contribute to inflammatory bowel disease (IBD) and colorectal cancer (CRC). Given our previous findings that TNF-alpha is upregulated in intestinal epithelial Caco-2 cells induced by skatole, a tryptophan-derived gut microbiota metabolite, the present study …
Elastography as a Discriminator Between Fibrotic and Inflammatory Strictures in Crohn's Disease: A Dead End or Bright Future in Clinical Decision-Making? Critical Review
Publication Year: 2024 Source: Diagnostics (Basel) PMID: 39451622
No Abstract
The Impact of Gastrectomy on Inflammatory Bowel Disease Risk in Gastric Cancer Patients: A Critical Analysis
Publication Year: 2024 Source: Curr Oncol PMID: 39451734 DOI: 10.3390/curroncol31100430
Gastrectomy, a prevalent surgical procedure for gastric cancer, results in substantial alterations to the gastrointestinal tract, including reduced gastric acid production and significant modifications to the gut microbiota. These changes can impair postoperative recovery, influence metabolic functions, and predispose patients to inflammatory bowel disease (IBD). Studies have shown an increased …
Inflammatory Prostatitis Plus IBS-D Subtype and Correlation with Immunomodulating Agent Imbalance in Seminal Plasma: Novel Combined Treatment
Publication Year: 2024 Source: Diseases PMID: 39452503
No Abstract
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