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Novel bispecific nanobody mitigates experimental intestinal inflammation in mice by targeting TNF-α and IL-23p19 bioactivities
Publication Year: 2024 Source: Clin Transl Med PMID: 38533646 DOI: 10.1002/ctm2.1636
BACKGROUND: Inflammatory bowel diseases (IBDs) pose significant challenges in terms of treatment non-response, necessitating the development of novel therapeutic approaches. Although biological medicines that target TNF-alpha (tumour necrosis factor-alpha) have shown clinical success in some IBD patients, a substantial proportion still fails to respond. METHODS: We designed bispecific nanobodies (BsNbs) …
The Effect of an Electronic Medical Record-Based Clinical Decision Support System on Adherence to Clinical Protocols in Inflammatory Bowel Disease Care: Interrupted Time Series Study
Publication Year: 2024 Source: JMIR Med Inform PMID: 38533825 DOI: 10.2196/55314
BACKGROUND: Clinical decision support systems (CDSSs) embedded in electronic medical records (EMRs), also called electronic health records, have the potential to improve the adoption of clinical guidelines. The University of Alberta Inflammatory Bowel Disease (IBD) Group developed a CDSS for patients with IBD who might be experiencing disease flare and …
Response to Lin and Wei
Publication Year: 2024 Source: Am J Gastroenterol PMID: 38534001
No Abstract
Immunogenicity and Loss of Effectiveness of Biologic Therapy for Inflammatory Bowel Disease Patients Due to Anti-Drug Antibody Development
Publication Year: 2024 Source: Antibodies (Basel) PMID: 38534206 DOI: 10.3390/antib13010016
Many patients with inflammatory bowel disease (IBD) experience a loss of effectiveness to biologic therapy (i.e., anti-TNF therapy, etc.). Therefore, in addition to the adverse effects of the treatment, these patients also face failure to achieve and maintain remission. Immunogenicity, the process of production of antibodies to biological agents, is …
Border Control: The Role of the Microbiome in Regulating Epithelial Barrier Function
Publication Year: 2024 Source: Cells PMID: 38534321
No Abstract
Enterobacteriaceae in the Human Gut: Dynamics and Ecological Roles in Health and Disease
Publication Year: 2024 Source: Biology (Basel) PMID: 38534413
No Abstract
Mendelian Randomisation Analysis of Causal Association between Lifestyle, Health Factors, and Keratoconus
Publication Year: 2024 Source: Bioengineering (Basel) PMID: 38534495
No Abstract
Helicobacter pylori in Inflammatory Bowel Diseases: Active Protagonist or Innocent Bystander?
Publication Year: 2024 Source: Antibiotics (Basel) PMID: 38534702 DOI: 10.3390/antibiotics13030267
Helicobacter pylori (H. pylori) infection is a prominent entity within human infectious diseases which cause chronic gastritis, peptic ulcers, gastric malignancies, and extragastric disorders. Its persistent colonization can lead to a systemic inflammatory cascade, potentially instigating autoimmune responses and contributing to the pathogenesis of autoimmune diseases. While the specific etiopathogenesis …
The Opposite Functions of CD30 Ligand Isoforms
Publication Year: 2024 Source: Curr Issues Mol Biol PMID: 38534788
No Abstract
Functional Recovery and Regenerative Effects of Direct Transcutaneous Electrical Nerve Stimulation in Treatment of Post-COVID-19 Guillain-Barré and Acute Transverse Myelitis Overlap Syndrome: A Clinical Case
Publication Year: 2024 Source: J Funct Morphol Kinesiol PMID: 38535420
No Abstract
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