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CircSOD2: Disruption of intestinal mucosal barrier function in ulcerative colitis by regulating the miR-378g/Snail1 axis

Publication Year: 2024 Source: J Gastroenterol Hepatol PMID: 38646884

No Abstract

Long-term risk of delayed postoperative Crohn's disease recurrence in patients with no or mild endoscopic recurrence at first assessment

Publication Year: 2024 Source: Eur J Clin Invest PMID: 38647188

No Abstract

Work Productivity Impairment in Persons with Inflammatory Bowel Diseases: A Systematic Review and Meta-analysis

Publication Year: 2024 Source: J Crohns Colitis PMID: 38647194 DOI: 10.1093/ecco-jcc/jjae057

BACKGROUND AND AIMS: The impact of inflammatory bowel disease [IBD] on work productivity remains unclear. In this systematic review and meta-analysis, we quantify work-related outcomes and employment data among persons with IBD. METHODS: A systematic literature search was conducted in MEDLINE, EMBASE, the Cochrane library, Scopus, ProQuest, and clinicaltrials.gov from …

Both viable Bifidobacterium longum subsp. infantis B8762 and heat-killed cells alleviate the intestinal inflammation of DSS-induced IBD rats

Publication Year: 2024 Source: Microbiol Spectr PMID: 38647334 DOI: 10.1128/spectrum.03509-23

In view of the safety concerns of probiotics, more and more attention is paid to the beneficial effects of dead probiotics cells. Herein, we investigated and compared the alleviation effects of viable Bifidobacterium longum subsp. infantis B8762 (B. infantis B8762) and its heat-killed cells on dextran sodium sulfate (DSS)-induced inflammatory …

The "in between"

Publication Year: 2024 Source: Fam Syst Health PMID: 38647498 DOI: 10.1037/fsh0000819

When the authors were 12 and 14 years old, their worlds shifted suddenly without warning or consent, and bifurcated our lives into "a before" and "an after." They were both diagnosed with inflammatory bowel disease (IBD) and found themselves in an "in between" space-young but not healthy, sick but not …

Inhibiting the cGAS-STING Pathway in Ulcerative Colitis with Programmable Micelles

Publication Year: 2024 Source: ACS Nano PMID: 38648373

No Abstract

Sirt2 inhibition improves gut epithelial barrier integrity and protects mice from colitis

Publication Year: 2024 Source: Proc Natl Acad Sci U S A PMID: 38648480 DOI: 10.1073/pnas.2319833121

Sirt2 is a nicotinamide adenine dinucleotide (NAD(+))-dependent protein lysine deacylase that can remove both acetyl group and long-chain fatty acyl groups from lysine residues of many proteins. It was reported to affect inflammatory bowel disease (IBD) symptoms in a mouse model. However, conflicting roles were reported, with genetic knockout aggravating …

Fecal microbiota is associated with extraintestinal manifestations in inflammatory bowel disease

Publication Year: 2024 Source: Ann Med PMID: 38648495 DOI: 10.1080/07853890.2024.2338244

INTRODUCTION: A large proportion of patients with inflammatory bowel disease (IBD) experience IBD-related inflammatory conditions outside of the gastrointestinal tract, termed extraintestinal manifestations (EIMs) which further decreases quality of life and, in extreme cases, can be life threatening. The pathogenesis of EIMs remains unknown, and although gut microbiota alterations are …

Best Practice for Therapeutic Drug Monitoring of Infliximab: Position Statement from the International Association of Therapeutic Drug Monitoring and Clinical Toxicology

Publication Year: 2024 Source: Ther Drug Monit PMID: 38648666

No Abstract

Biochanin a ameliorates DSS-induced ulcerative colitis by improving colonic barrier function and protects against the development of spontaneous colitis in the Muc2 deficient mice

Publication Year: 2024 Source: Chem Biol Interact PMID: 38648921

No Abstract

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