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Higher Risk of Repeat Stone Surgery in Stone Formers With Concomitant Bowel Disease: Single-Center Long-Term Analysis
Publication Year: 2024 Source: Urology PMID: 38648946 DOI: 10.1016/j.urology.2024.04.008
OBJECTIVE: To identify the need for repeat stone surgery in patients with and without bowel disease. Few studies have compared risks between different types of bowel disease and whether their need for repeat stone surgery differs. METHODS: From our IRB-approved study, we identified patients with and without bowel disease. We …
Inhibition of METTL3 in macrophages provides protection against intestinal inflammation
Publication Year: 2024 Source: Cell Mol Immunol PMID: 38649449 DOI: 10.1038/s41423-024-01156-8
Inflammatory bowel disease (IBD) is prevalent, and no satisfactory therapeutic options are available because the mechanisms underlying its development are poorly understood. In this study, we discovered that increased expression of methyltransferase-like 3 (METTL3) in macrophages was correlated with the development of colitis and that depletion of METTL3 in macrophages …
Image-based assessment of aortoiliac aneurysm anatomical characteristics in patients from the global iliac branch study
Publication Year: 2024 Source: Langenbecks Arch Surg PMID: 38649506 DOI: 10.1007/s00423-024-03326-8
OBJECTIVE: Endovascular repair is the preferred treatment for aortoiliac aneurysm, with preservation of at least one internal iliac artery recommended. This study aimed to assess pre-endovascular repair anatomical characteristics of aortoiliac aneurysm in patients from the Global Iliac Branch Study (GIBS, NCT05607277) to enhance selection criteria for iliac branch devices …
Dissecting the respective roles of microbiota and host genetics in the susceptibility of Card9(-/-) mice to colitis
Publication Year: 2024 Source: Microbiome PMID: 38649950 DOI: 10.1186/s40168-024-01798-w
BACKGROUND: The etiology of inflammatory bowel disease (IBD) is unclear but involves both genetics and environmental factors, including the gut microbiota. Indeed, exacerbated activation of the gastrointestinal immune system toward the gut microbiota occurs in genetically susceptible hosts and under the influence of the environment. For instance, a majority of …
Ectopic colonization by oral bacteria as an emerging theme in health and disease
Publication Year: 2024 Source: FEMS Microbiol Rev PMID: 38650052
No Abstract
Magnetic resonance enterography findings 46 weeks after initiation of biological therapy predict long-term adverse outcomes in Crohn's disease
Publication Year: 2024 Source: Aliment Pharmacol Ther PMID: 38650481
No Abstract
Sishen Pill and its active phytochemicals in treating inflammatory bowel disease and colon cancer: an overview
Publication Year: 2024 Source: Front Pharmacol PMID: 38650627 DOI: 10.3389/fphar.2024.1375585
The incidence of inflammatory bowel disease (IBD) and the associated risk of colon cancer are increasing globally. Traditional Chinese medicine (TCM) treatment has unique advantages. The Sishen Pill, a common Chinese patented drug used to treat abdominal pain and diarrhea, consists mainly of Psoraleae Fructus, Myristicae Semen, Euodiae Fructus, and …
Genomic testing identifies monogenic causes in patients with very early-onset inflammatory bowel disease: a multicenter survey in an Iranian cohort
Publication Year: 2024 Source: Clin Exp Immunol PMID: 38651248 DOI: 10.1093/cei/uxae037
Patients with very early-onset inflammatory bowel disease (VEO-IBD) may present because of underlying monogenic inborn errors of immunity (IEI). Strong differences have been observed in the causes of monogenic IBD among ethnic populations. This multicenter study was carried out on 16 Iranian patients with VEO-IBD. We reviewed clinical and basic …
Risk factors for surgery in stricturing small bowel Crohn's disease: A retrospective cohort study from the GETAID pédiatrique
Publication Year: 2024 Source: J Pediatr Gastroenterol Nutr PMID: 38651614 DOI: 10.1002/jpn3.12224
OBJECTIVES: Previous studies have shown rates of surgical resection of up to 41% in stricturing pediatric Crohn's disease (CD). In this retrospective multicenter study, our aims were to identify clinical risk factors and magnetic resonance enterography (MRE) features of small bowel strictures associated with surgery. METHODS: Pediatric patients with symptomatic …
Predictors of irritable bowel syndrome-like symptoms in quiescent inflammatory bowel disease
Publication Year: 2024 Source: Neurogastroenterol Motil PMID: 38651743 DOI: 10.1111/nmo.14809
BACKGROUND: Many patients with quiescent inflammatory bowel disease (IBD) suffer from irritable bowel syndrome (IBS)-like symptoms. Although these symptoms cause significant reductions in quality of life, evidence-based treatments are lacking as risk factors and pathophysiology of these symptoms are not clearly defined. We aimed to identify risk factors for development …
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