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Diagnosis change in pediatric inflammatory bowel disease

Publication Year: 2024 Source: J Pediatr Gastroenterol Nutr PMID: 38504401 DOI: 10.1002/jpn3.12120

OBJECTIVES: This study aims to characterize pediatric inflammatory bowel disease (IBD) patients who change diagnosis and describe the characteristics of that change. METHODS: A retrospective study was conducted on pediatric IBD patients from the ImproveCareNow (ICN) multicenter international cohort from 2007 to January 2019. Primary outcome was change in diagnosis …

Top 10 research priorities for digital technology for adolescents and young persons with inflammatory bowel disease: Results of a James Lind Alliance Priority Setting Partnership

Publication Year: 2024 Source: J Pediatr Gastroenterol Nutr PMID: 38504402 DOI: 10.1002/jpn3.12105

OBJECTIVES: Priority Setting Partnerships (PSP's) using the James Lind Alliance (JLA) methodology, bring together health professionals, patients and parents/carers to identify and prioritise unanswered questions that can be addressed by future research projects. To identify and prioritise the top 10 unanswered research priorities in digital technology for adolescents and young …

Role of peripheral and tissue eosinophils and eosinophil cationic protein in pediatric inflammatory bowel disease

Publication Year: 2024 Source: J Pediatr Gastroenterol Nutr PMID: 38504407 DOI: 10.1002/jpn3.12076

OBJECTIVES: Inflammatory bowel disease (IBD), eosinophilic gastrointestinal disease (EGID), and functional abdominal pain disorder (FAPD) present with nonspecific gastrointestinal (GI) symptoms clinically and also have some similarities in pathogeneses associated with eosinophils. Therefore, we aimed to evaluate the role of eosinophils in IBD compared to EGID and FAPD by investigating …

Digital spatial profiling identifies molecular changes involved in development of colitis-associated colorectal cancer

Publication Year: 2024 Source: Front Oncol PMID: 38505585 DOI: 10.3389/fonc.2024.1247106

OBJECTIVE: Chronic colonic inflammation seen in inflammatory bowel disease (IBD) is a risk factor for colorectal cancer (CRC). Colitis-associated cancers (CAC) are molecularly different from sporadic CRC. This study aimed to evaluate spatially defined molecular changes associated with neoplastic progression to identify mechanisms of action and potential biomarkers for prognostication. …

Role of autoantibodies in the pathophysiology of irritable bowel syndrome: a review

Publication Year: 2024 Source: Front Physiol PMID: 38505711

No Abstract

Dietary therapies for adult and pediatric inflammatory bowel disease

Publication Year: 2024 Source: Nutr Clin Pract PMID: 38505875 DOI: 10.1002/ncp.11146

Diet is an environmental exposure implicated in the development of inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC). Dietary therapy is also a tool for management of these conditions. Nutrition therapy for IBD has been shown to reduce intestinal inflammation, promote healing, and alleviate symptoms, as …

Plasma bile acids in association with Crohn's disease

Publication Year: 2024 Source: Scand J Gastroenterol PMID: 38505982

No Abstract

Histological Outcomes and JAK-STAT Signalling in Ulcerative Colitis Patients Treated with Tofacitinib

Publication Year: 2024 Source: J Crohns Colitis PMID: 38506097

No Abstract

Anti-inflammatory probiotics HF05 and HF06 synergistically alleviate ulcerative colitis and secondary liver injury

Publication Year: 2024 Source: Food Funct PMID: 38506656

No Abstract

Dietary fiber is a critical determinant of pathologic ILC2 responses and intestinal inflammation

Publication Year: 2024 Source: J Exp Med PMID: 38506708 DOI: 10.1084/jem.20232148

Innate lymphoid cells (ILCs) can promote host defense, chronic inflammation, or tissue protection and are regulated by cytokines and neuropeptides. However, their regulation by diet and microbiota-derived signals remains unclear. We show that an inulin fiber diet promotes Tph1-expressing inflammatory ILC2s (ILC2INFLAM) in the colon, which produce IL-5 but not …

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