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The Effect of Polymorphisms and Other Biomarkers on Infliximab Exposure in Paediatric Inflammatory Bowel Disease: Development of a Population Pharmacokinetic Model
Publication Year: 2024 Source: Paediatr Drugs PMID: 38507036 DOI: 10.1007/s40272-024-00621-1
BACKGROUND: Therapeutic drug monitoring (TDM) of infliximab has been shown to be a effective strategy for inflammatory bowel disease (IBD). Population pharmacokinetic (PopPK) modeling can predict trough concentrations for individualized dosing. OBJECTIVE: The aim of this study was to develop a PopPK model of infliximab in a paediatric population with …
Strictureplasty may lead to increased preference in the surgical management of Crohn's disease: a case-matched study
Publication Year: 2024 Source: Tech Coloproctol PMID: 38507096
No Abstract
IBD in women of reproductive age: where do novel therapies fit in?
Publication Year: 2024 Source: Expert Rev Gastroenterol Hepatol PMID: 38507228 DOI: 10.1080/17474124.2024.2334039
No Abstract
Specific deletion of Mettl3 in IECs triggers the development of spontaneous colitis and dysbiosis of T lymphocytes in mice
Publication Year: 2024 Source: Clin Exp Immunol PMID: 38507548 DOI: 10.1093/cei/uxae025
The enzymatic core component of m6A writer complex, Mettl3, plays a crucial role in facilitating the development and progress of gastric and colorectal cancer (CRC). However, its underlying mechanism in regulating intestinal inflammation remains unclear and poorly investigated. First, the characteristics of Mettl3 expression in inflammatory bowel diseases (IBD) patients …
Lack of ATP2B1 in CD4+ T Cells Causes Colitis
Publication Year: 2024 Source: Inflamm Bowel Dis PMID: 38507609
No Abstract
Corrigendum to: Influence of Early Life Factors, including breast milk Composition, on the Microbiome of Infants Born to Mothers with and without Inflammatory Bowel Disease
Publication Year: 2024 Source: J Crohns Colitis PMID: 38507613
No Abstract
Phenolic acids from Chicory roots ameliorate dextran sulfate sodium-induced colitis in mice by targeting TRP signaling pathways and the gut microbiota
Publication Year: 2024 Source: Phytomedicine PMID: 38507851 DOI: 10.1016/j.phymed.2024.155378
BACKGROUND: Inflammatory bowel disease (IBD) is a type of immune-mediated condition associated with intestinal homeostasis. Our preliminary studies disclosed that Cichorium intybus L., a traditional medicinal plant, also known as Chicory in Western countries, contained substantial phenolic acids displaying significant anti-inflammatory activities. We recognized the potential of harnessing Chicory for …
Severe Fatigue in Inflammatory Bowel Disease: Dopaminergic Therapy With Modafinil or Vitamin Therapy With Thiamine
Publication Year: 2024 Source: Clin Gastroenterol Hepatol PMID: 38508480 DOI: 10.1016/j.cgh.2024.03.002
We found Moulton et al's(1) illustrative case series of 10 patients with inflammatory bowel disease (IBD) and chronic fatigue, all presenting with depression, particularly interesting. (1) Among the patients, 8 previously had undergone treatment with multiple psychotropic medications, and 2 had active IBD as indicated by increased fecal calprotectin levels. …
Assessment of the Inflammatory Effects of Gut Microbiota from Human Twins Discordant for Ulcerative Colitis on Germ-free Mice
Publication Year: 2024 Source: Comp Med PMID: 38508697 DOI: 10.30802/AALAS-CM-23-000065
Disturbances in gut microbiota are prevalent in inflammatory bowel disease (IBD), which includes ulcerative colitis (UC). However, whether these disturbances contribute to development of the disease or are a result of the disease is unclear. In pairs of human twins discordant for IBD, the healthy twin has a higher risk …
Strong positive selection biases identity-by-descent-based inferences of recent demography and population structure in Plasmodium falciparum
Publication Year: 2024 Source: Nat Commun PMID: 38509066 DOI: 10.1038/s41467-024-46659-0
Malaria genomic surveillance often estimates parasite genetic relatedness using metrics such as Identity-By-Decent (IBD), yet strong positive selection stemming from antimalarial drug resistance or other interventions may bias IBD-based estimates. In this study, we use simulations, a true IBD inference algorithm, and empirical data sets from different malaria transmission settings …
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