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Cohort Profile Update: The Québec Birth Cohort on Immunity and Health (CO·MMUNITY)
Publication Year: 2024 Source: Int J Epidemiol PMID: 38365966
No Abstract
Peripheral Joint and Enthesis Involvement in Patients With Newly Diagnosed Inflammatory Bowel Disease: Symptoms, and Clinical and Ultrasound Findings - A Population-Based Cohort Study
Publication Year: 2024 Source: J Crohns Colitis PMID: 38366120 DOI: 10.1093/ecco-jcc/jjae022
OBJECTIVES: Musculoskeletal [MSK] manifestations in patients with inflammatory bowel disease [IBD] are common and associated with poorer outcomes. Hence, early detection is important to optimally tailor treatment. We aimed to determine the prevalence and distribution of inflammatory lesions in peripheral joints and entheses in newly diagnosed IBD patients. DESIGN: Patients …
Thiopurine Metabolite Shunting in Late Pregnancy Increases the Risk of Intrahepatic Cholestasis of Pregnancy in Women With Inflammatory Bowel Disease, and Can be Managed With Split Dosing
Publication Year: 2024 Source: J Crohns Colitis PMID: 38366352
No Abstract
Efficacy and Safety of Filgotinib for the Treatment of Perianal Fistulising Crohn's Disease [DIVERGENCE 2]: A Phase 2, Randomised, Placebo-controlled Trial
Publication Year: 2024 Source: J Crohns Colitis PMID: 38366672
No Abstract
Health Services Utilization and Specialist Care in Pediatric Inflammatory Bowel Disease: A Multiprovince Population-Based Cohort Study
Publication Year: 2024 Source: Inflamm Bowel Dis PMID: 38366807 DOI: 10.1093/ibd/izae010
BACKGROUND: Patterns of health services utilization among children with inflammatory bowel disease (IBD) are important to understand as the number of children with IBD continues to increase. We compared health services utilization and surgery among children diagnosed <10 years of age (Paris classification: A1a) and between 10 and <16 years …
The Phospholipid Flippase ATP8B1 is Involved in the Pathogenesis of Ulcerative Colitis via Establishment of Intestinal Barrier Function
Publication Year: 2024 Source: J Crohns Colitis PMID: 38366839 DOI: 10.1093/ecco-jcc/jjae024
AIMS: Patients with mutations in ATP8B1 develop progressive familial intrahepatic cholestasis type 1 [PFIC1], a severe liver disease that requires life-saving liver transplantation. PFIC1 patients also present with gastrointestinal problems, including intestinal inflammation and diarrhoea, which are aggravated after liver transplantation. Here we investigate the intestinal function of ATP8B1 in …
Associations of Fish and Fish Oil Consumption With Incident Inflammatory Bowel Disease: A Population-Based Prospective Cohort Study
Publication Year: 2024 Source: Inflamm Bowel Dis PMID: 38366853
No Abstract
Lymphocytic colitis can be transcriptionally divided into channelopathic and inflammatory lymphocytic colitis
Publication Year: 2024 Source: United European Gastroenterol J PMID: 38366868 DOI: 10.1002/ueg2.12531
BACKGROUND: The pathobiology of the non-destructive inflammatory bowel disease (IBD) lymphocytic colitis (LC) is poorly understood. We aimed to define an LC-specific mucosal transcriptome to gain insight into LC pathology, identify unique genomic signatures, and uncover potentially druggable disease pathways. METHODS: We performed bulk RNA-sequencing of LC and collagenous colitis …
Clostridium perfringens: A Potential Pathobiont in Inflammatory Bowel Disease
Publication Year: 2024 Source: J Crohns Colitis PMID: 38366889
No Abstract
Pragmatic Trial Design to Compare Real-world Effectiveness of Different Treatments for Inflammatory Bowel Diseases: The PRACTICE-IBD European Consensus
Publication Year: 2024 Source: J Crohns Colitis PMID: 38367197 DOI: 10.1093/ecco-jcc/jjae026
BACKGROUND AND AIMS: Pragmatic studies designed to test interventions in everyday clinical settings can successfully complement the evidence from registration and explanatory clinical trials. The European consensus project PRACTICE-IBD was developed to identify essential criteria and address key methodological issues needed to design valid, comparative, pragmatic studies in inflammatory bowel …
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