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Specific Antibiotics Increase the Risk of Flare-Ups in Patients with Inflammatory Bowel Disease: Results from a Danish Nationwide Population-Based Nested Case-Control Study
Publication Year: 2024 Source: J Crohns Colitis PMID: 38367201 DOI: 10.1093/ecco-jcc/jjae027
INTRODUCTION: Inflammatory bowel disease [IBD] patients have a relapsing-remitting disease course, and amongst environmental factors that aggravate the disease course, common drugs aside from non-steroidal anti-inflammatory drugs have not been studied in detail. While the microbiome is considered to play a significant role on the disease course, the impact of …
Crohn's Patient Serum Proteomics Reveals Response Signature for Infliximab but not Vedolizumab
Publication Year: 2024 Source: Inflamm Bowel Dis PMID: 38367209
No Abstract
Telmisartan loading thermosensitive hydrogel repairs gut epithelial barrier for alleviating inflammatory bowel disease
Publication Year: 2024 Source: Colloids Surf B Biointerfaces PMID: 38367290 DOI: 10.1016/j.colsurfb.2024.113799
Inflammatory bowel disease (IBD) remains a global health concern with a complex and incompletely understood pathogenesis. In the course of IBD development, damage to intestinal epithelial cells and a reduction in the expression of tight junction (TJ) proteins compromise the integrity of the intestinal barrier, exacerbating inflammation. Notably, the renin-angiotensin …
Non-electrophysiological techniques targeting transient receptor potential (TRP) gene of gastrointestinal tract
Publication Year: 2024 Source: Int J Biol Macromol PMID: 38367416 DOI: 10.1016/j.ijbiomac.2024.129551
Transient receptor potential (TRP) channels are cation channels related to a wide range of physical and chemical stimuli, they are expressed all along the gastrointestinal system, and a myriad of diseases are often associated with aberrant expression or mutation of the TRP gene, suggesting that TRPs are promising targets for …
Macrophage β-arrestin-1 deteriorates DSS-induced colitis through interaction with NF-κB signaling
Publication Year: 2024 Source: Int Immunopharmacol PMID: 38367465
No Abstract
Microbiome and its relevance to indigenous inflammatory bowel diseases in China
Publication Year: 2024 Source: Gene PMID: 38367851 DOI: 10.1016/j.gene.2024.148257
BACKGROUND: Inflammatory Bowel Disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract with an unknown etiology. Although dysbiosis is implicated in its pathogenesis, deep sequencing and oral microbiota study in Chinese IBD patients is absent. AIM: To explore the role of oral / intestinal microbiota in patients with …
The ERK-cPLA2-ACSL4 axis mediating M2 macrophages ferroptosis impedes mucosal healing in ulcerative colitis
Publication Year: 2024 Source: Free Radic Biol Med PMID: 38367927
No Abstract
Tacrolimus-Associated Terminal Ileitis After Kidney Transplantation, Mimicking Crohn Disease: A Case Report
Publication Year: 2024 Source: Transplant Proc PMID: 38368132 DOI: 10.1016/j.transproceed.2023.12.015
The onset of gastroduodenal ulcers is a frequent complication after transplantation, whereas cases of intestinal ulcers are sporadic and poorly described in the literature. A patient on immunosuppressive therapy with tacrolimus and mycophenolate mofetil after kidney transplant for immunoglobulin A-related glomerulonephritis developed symptoms compatible with Crohn disease 7 months after …
Anal incontinence after obstetrical anal sphincter injury significantly impacts quality of life for women: a cohort study
Publication Year: 2024 Source: Langenbecks Arch Surg PMID: 38368278
No Abstract
Mucosal host-microbe interactions associate with clinical phenotypes in inflammatory bowel disease
Publication Year: 2024 Source: Nat Commun PMID: 38368394 DOI: 10.1038/s41467-024-45855-2
Disrupted host-microbe interactions at the mucosal level are key to the pathophysiology of IBD. This study aimed to comprehensively examine crosstalk between mucosal gene expression and microbiota in patients with IBD. To study tissue-specific interactions, we perform transcriptomic (RNA-seq) and microbial (16S-rRNA-seq) profiling of 697 intestinal biopsies (645 derived from …
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