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A new surgical technique: robotic intracorporeal Kono-S anastomosis in Crohn's - a safety and feasibility case series on short-term outcomes
Publication Year: 2024 Source: Colorectal Dis PMID: 38369963 DOI: 10.1111/codi.16914
AIM: The Kono-S anastomosis was introduced as a possible solution to the high surgical recurrence rates in Crohn's disease. However, this technique is known to be challenging, which is why it was originally performed in an extracorporeal setting. The aim of this case series was to assess safety, in terms …
Adverse events of biologic or small molecule therapies in clinical trials for inflammatory bowel disease: A systematic review and meta-analysis
Publication Year: 2024 Source: Heliyon PMID: 38370239 DOI: 10.1016/j.heliyon.2024.e25357
BACKGROUND: Biologic or small-molecule therapies are highly effective for the treatment of inflammatory bowel disease (IBD), and approval by the FDA has significantly increased both their clinical use and the development of novel regimens. However, the identification and management of their associated toxicities poses challenges for clinicians and researchers. METHODS: …
Hydrogen Regulates Ulcerative Colitis by Affecting the Intestinal Redox Environment
Publication Year: 2024 Source: J Inflamm Res PMID: 38370464
No Abstract
Genomics reveals heterogeneous Plasmodium falciparum transmission and population differentiation in Zambia and bordering countries
Publication Year: 2024 Source: medRxiv PMID: 38370674 DOI: 10.1101/2024.02.09.24302570
Genomic surveillance plays a critical role in monitoring malaria transmission and understanding how the parasite adapts in response to interventions. We conducted genomic surveillance of malaria by sequencing 241 Plasmodium falciparum genomes from regions with varying levels of malaria transmission across Zambia. We found genomic evidence of high levels of …
A meta-analysis of the gut microbiome in inflammatory bowel disease patients identifies disease-associated small molecules
Publication Year: 2024 Source: bioRxiv PMID: 38370680 DOI: 10.1101/2024.02.07.579278
Changes in the gut microbiome have been associated with several human diseases, but the molecular and functional details underlying these associations remain largely unknown. Here, we performed a multi-cohort analysis of small molecule biosynthetic gene clusters (BGCs) in 5,306 metagenomic samples of the gut microbiome from 2,033 Inflammatory Bowel Disease …
TNF promoter hypomethylation is associated with mucosal inflammation in IBD and anti-TNF response
Publication Year: 2024 Source: medRxiv PMID: 38370739 DOI: 10.1101/2024.02.05.24302343
BACKGROUND AND AIMS: Inflammatory Bowel Diseases (IBD) are chronic inflammatory conditions influenced heavily by environmental factors. DNA methylation is a form of epigenetic regulation linking environmental stimuli to gene expression changes and inflammation. Here, we investigated how DNA methylation of the TNF promoter differs between inflamed and uninflamed mucosa of …
Achy Breaky Heart: A Rare Case of Myopericarditis Secondary to Mesalamine in a Patient With Inflammatory Bowel Disease
Publication Year: 2024 Source: Cureus PMID: 38370999 DOI: 10.7759/cureus.52587
Mesalamine is a first-line drug used in the treatment of inflammatory bowel disease (IBD), specifically ulcerative colitis (UC), with side effects ranging from gastrointestinal effects to cardiotoxicity. We present a rare case of mesalamine-induced myopericarditis in a patient with IBD, who presented with epigastric pain and was found to have …
Salmonella Group B Ileitis Mimicking Crohn's Disease: A Case Report
Publication Year: 2024 Source: Cureus PMID: 38371045
No Abstract
Colonic ketogenesis, a microbiota-regulated process, contributes to blood ketones and protects against colitis in mice
Publication Year: 2024 Source: Biochem J PMID: 38372391
No Abstract
Meta-analysis: Risk of pancreatic cancer in patients with inflammatory bowel disease
Publication Year: 2024 Source: Aliment Pharmacol Ther PMID: 38372406 DOI: 10.1111/apt.17919
BACKGROUND: Studies exploring the association between inflammatory bowel disease (IBD) and pancreatic cancer have reported inconsistent results. AIMS: To provide a comprehensive overview of the risk of pancreatic cancer development in patients with IBD. METHODS: We searched Embase, PubMed, Scopus and ProQuest from inception to 31 October 2023. We included …
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