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Fractal analysis of extracellular matrix for observer-independent quantification of intestinal fibrosis in Crohn's disease
Publication Year: 2024 Source: Sci Rep PMID: 38368499
No Abstract
Mineralocorticoid promotes intestinal inflammation through receptor dependent IL17 production in ILC3s
Publication Year: 2024 Source: Int Immunopharmacol PMID: 38368773 DOI: 10.1016/j.intimp.2024.111678
Aldosterone is a key mineralocorticoid involved in regulating the concentration of blood electrolytes and physiological volume balance. Activation of mineralocorticoid receptor (MR) has been recently reported to participate in adaptive and innate immune responses under inflammation. Here, we evaluated the role of aldosterone and MR in inflammation bowel diseases (IBD). …
Epithelial-neuronal-immune cell interactions: Implications for immunity, inflammation, and tissue homeostasis at mucosal sites
Publication Year: 2024 Source: J Allergy Clin Immunol PMID: 38369030
No Abstract
Genetic Variation Between Small Bowel and Colon-Predominant Crohn's Disease
Publication Year: 2024 Source: Cell Mol Gastroenterol Hepatol PMID: 38369131
No Abstract
The intestinal microbial metabolite acetyl l-carnitine improves gut inflammation and immune homeostasis via CADM2
Publication Year: 2024 Source: Biochim Biophys Acta Mol Basis Dis PMID: 38369215 DOI: 10.1016/j.bbadis.2024.167089
Intestinal symbiotic bacteria play a key role in the regulation of immune tolerance in inflammatory bowel disease (IBD) hosts. However, the bacterial strains directly involved in this regulation and their related metabolites are largely unknown. We sought to investigate the effects of intestinal microbial metabolites on intestinal epithelium and to …
Long-Term Effectiveness and Durability of COVID-19 Vaccination Among Patients With Inflammatory Bowel Disease
Publication Year: 2024 Source: Clin Gastroenterol Hepatol PMID: 38369224 DOI: 10.1016/j.cgh.2024.02.001
BACKGROUND AND AIMS: COVID-19 vaccination prevents severe disease in most patients with inflammatory bowel disease (IBD), but immunosuppressive medications can blunt serologic response. We followed adults with IBD for >1 year post-COVID-19 vaccination to describe factors associated with SARS-CoV-2 infection after vaccination, evaluate for a protective SARS-CoV-2 antibody level, characterize …
Comparison of the Effectiveness of Vedolizumab and Ustekinumab in Crohn's Disease Patients Who Failed Anti-tumor Necrosis Factor-α Treatment in Japan: An Observational Study Utilizing Claims Database
Publication Year: 2024 Source: Biol Pharm Bull PMID: 38369343
No Abstract
Deficits in geriatric assessment are important in relation to fatigue in older patients with Inflammatory Bowel Disease
Publication Year: 2024 Source: Dig Liver Dis PMID: 38369409 DOI: 10.1016/j.dld.2024.01.196
BACKGROUND: No previous study has investigated fatigue in older patients with Inflammatory Bowel Disease (IBD). AIMS: To describe the prevalence of fatigue in older patients and compare it to the prevalence in younger patients with IBD, and to determine factors associated with fatigue. METHODS: A prospective, multicenter cohort study, including …
Genetic biomarkers of methotrexate response and safety in Crohn's disease: Data from the Spanish ENEIDA registry
Publication Year: 2024 Source: Br J Clin Pharmacol PMID: 38369687
No Abstract
Plant-derived vesicle-like nanoparticles: A new tool for inflammatory bowel disease and colitis-associated cancer treatment
Publication Year: 2024 Source: Mol Ther PMID: 38369751 DOI: 10.1016/j.ymthe.2024.02.021
Long-term use of conventional drugs to treat inflammatory bowel diseases (IBD) and colitis-associated cancer (CAC) has an adverse impact on the human immune system and easily leads to drug resistance, highlighting the urgent need to develop novel biotherapeutic tools with improved activity and limited side effects. Numerous products derived from …
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