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Gut bacteriome in inflammatory bowel disease: An update on recent advances

Publication Year: 2024 Source: Indian J Gastroenterol PMID: 38374283 DOI: 10.1007/s12664-024-01541-1

Inflammatory bowel diseases (IBD) are chronic inflammatory gut disorders, majorly classified as ulcerative colitis and Crohn's disease. The complex, multifactorial etiopathogenesis of IBD involves genetic predisposition, environmental cues, aberrant mucosal immune response and a disturbed gut microbiota. Epidemiological trends, studies in gnotobiotic mice models and genome-wide association studies, identifying genes …

The regulation and differentiation of regulatory T cells and their dysfunction in autoimmune diseases

Publication Year: 2024 Source: Nat Rev Immunol PMID: 38374298

No Abstract

Is extended venous thromboprophylaxis required in patients undergoing ileal pouch procedure for ulcerative colitis?

Publication Year: 2024 Source: Colorectal Dis PMID: 38374529

No Abstract

Fatigue in pediatric inflammatory bowel diseases: A systematic review and a single center experience

Publication Year: 2024 Source: J Pediatr Gastroenterol Nutr PMID: 38374545 DOI: 10.1002/jpn3.12039

OBJECTIVES: We aimed to review the literature on fatigue in pediatric inflammatory bowel diseases (PIBD), to explore how it is measured, and approximate its rate in an inception pediatric cohort. METHODS: Studies on fatigue were systematically reviewed and selected by two authors. Next, we retrieved the two fatigue-related questions of …

Evaluation of acute terminal ileitis in children before and during the COVID-19 pandemic

Publication Year: 2024 Source: J Pediatr Gastroenterol Nutr PMID: 38374549

OBJECTIVES: The aim of this study was to examine the clinical features of acute terminal ileitis in children and evaluate its rate before and during the COVID-19 pandemic. METHODS: This retrospective study was performed in our pediatric emergency department between 2018 and 2022. The records of 5363 patients who required …

Diagnostic accuracy of multimodal noninvasive follow-up for pediatric ulcerative colitis: A single-center prospective study

Publication Year: 2024 Source: J Pediatr Gastroenterol Nutr PMID: 38374550 DOI: 10.1002/jpn3.12098

OBJECTIVES: Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) often requiring endoscopic evaluations, which can be uncomfortable and costly, especially for children. This study aimed to evaluate the diagnostic accuracy of a noninvasive approach combining fecal calprotectin (FCP), colonic ultrasonography (US), and colon capsule endoscopy (CCE) compared with …

Precision nutrition in pediatric IBD: A position paper from the ESPGHAN special interest group for basic science and translational research, the IBD Porto group, and allied health professionals

Publication Year: 2024 Source: J Pediatr Gastroenterol Nutr PMID: 38374554 DOI: 10.1002/jpn3.12096

Stratified and precision nutrition refers to disease management or prevention of disease onset, based on dietary interventions tailored to a person's characteristics, biology, gut microbiome, and environmental exposures. Such treatment models may lead to more effective management of inflammatory bowel disease (IBD) and reduce risk of disease development. This societal …

Anti-infliximab antibodies and low infliximab levels correlate with drug discontinuation in pediatric inflammatory bowel disease

Publication Year: 2024 Source: J Pediatr Gastroenterol Nutr PMID: 38374555 DOI: 10.1002/jpn3.12074

BACKGROUND: Infliximab (IFX) use is limited by loss of response often due to the development of anti-IFX antibodies and low drug levels. METHODS: We performed a single center prospective observational cohort study of pediatric and young adult subjects with inflammatory bowel disease (IBD) on IFX with over 3 years of …

Can vulvar edema be the presenting sign of Crohn's disease? A case series

Publication Year: 2024 Source: J Pediatr Gastroenterol Nutr PMID: 38374559

Vulvar involvement as an extraintestinal manifestation of Crohn's disease (CD) is a challenging diagnosis considering that vaginal findings may precede gastrointestinal symptoms. The aim of this study is to describe the clinical presentation, radiological findings, and treatment of vulvar Crohn's disease (VCD). We reviewed the time from initial presentation to …

Bone health screening practices with dual-energy X-ray absorptiometry and prediction of abnormal results in pediatric inflammatory bowel disease

Publication Year: 2024 Source: J Pediatr Gastroenterol Nutr PMID: 38374562 DOI: 10.1002/jpn3.12107

OBJECTIVES: Pediatric patients diagnosed with inflammatory bowel disease (IBD) are at risk of suboptimal peak bone mass attainment. This study aimed to understand rates of bone health screening adherence, describe factors associated with dual-energy X-ray absorptiometry (DXA) acquisition, and identify factors associated with abnormal DXA. METHODS: We performed a retrospective …

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