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Targeted delivery of Fc-fused PD-L1 for effective management of acute and chronic colitis
Publication Year: 2024 Source: Nat Commun PMID: 38396052 DOI: 10.1038/s41467-024-46025-0
The PD-1/PD-L1 pathway in mucosal immunity is currently actively explored and considered as a target for inflammatory bowel disease (IBD) treatment. However, systemic PD-L1 administration may cause unpredictable adverse effects due to immunosuppression. Here we show that reactive oxygen species (ROS)-responsive nanoparticles enhance the efficacy and safety of PD-L1 in …
Comprehensive assessment of nutritional and functional status of patients with ulcerative colitis and their impact on quality of life
Publication Year: 2024 Source: Indian J Gastroenterol PMID: 38396280
No Abstract
Potential Diagnostic Role of Hepcidin in Anemic Patients Affected by Inflammatory Bowel Disease: A Systematic Review
Publication Year: 2024 Source: Diagnostics (Basel) PMID: 38396414 DOI: 10.3390/diagnostics14040375
BACKGROUND: Anemia is the main extraintestinal comorbidity of Inflammatory Bowel Disease (IBD). Differentiating the type of anemia in these disorders is still a challenge. Hepcidin could be a promising biomarker to identify iron deficiency anemia (IDA), anemia of chronic disease (ACD) and the concomitant presence of both IDA and ACD. …
Recent Trends in Non-Invasive Methods of Diagnosis and Evaluation of Inflammatory Bowel Disease: A Short Review
Publication Year: 2024 Source: Int J Mol Sci PMID: 38396754 DOI: 10.3390/ijms25042077
Inflammatory bowel diseases are a conglomerate of disorders causing inflammation of the gastrointestinal tract, which have gained a significant increase in prevalence in the 21st century. As they present a challenge in the terms of diagnosis as well as treatment, IBDs can present an overwhelming impact on the individual and …
Changes in HLA-B27 Transgenic Rat Fecal Microbiota Following Tofacitinib Treatment and Ileocecal Resection Surgery: Implications for Crohn's Disease Management
Publication Year: 2024 Source: Int J Mol Sci PMID: 38396840 DOI: 10.3390/ijms25042164
The therapeutic management of Crohn's disease (CD), a chronic relapsing-remitting inflammatory bowel disease (IBD), is highly challenging. Surgical resection is sometimes a necessary procedure even though it is often associated with postoperative recurrences (PORs). Tofacitinib, an orally active small molecule Janus kinase inhibitor, is an anti-inflammatory drug meant to limit …
Pharmacological Activation of TRPC6 Channel Prevents Colitis Progression
Publication Year: 2024 Source: Int J Mol Sci PMID: 38397074 DOI: 10.3390/ijms25042401
We recently reported that transient receptor potential canonical (TRPC) 6 channel activity contributes to intracellular Zn(2+) homeostasis in the heart. Zn(2+) has also been implicated in the regulation of intestinal redox and microbial homeostasis. This study aims to investigate the role of TRPC6-mediated Zn(2+) influx in the stress resistance of …
Aryl Hydrocarbon Receptor Regulates Muc2 Production Independently of IL-22 during Colitis
Publication Year: 2024 Source: Int J Mol Sci PMID: 38397081
No Abstract
Ultrasound in Pediatric Inflammatory Bowel Disease-A Review of the State of the Art and Future Perspectives
Publication Year: 2024 Source: Children (Basel) PMID: 38397268 DOI: 10.3390/children11020156
Inflammatory bowel disease (IBD) comprises a group of relapsing, chronic diseases of the gastrointestinal tract that, in addition to adults, can affect children and adolescents. To detect relapses of inflammation, these patients require close observation, frequent follow-up, and therapeutic adjustments. While reference standard diagnostics include anamnestic factors, laboratory and stool …
Integrative Multiomics Profiling Unveils the Protective Function of Ulinastatin against Dextran Sulfate Sodium-Induced Colitis
Publication Year: 2024 Source: Antioxidants (Basel) PMID: 38397811
No Abstract
Application of SWATH Mass Spectrometry and Machine Learning in the Diagnosis of Inflammatory Bowel Disease Based on the Stool Proteome
Publication Year: 2024 Source: Biomedicines PMID: 38397935 DOI: 10.3390/biomedicines12020333
Inflammatory bowel disease (IBD) flare-ups exhibit symptoms that are similar to other diseases and conditions, making diagnosis and treatment complicated. Currently, the gold standard for diagnosing and monitoring IBD is colonoscopy and biopsy, which are invasive and uncomfortable procedures, and the fecal calprotectin test, which is not sufficiently accurate. Therefore, …
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