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Chensinin-1b Alleviates DSS-Induced Inflammatory Bowel Disease by Inducing Macrophage Switching from the M1 to the M2 Phenotype
Publication Year: 2024 Source: Biomedicines PMID: 38397947 DOI: 10.3390/biomedicines12020345
Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory disorder with an increasing prevalence worldwide. Macrophage polarization is involved in the pathogenesis of IBD. Repolarization of macrophage has thus emerged as a novel therapeutic approach for managing IBD. Chensinin-1b, derived from the skin of Rana chensinensis, is a derivative of …
microRNA-mRNA Networks Linked to Inflammation and Immune System Regulation in Inflammatory Bowel Disease
Publication Year: 2024 Source: Biomedicines PMID: 38398024 DOI: 10.3390/biomedicines12020422
The molecular processes linked to the development and progression of Crohn's disease (CD) and ulcerative colitis (UC) are not completely understood. MicroRNAs (miRNAs) regulate gene expression and are indicated as diagnostic, prognostic, and predictive biomarkers in chronic degenerative diseases. Our objectives included the identification of global miRNA expression in CD …
Therapeutic Potential for Sphingolipids in Inflammatory Bowel Disease and Colorectal Cancer
Publication Year: 2024 Source: Cancers (Basel) PMID: 38398179 DOI: 10.3390/cancers16040789
Inflammatory bowel disease (IBD), characterized by chronic inflammation in the intestinal tract, increases the risk for the development of colorectal cancer (CRC). Sphingolipids, which have been implicated in IBD and CRC, are a class of bioactive lipids that regulate cell signaling, differentiation, apoptosis, inflammation, and survival. The balance between ceramide …
Current Approaches for Monitoring of Patients with Inflammatory Bowel Diseases: A Narrative Review
Publication Year: 2024 Source: J Clin Med PMID: 38398321 DOI: 10.3390/jcm13041008
BACKGROUND: Patients with inflammatory bowel diseases (IBD) require proactive monitoring both during the active phase to evaluate therapeutic response and during the remission phase to evaluate relapse or colorectal cancer surveillance. However, monitoring may vary between patients with ulcerative colitis (UC) and Crohn's disease (CD), with distinct tools and intervals. …
Prevalence and Clinical Impact of Immune-Mediated Inflammatory Diseases in Patients with Inflammatory Bowel Disease: Results from a Large Retrospective Observational Study
Publication Year: 2024 Source: J Clin Med PMID: 38398332 DOI: 10.3390/jcm13041019
(1) Background: Inflammatory bowel diseases (IBDs) are chronic inflammatory disorders involving innate and adaptive immune responses. Despite primarily affecting the gut, recent insights highlight systemic implications, expanding our understanding beyond intestinal boundaries. (2) Methods: This retrospective multicentric study explored the association of IBD and immune-mediated inflammatory diseases (IMIDs) and the …
Incidence and Course of Joint Inflammation Associated with Inflammatory Bowel Disease in Patients Undergoing Treatment with Vedolizumab/Ustekinumab: The VEDUSTAR Study
Publication Year: 2024 Source: J Clin Med PMID: 38398390 DOI: 10.3390/jcm13041076
BACKGROUND: The role of ustekinumab (UST) and vedolizumab (VDZ) in the extraintestinal joint manifestations of inflammatory bowel disease (IBD) remain unclear, and most existing studies are retrospective. The aim of this prospective study was to analyze the incidence of new-onset joint disease or the worsening of pre-existing IBD-associated joint disease …
Inflammatory Complications in Chronic Granulomatous Disease
Publication Year: 2024 Source: J Clin Med PMID: 38398405
No Abstract
Diagnostic Value of Ileal Lesions Found during Colonoscopy with Reference to Endoscopic Indications and Findings
Publication Year: 2024 Source: J Clin Med PMID: 38398473 DOI: 10.3390/jcm13041161
No Abstract
Protective Effect of the Polyphenol Ligustroside on Colitis Induced with Dextran Sulfate Sodium in Mice
Publication Year: 2024 Source: Nutrients PMID: 38398846 DOI: 10.3390/nu16040522
Dietary polyphenols are reported to alleviate colitis by interacting with gut microbiota which plays an important role in maintaining the integrity of the intestinal barrier. As a type of dietary polyphenol, whether ligustroside (Lig) could alleviate colitis has not been explored yet. Here, we aimed to determine if supplementation of …
Therapeutic Drug Monitoring for Biologic and Small-Molecule Therapies for Inflammatory Bowel Disease
Publication Year: 2024 Source: Medicina (Kaunas) PMID: 38399538 DOI: 10.3390/medicina60020250
Background: Inflammatory bowel disease (IBD), encompassing ulcerative colitis and Crohn's disease, necessitates long-term medical therapy to manage symptoms and prevent complications. Therapeutic drug monitoring (TDM) has emerged as a strategy to optimize treatment efficacy, particularly with anti-tumour necrosis factor (anti-TNF) alpha drugs. This review explores the role of TDM for …
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