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Reviewing Recommendations for Vaccines and Health Care Maintenance in Patients With Inflammatory Bowel Disease

Publication Year: 2024 Source: Gastroenterol Hepatol (N Y) PMID: 38414913

No Abstract

Exploring Vaccination in Patients With Inflammatory Bowel Disease

Publication Year: 2024 Source: Gastroenterol Hepatol (N Y) PMID: 38414915

No Abstract

Cytokine expression in subjects with Mycobacterium avium ssp. paratuberculosis positive blood cultures and a meta-analysis of cytokine expression in Crohn's disease

Publication Year: 2024 Source: Front Cell Infect Microbiol PMID: 38415011 DOI: 10.3389/fcimb.2024.1327969

OBJECTIVES: 1) Culture Mycobacterium avium ssp. paratuberculosis (MAP)from blood, 2) assess infection persistence, 3) determine Crohn's disease (CD) cytokine expression, 4) compare CD cytokine expression to tuberculosis, and 5) perform a meta-analysis of cytokine expression in CD. METHODS: The Temple University/Abilene Christian University (TU/ACU) study had a prospective case control …

Editorial: The oral-gut axis: from ectopic colonization to within-host evolution of oral bacteria

Publication Year: 2024 Source: Front Cell Infect Microbiol PMID: 38415013

No Abstract

Metronidazole overexposure in children and its association with new-onset Crohn's disease (IBD)

Publication Year: 2024 Source: Antimicrob Steward Healthc Epidemiol PMID: 38415084 DOI: 10.1017/ash.2024.20

No Abstract

A convenient and reproducible protocol for acquisition of the hepatocyte phase for liver function-impaired patients in gadoxetic acid disodium-enhanced magnetic resonance imaging

Publication Year: 2024 Source: Quant Imaging Med Surg PMID: 38415116 DOI: 10.21037/qims-23-1147

BACKGROUND: The hepatocyte phase (HCP) in gadoxetic acid disodium (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) plays an important role in the detection and characterization of liver lesions, treatment planning, and liver function evaluation. However, the imaging protocol is complicated and time-consuming. This cross-sectional study aimed to develop a convenient and reproducible …

TLR4, IgA and EpCAM Expression in Colorectal Cancer and Their Possible Association with Microbiota as a Pathogenic Factor; An Immunohistochemical and Genetic Study

Publication Year: 2024 Source: Asian Pac J Cancer Prev PMID: 38415550 DOI: 10.31557/APJCP.2024.25.2.627

BACKGROUND: The pathogenesis of inflammatory bowel disease (IBD) and colorectal cancer (CRC) is thought to be related to immune response against gut microbiota. TLR4, IgA, and EpCAM have a role in intestinal local immune response and their altered expression related to both IBD and CRC. Lipopolysaccharide (LPS) is the main …

Sirtuin2 suppresses the polarization of regulatory T cells toward T helper 17 cells through repressing the expression of signal transducer and activator of transcription 3 in a mouse colitis model

Publication Year: 2024 Source: Immun Inflamm Dis PMID: 38415949 DOI: 10.1002/iid3.1160

INTRODUCTION: Regulatory T cells (Tregs) play an important role in inflammatory bowel diseases (IBDs) through modulating intestinal inflammation. However, the factors affecting Treg function and plasticity during IBD progression are not thoroughly disclosed. The current study aims to reveal new molecular mechanisms affecting Treg plasticity. METHODS: A mouse strain, in …

Discovery of a Highly Potent Oxysterol Receptor GPR183 Antagonist Bearing the Benzo[d]thiazole Structural Motif for the Treatment of Inflammatory Bowel Disease (IBD)

Publication Year: 2024 Source: J Med Chem PMID: 38417036 DOI: 10.1021/acs.jmedchem.3c01905

Accumulating evidence has demonstrated a critical pathological role of oxysterol receptor GPR183 in various inflammatory and autoimmune diseases, including inflammatory bowel disease (IBD). However, the currently reported GPR183 antagonists are very limited and not qualified for in vivo studies due to their inferior druglike properties. Herein, we conducted a structural …

Insurance Companies' Poor Adherence to Guidelines for Moderate-to-Severe Ulcerative Colitis/Crohn's Disease Management

Publication Year: 2024 Source: Am J Gastroenterol PMID: 38417043

No Abstract

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