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Adaptive Steroid Tapering Impedes Corticosteroid-free Remissions Compared with Forced Tapering in Clinical Trials of Ulcerative Colitis

Publication Year: 2024 Source: J Crohns Colitis PMID: 38869911

No Abstract

Temporal and spatial dynamics of Plasmodium falciparum clonal lineages in Guyana

Publication Year: 2024 Source: PLoS Pathog PMID: 38870266 DOI: 10.1371/journal.ppat.1012013

Plasmodium parasites, the causal agents of malaria, are eukaryotic organisms that obligately undergo sexual recombination within mosquitoes. In low transmission settings, parasites recombine with themselves, and the clonal lineage is propagated rather than broken up by outcrossing. We investigated whether stochastic/neutral factors drive the persistence and abundance of Plasmodium falciparum …

Discovery of autophagy-tethering compounds as potent NLRP3 degraders for IBD Immunotherapy

Publication Year: 2024 Source: Eur J Med Chem PMID: 38870831 DOI: 10.1016/j.ejmech.2024.116581

Nucleotide-binding oligomerization domain-like receptor pyrin domain containing 3 (NLRP3) constitutes an essential inflammasome sensor protein, pivotal in the orchestration of innate immunity. Given its paramount role, NLRP3 has recently emerged as an enticing therapeutic target for disorders associated with inflammation. In this study, we embarked on the design and synthesis …

Treatment strategies and biomarkers in Crohn's disease: the PROFILE trial

Publication Year: 2024 Source: Lancet Gastroenterol Hepatol PMID: 38870963

No Abstract

Treatment strategies and biomarkers in Crohn's disease: the PROFILE trial

Publication Year: 2024 Source: Lancet Gastroenterol Hepatol PMID: 38870964

No Abstract

Treatment strategies and biomarkers in Crohn's disease: the PROFILE trial

Publication Year: 2024 Source: Lancet Gastroenterol Hepatol PMID: 38870965

No Abstract

Treatment strategies and biomarkers in Crohn's disease: the PROFILE trial - Authors' reply

Publication Year: 2024 Source: Lancet Gastroenterol Hepatol PMID: 38870966

No Abstract

Treatment strategies and biomarkers in Crohn's disease: the PROFILE trial

Publication Year: 2024 Source: Lancet Gastroenterol Hepatol PMID: 38870967

No Abstract

Nonsteroidal anti-inflammatory drug-induced small bowel strictures (diaphragm disease) - an under-recognized cause of small bowel obstruction

Publication Year: 2024 Source: J Gastrointest Surg PMID: 38871074

No Abstract

Ameliorated Effects of Fucoidan on Dextran Sulfate Sodium-Induced Ulcerative Colitis and Accompanying Anxiety and Depressive Behaviors in Aged C57BL/6 Mice

Publication Year: 2024 Source: J Agric Food Chem PMID: 38871671

No Abstract

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