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Benefits of Biosimilars in the Management of Patients with Inflammatory Bowel Disease: An International Survey
Publication Year: 2024 Source: J Clin Med PMID: 38892780 DOI: 10.3390/jcm13113069
Background/Objectives: The development of biosimilar drugs has revolutionized the management of patients with inflammatory bowel diseases (IBD), significantly reducing healthcare costs. However, the impact of biosimilar availability on patient care is unknown. We conducted a survey to investigate the benefits of using biosimilars in patients with IBD. Methods: Physicians involved …
Advances in Inflammatory Bowel Disease Diagnostics: Machine Learning and Genomic Profiling Reveal Key Biomarkers for Early Detection
Publication Year: 2024 Source: Diagnostics (Basel) PMID: 38893707 DOI: 10.3390/diagnostics14111182
This study, utilizing high-throughput technologies and Machine Learning (ML), has identified gene biomarkers and molecular signatures in Inflammatory Bowel Disease (IBD). We could identify significant upregulated or downregulated genes in IBD patients by comparing gene expression levels in colonic specimens from 172 IBD patients and 22 healthy individuals using the …
Quality controlled YouTube content intervention for enhancing health literacy and health behavioural intention: A randomized controlled study
Publication Year: 2024 Source: Digit Health PMID: 38894944 DOI: 10.1177/20552076241263691
BACKGROUND: Individuals increasingly turn to the Internet for health information, with YouTube being a prominent source. However, the quality and reliability of the health information vary widely, potentially affecting health literacy and behavioural intentions. METHODS: To analyse the impact of health information quality on health literacy and behavioural intention, we …
Multiple myeloma, IL6, and risk of schizophrenia: A Mendelian randomization, transcriptome, and Bayesian colocalization study
Publication Year: 2024 Source: EJHaem PMID: 38895088
No Abstract
Circadian rhythm disruption-mediated downregulation of Bmal1 exacerbates DSS-induced colitis by impairing intestinal barrier
Publication Year: 2024 Source: Front Immunol PMID: 38895112 DOI: 10.3389/fimmu.2024.1402395
BACKGROUND: Circadian rhythm disruption (CRD) is thought to increase the risk of inflammatory bowel disease. The deletion of Bmal1, a core transcription factor, leads to a complete loss of the circadian rhythm and exacerbates the severity of dextran sodium sulfate (DSS)-induced colitis in mice. However, the underlying mechanisms by which …
Role of long non-coding RNA in inflammatory bowel disease
Publication Year: 2024 Source: Front Immunol PMID: 38895124 DOI: 10.3389/fimmu.2024.1406538
Inflammatory bowel disease (IBD) is a group of recurrent chronic inflammatory diseases, including Crohn's disease (CD) and ulcerative colitis (UC). Although IBD has been extensively studied for decades, its cause and pathogenesis remain unclear. Existing research suggests that IBD may be the result of an interaction between genetic factors, environmental …
Distinct metabolomic and lipidomic profiles in serum samples of patients with primary sclerosing cholangitis
Publication Year: 2024 Source: Front Med (Lausanne) PMID: 38895187 DOI: 10.3389/fmed.2024.1334865
INTODUCTION: Identification of specific metabolome and lipidome profile of patients with primary sclerosing cholangitis (PSC) is crucial for diagnosis, targeted personalized therapy, and more accurate risk stratification. METHODS: Nuclear magnetic resonance (NMR) spectroscopy revealed an altered metabolome and lipidome of 33 patients with PSC [24 patients with inflammatory bowel disease …
Ferroptosis: a new mechanism of traditional Chinese medicine for treating ulcerative colitis
Publication Year: 2024 Source: Front Pharmacol PMID: 38895617
No Abstract
Intestinal retinol saturase is implicated in the development of obesity and epithelial homeostasis upon injury
Publication Year: 2024 Source: Am J Physiol Endocrinol Metab PMID: 38895981
No Abstract
First Report on Chronic Granulomatous Disease from Nepal and a Review of CYBC1 Deficiency
Publication Year: 2024 Source: J Clin Immunol PMID: 38896305 DOI: 10.1007/s10875-024-01752-3
Chronic granulomatous disease (CGD) primarily results from inherited defects in components of the nicotinamide adenine dinucleotide phosphate oxidase enzyme complex. These include gene defects in cytochrome B-245/558 subunit alpha/beta and neutrophil cytosolic factors 1, 2, and 4. Recently, homozygous loss-of-function variants in cytochrome B-245 chaperone 1 gene (CYBC1) have been …
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