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Mapping Crohn's Disease Pathogenesis with Mycobacterium paratuberculosis: A Hijacking by a Stealth Pathogen

Publication Year: 2024 Source: Dig Dis Sci PMID: 38896362

No Abstract

G Protein-Coupled Estrogen Receptor-Mediated Anti-Inflammatory and Mucosal Healing Activity of a Trimethylpyridinol Analogue in Inflammatory Bowel Disease

Publication Year: 2024 Source: J Med Chem PMID: 38896548 DOI: 10.1021/acs.jmedchem.3c02458

Inflammatory bowel disease (IBD) is characterized by abnormal immune responses, including elevated proinflammatory cytokines, such as tumor necrosis factor-alpha (TNFalpha) and interleukin-6 (IL-6) in the gastrointestinal (GI) tract. This study presents the synthesis and anti-inflammatory evaluation of 2,4,5-trimethylpyridin-3-ol analogues, which exhibit dual inhibition of TNFalpha- and IL-6-induced inflammation. Analysis using …

COVID-19 IN INFLAMMATORY BOWEL DISEASE: SHOULD WE BE MORE CAREFUL WITH THE USE OF SALICYLATES?

Publication Year: 2024 Source: Arq Gastroenterol PMID: 38896575 DOI: 10.1590/S0004-2803.24612023-155

BACKGROUNDS: Fortunately, much has been studied about COVID-19 in patients with inflammatory bowel diseases (IBD). Evidence suggests that these patients do not appear to be at increased risk of severe COVID-19. However, there are still some uncertainties regarding the clinical manifestations of COVID-19 in patients with immune-mediated diseases. OBJECTIVE: This …

The mediating effect of blood biomarkers in the associations between inflammatory bowel disease and incident psychiatric disorders: a prospective cohort study

Publication Year: 2024 Source: Int J Surg PMID: 38896866 DOI: 10.1097/JS9.0000000000001831

BACKGROUND: Despite the growing evidence of an association between inflammatory bowel disease (IBD) and psychiatric disorders, there has been limited research exploring the underlying mediating role of blood biomarkers on the gut-brain axis. This study aimed to examine the association between IBD and the risk of incident psychiatric disorders and …

Serum metabolomics reveals the effectiveness of human placental mesenchymal stem cell therapy for Crohn's disease

Publication Year: 2024 Source: Talanta PMID: 38897006

No Abstract

Anti-PD-L1 antibody retains antitumour effects while mitigating immunotherapy-related colitis in bladder cancer-bearing mice after CT-mediated intratumoral delivery

Publication Year: 2024 Source: Int Immunopharmacol PMID: 38897122

No Abstract

Uptake, safety and effectiveness of inactivated influenza vaccine in inflammatory bowel disease: a UK-wide study

Publication Year: 2024 Source: BMJ Open Gastroenterol PMID: 38897611 DOI: 10.1136/bmjgast-2024-001370

OBJECTIVE: To investigate (1) the UK-wide inactivated influenza vaccine (IIV) uptake in adults with inflammatory bowel disease (IBD), (2) the association between vaccination against influenza and IBD flare and (3) the effectiveness of IIV in preventing morbidity and mortality. DESIGN: Data for adults with IBD diagnosed before the 1 September …

Indications, modalities, and outcomes of surgery for ulcerative colitis in 2024

Publication Year: 2024 Source: J Visc Surg PMID: 38897710

No Abstract

Factors correlated with transmural healing in patients with Crohn's disease in long-term clinical remission on anti-TNF medication

Publication Year: 2024 Source: Dig Liver Dis PMID: 38897858

No Abstract

Stem-like T cells are associated with the pathogenesis of ulcerative colitis in humans

Publication Year: 2024 Source: Nat Immunol PMID: 38898157

No Abstract

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