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Enhancing gut barrier integrity: Upregulation of tight junction proteins by chitosan oligosaccharide through the ERK1/2 signaling pathway
Publication Year: 2024 Source: Nutrition PMID: 38663127
No Abstract
Multimodal single-cell analyses reveal mechanisms of perianal fistula in diverse patients with Crohn's disease
Publication Year: 2024 Source: Med PMID: 38663404
No Abstract
The atypical IκB family member Bcl3 determines differentiation and fate of intestinal RORγt(+) regulatory T-cell subsets
Publication Year: 2024 Source: Mucosal Immunol PMID: 38663461
No Abstract
Bazedoxifene attenuates dextran sodium sulfate-induced colitis in mice through gut microbiota modulation and inhibition of STAT3 and NF-κB pathways
Publication Year: 2024 Source: Eur J Pharmacol PMID: 38663540 DOI: 10.1016/j.ejphar.2024.176611
Inflammatory bowel disease (IBD) is a chronic and relapsing inflammatory disorder of the gastrointestinal tract for which treatment options remain limited. In this study, we used a dual-luciferase-based screening of an FDA-approved drug library, identifying Bazedoxifene (BZA) as an inhibitor of the NF-kappaB pathway. We further investigated its therapeutic effects …
Nitazoxanide protects against experimental ulcerative colitis through improving intestinal barrier and inhibiting inflammation
Publication Year: 2024 Source: Chem Biol Interact PMID: 38663798
No Abstract
Bergapten enhances mitophagy to regulate intestinal barrier and Th17/Treg balance in mice with Crohn's disease-like colitis via PPARγ/NF-κB signaling pathway
Publication Year: 2024 Source: Naunyn Schmiedebergs Arch Pharmacol PMID: 38664245
No Abstract
Placental Histopathological Lesions and Adverse Neonatal Outcomes in Patients with Inflammatory Bowel Diseases- A retrospective Cohort Study
Publication Year: 2024 Source: Reprod Sci PMID: 38664358 DOI: 10.1007/s43032-024-01571-2
Inflammatory bowel diseases (IBD) are significantly associated with adverse pregnancy and neonatal outcomes, though the pathomechanism is yet unknown. To investigate the relationship between IBD and adverse pregnancy outcomes by comparing neonatal outcomes and placental histopathology in two matched groups of patients with and without IBD. In this retrospective study, …
Biological characteristics of molecular subtypes of ulcerative colitis characterized by ferroptosis and neutrophil infiltration
Publication Year: 2024 Source: Sci Rep PMID: 38664443
No Abstract
Pouchitis: pathophysiology and management
Publication Year: 2024 Source: Nat Rev Gastroenterol Hepatol PMID: 38664536
No Abstract
New insights into the interactions between the gut microbiota and the inflammatory response to ulcerative colitis in a mouse model of dextran sodium sulfate and possible mechanisms of action for treatment with PE&AFWE
Publication Year: 2024 Source: Animal Model Exp Med PMID: 38664929 DOI: 10.1002/ame2.12405
BACKGROUND: Inflammatory bowel disease (IBD), comprising Crohn's disease (CD) and ulcerative colitis (UC), is a heterogeneous state of chronic intestinal inflammation. Intestinal innate immunity, including innate immune cells, defends against pathogens and excessive entry of gut microbiota, while preserving immune tolerance to resident intestinal microbiota, and may be characterized by …
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