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C-reactive Protein: An Inflammatory Biomarker and a Predictor of Neurodegenerative Disease in Patients With Inflammatory Bowel Disease?
Publication Year: 2024 Source: Cureus PMID: 38665135 DOI: 10.7759/cureus.59009
Inflammatory bowel disease (IBD) refers to two chronic conditions of the digestive tract: ulcerative colitis (UC) and Crohn's disease (CD), representing a progressive inflammatory process that mainly occurs in the gut, with frequent extra-intestinal manifestations. Even if remission is periodically obtained for some patients, the histological activity and digestive symptoms …
Evaluation of emergency hospital admissions for inflammatory bowel disease as a possible marker of quality of care of British IBD inflammatory bowel disease units
Publication Year: 2024 Source: Frontline Gastroenterol PMID: 38665788 DOI: 10.1136/flgastro-2023-102577
BACKGROUND: Key performance indicators (KPIs) are required to facilitate quality improvement for inflammatory bowel disease (IBD). Emergency admissions for IBD may represent a possible KPI. METHODS: IBD emergency admissions for 2018-2019 from Hospital Episodes Statistics for England were compared per population and per IBD cases with patient-reported quality of care …
Maintaining remission in Crohn's disease post surgery: what can we learn from Cochrane?
Publication Year: 2024 Source: Frontline Gastroenterol PMID: 38665790 DOI: 10.1136/flgastro-2023-102559
Surgery is a vital pillar in the management of Crohn's disease and medical options for prevention of recurrence after surgery are a key consideration. The main classes of effective induction therapies have very different efficacy data for maintenance and this is more pronounced in the postsurgical setting. In this review …
Role of diet in prevention versus treatment of Crohn's disease and ulcerative colitis
Publication Year: 2024 Source: Frontline Gastroenterol PMID: 38665795 DOI: 10.1136/flgastro-2023-102417
Diet is a modifiable risk factor for disease course and data over the past decade have emerged to indicate its role in Crohn's disease (CD) and ulcerative colitis (UC). However, literature is riddled with misinterpretation of data, often leading to unexpected or conflicting results. The key understanding is that causative …
Gastroenterology trainee experience, confidence and satisfaction in nutrition training: a cross-sectional survey in the UK
Publication Year: 2024 Source: Frontline Gastroenterol PMID: 38665797
No Abstract
Bacterial membrane vesicles in the pathogenesis and treatment of inflammatory bowel disease
Publication Year: 2024 Source: Gut Microbes PMID: 38666762 DOI: 10.1080/19490976.2024.2341670
Inflammatory bowel disease (IBD) is a chronic and debilitating condition of relapsing and remitting inflammation in the gastrointestinal tract. Conventional therapeutic approaches for IBD have shown limited efficacy and detrimental side effects, leading to the quest for novel and effective treatment options for the disease. Bacterial membrane vesicles (MVs) are …
Perioperative Considerations for the Surgical Treatment of Crohn's Disease with Discussion on Surgical Antibiotics Practices and Impact on the Gut Microbiome
Publication Year: 2024 Source: Antibiotics (Basel) PMID: 38666993 DOI: 10.3390/antibiotics13040317
Crohn's disease, a chronic inflammatory process of the gastrointestinal tract defined by flares and periods of remission, is increasing in incidence. Despite advances in multimodal medical therapy, disease progression often necessitates multiple operations with high morbidity. The inability to treat Crohn's disease successfully is likely in part because the etiopathogenesis …
Inhibition of Immunoproteasome Attenuates NLRP3 Inflammasome Response by Regulating E3 Ubiquitin Ligase TRIM31
Publication Year: 2024 Source: Cells PMID: 38667290 DOI: 10.3390/cells13080675
Excessive secretion of pro-inflammatory cytokines leads to the disruption of intestinal barrier in inflammatory bowel disease (IBD). The inflammatory cytokine tumor necrosis factor alpha (TNFalpha) induces the assembly of the NLRP3 inflammasome, resulting in the augmented secretion of inflammatory cytokines implicated in the pathogenesis of inflammatory bowel disease (IBD). TNFalpha …
Recently Updated Role of Chitinase 3-like 1 on Various Cell Types as a Major Influencer of Chronic Inflammation
Publication Year: 2024 Source: Cells PMID: 38667293
No Abstract
Pregnane X Receptor Signaling Pathway and Vitamin K: Molecular Mechanisms and Clinical Relevance in Human Health
Publication Year: 2024 Source: Cells PMID: 38667296 DOI: 10.3390/cells13080681
This review explores the likely clinical impact of Pregnane X Receptor (PXR) activation by vitamin K on human health. PXR, initially recognized as a master regulator of xenobiotic metabolism in liver, emerges as a key regulator influencing intestinal homeostasis, inflammation, oxidative stress, and autophagy. The activation of PXR by vitamin …
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