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Apoptosis in the intestinal mucosa of patients with inflammatory bowel disease: evidence of altered expression of FasL and perforin cytotoxic pathways
Publication Year: 2005 Source: Int J Colorectal Dis PMID: 15503066 DOI: 10.1007/s00384-004-0639-8
mdr1a-deficient mice lack P-glycoprotein and spontaneously develop colitis with age. Helicobacter spp. are gram-negative organisms that have been associated with colitis in certain mouse strains, but Helicobacter spp. have been excluded as contributing to the spontaneous colitis that develops in mdr1a-/- mice. We wished to determine whether infection with either …
Regulation of intestinal epithelial function: a link between opportunities for macromolecular drug delivery and inflammatory bowel disease
Publication Year: 2005 Source: Adv Drug Deliv Rev PMID: 15555739 DOI: 10.1016/j.addr.2004.08.005
Much of the morbidity associated with inflammatory bowel disease (IBD) and infection is caused by disordered gastrointestinal motor and secretory functions. Given that intestinal smooth muscle tone and epithelial cell secretion are regulated by the enteric nervous system (ENS), it is quite likely that inflammation-induced changes in the enteric neural …
New oral delivery systems for treatment of inflammatory bowel disease
Publication Year: 2005 Source: Adv Drug Deliv Rev PMID: 15555741 DOI: 10.1016/j.addr.2004.08.011
Inflammatory bowel diseases (IBD) are chronic conditions of unknown etiology. Current therapy mitigates the severity of acute bouts of mucosal inflammation but an eradication therapy is lacking. Growing incidence of IBD is associated with social development. Epidemiology suggests a relationship between the establishment of the individual gut flora and the …
Topical delivery of therapeutic agents in the treatment of inflammatory bowel disease
Publication Year: 2005 Source: Adv Drug Deliv Rev PMID: 15555742 DOI: 10.1016/j.addr.2004.08.007
BACKGROUND: Persistent enterocutaneous fistulae are associated with high morbidity and mortality and are surgically challenging to repair. Anti-TNF alpha antibody (Infliximab) promotes healing of fistulae associated with active inflammatory bowel disease (IBD). We report three patients with persistent fistulae, not associated with IBD that healed following single infusion of infliximab. …
Association between mutations in the CARD15/NOD2 gene and colorectal cancer in a Greek population
Publication Year: 2005 Source: Int J Cancer PMID: 15578724 DOI: 10.1002/ijc.20747
Comment in Eur J Nucl Med Mol Imaging. 2002 Aug;29(8):1098. Scintigraphy with technetium-99m labelled white blood cells (WBCs) is routinely used in our hospital for the assessment of inflammatory bowel disease (IBD). The main disadvantages of this diagnostic tool are its time-consuming nature and the handling of blood itself. 99mTc-LeukoScan …
Case-control single-marker and haplotypic association analysis of pedigree data
Publication Year: 2005 Source: Genet Epidemiol PMID: 15578751 DOI: 10.1002/gepi.20051
The intestinal epithelium performs a multitude of tasks related to digestion and homeostasis. As a consequence of ingestion, this tissue must also participate in activities associated with protecting the body from potential pathogenic agents and toxic materials. To efficiently perform tasks associated with digestion and these protective functions, the intestinal …
CD40 antisense oligonucleotide inhibition of trinitrobenzene sulphonic acid induced rat colitis
Publication Year: 2005 Source: Gut PMID: 15591506 DOI: 10.1136/gut.2003.029587
Comment in Gut. 2005 Feb;54(2):308; author reply 309. Gut. 2005 Mar;54(3):439-40. BACKGROUND AND AIMS: Elicitation of an innate immune response to bacterial products is mediated through pattern recognition receptors (PRRs) such as the toll-like receptors (TLRs) and the NODs. The recently characterised Asp299Gly polymorphism in the lipopolysaccharide (LPS) receptor TLR4 …
CD4+CD45RBHi T cell transfer induced colitis in mice is accompanied by osteopenia which is treatable with recombinant human osteoprotegerin
Publication Year: 2005 Source: Gut PMID: 15591508 DOI: 10.1136/gut.2003.035113
TL1A is a novel TNF-like factor that acts as a costimulator of IFN-gamma secretion through binding to the death domain-containing receptor, DR3. The aim of this study was to test the hypothesis that TL1A may play an important role in inflammatory bowel disease (IBD) by functioning as a Th1-polarizing cytokine. …
PSC-IBD: a unique form of inflammatory bowel disease associated with primary sclerosing cholangitis
Publication Year: 2005 Source: Gut PMID: 15591511 DOI: 10.1136/gut.2004.046615
Background: An observational study was conducted at eight university and four district hospitals in eight countries collaborating in clinical and epidemiological research in inflammatory bowel disease (IBD) to compare European health care facilities and to define current "best practice" with regard to IBD. Methods: The approach used in this multi-national …
Calcium and 1 alpha,25-dihydroxyvitamin D3 target the TNF-alpha pathway to suppress experimental inflammatory bowel disease
Publication Year: 2005 Source: Eur J Immunol PMID: 15593122 DOI: 10.1002/eji.200425491
The purpose of this study was to conduct a survey examining the impact of inflammatory bowel disease (IBD) on patients' and their caregivers' daily activities. Questionnaires were distributed to patients registered in the APDI (Portuguese Association for IBD) database and their respective caregivers in 2007. Of 422 patient respondents, 251 …
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