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The future of coloproctology in the UK: the trainees view
Publication Year: 2005 Source: Colorectal Dis PMID: 15606591 DOI: 10.1111/j.1463-1318.2004.00731.x
Azathioprine is an immunosuppressive drug used in the treatment of inflammatory bowel disease. It is a prodrug that is hydrolysed to 6-mercaptopurine, which represents the active form. Azathioprine is also used in the treatment of leukaemia in children and in organ transplantation. Azathioprine treatment is associated with adverse effects such …
Enhanced interleukin-18 levels in the peripheral blood of children with coeliac disease
Publication Year: 2005 Source: Clin Exp Immunol PMID: 15606624 DOI: 10.1111/j.1365-2249.2005.02661.x
The glycoprotein lactoferrin is found in many body fluids but also in the granules of neutrophilic granulocytes. Fecal lactoferrin levels increase quickly with the influx of leukocytes into the intestinal lumen during inflammation. This biomarker has recently been shown to be a sensitive and specific marker of disease activity in …
Alanylglutamine dipeptide and growth hormone maintain PepT1-mediated transport in oxidatively stressed Caco-2 cells
Publication Year: 2005 Source: J Nutr PMID: 15623827 DOI: 10.1093/jn/135.1.19
Although the cause of Crohn's disease remains unknown considerable progress has been made in recent years to unravel the pathogenesis of the inflammatory processes seen in chronic idiopathic inflammatory bowel diseases (IBD). Th-1 lymphocytes seem to orchestrate the inflammation through the production of pro-inflammatory cytokines such as IFN-gamma, IL-1beta and …
Cytokine mRNA quantification in histologically normal canine duodenal mucosa by real-time RT-PCR
Publication Year: 2005 Source: Vet Immunol Immunopathol PMID: 15626466 DOI: 10.1016/j.vetimm.2004.08.020
BACKGROUND: Inflammatory bowel disease (IBD)-associated anaemia usually responds to intravenous iron. If not, additive treatment with erythropoietin has been proposed. The objective of the present retrospective study was to evaluate the effectiveness of treatment with iron sucrose alone. METHODS: Sixty-one patients with IBD and anaemia (average haemoglobin 97 g/L) were …
Quantification of immune cell populations in the lamina propria of equine jejunal biopsy specimens
Publication Year: 2005 Source: J Comp Pathol PMID: 15629483 DOI: 10.1016/j.jcpa.2004.06.002
Polyamines and their acetylated derivatives are a prerequisite for cellular metabolism and considered to be essential for proliferation and differentiation of the rapidly renewing intestinal mucosa. However, their role during mucosal inflammation is less clear. Polyamine concentrations were determined in isolated colonic epithelial cells (CECs) from endoscopic biopsies from 26 …
5-aminosalicylic acid is an attractive candidate agent for chemoprevention of colon cancer in patients with inflammatory bowel disease
Publication Year: 2005 Source: World J Gastroenterol PMID: 15637733 DOI: 10.3748/wjg.v11.i3.309
Inflammatory bowel disease (IBD) is a generic term that refers to Crohn's disease and chronic ulcerative colitis (UC). The CD and UC are considered to be distinct forms of IBD; but there is a subgroup of CD with a UC-like presentation. The genetic factors play a significant role in IBD. …
Association of Fas-670 gene polymorphism with inflammatory bowel disease in Chinese patients
Publication Year: 2005 Source: World J Gastroenterol PMID: 15637757 DOI: 10.3748/wjg.v11.i3.415
Crohn's disease (CD) and ulcerative colitis (UC) have a strong genetic component, contributing to a patient's susceptibility for inflammatory bowl disease (IBD). Linkage analysis has detected an IBD susceptibility locus in a region on chromosome 7q that encompasses the p47 (NCF1) gene and p47 (PsiNCF1) pseudogenes. Involvement of the NCF1 …
Characterization of genotype-phenotype relationships and stratification by the CARD15 variant genotype for inflammatory bowel disease susceptibility loci using multiple short tandem repeat genetic markers
Publication Year: 2005 Source: Hum Mutat PMID: 15643611 DOI: 10.1002/humu.20129
BACKGROUND: Interleukin-6 (IL-6) has multiple immunological effects on a wide variety of cells and tissues. The expression of IL-6 and IL-6 receptor (IL-6R) may be important to the pathogenesis of inflammatory bowel disease (IBD). METHODS: In the present study, we examined whether mucosal IL-6 and soluble IL-6R were associated with …
Children with early-onset inflammatory bowel disease (IBD): analysis of a pediatric IBD consortium registry
Publication Year: 2005 Source: J Pediatr PMID: 15644819 DOI: 10.1016/j.jpeds.2004.08.043
Republished from Gastroenterol Clin North Am. 2009 Dec;38(4):669-89. This article describes the cancer risks of commonly used inflammatory bowel disease (IBD) medications, with an emphasis on hematologic malignancy risks. The increasing use of immunosuppressant therapies in the treatment of IBD has raised this question to an even greater importance. Studies …
Endoscopy in inflammatory bowel disease: indications, surveillance, and use in clinical practice
Publication Year: 2005 Source: Clin Gastroenterol Hepatol PMID: 15645399 DOI: 10.1016/s1542-3565(04)00441-0
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