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New cytokine therapeutics for inflammatory bowel disease
Publication Year: 2004 Source: Cytokine PMID: 15588691 DOI: 10.1016/j.cyto.2004.07.012
Mapping quantitative trait loci in plants is usually conducted using a population derived from a cross between two inbred lines. The power of such QTL detection and the parameter estimates depend largely on the choice of the two parental lines. Thus, the QTL detected in such populations represent only a …
Is it time to re-classify Crohn's disease?
Publication Year: 2004 Source: Best Pract Res Clin Gastroenterol PMID: 15588801 DOI: 10.1016/j.bpg.2004.06.018
DNA microarray profiling of CD4(+) and CD8(+) cells from non-treated relapsing and remitting multiple sclerosis (MS) patients determined that the cytoplasmic binding partner of fragile X protein (CYFIP2, also called PIR121) was increased significantly compared to healthy controls. Western analysis confirmed that CYFIP2 protein was increased approximately fourfold in CD4(+) …
Low levels of antibodies against E. coli and mycobacterial 65kDa heat shock proteins in patients with inflammatory bowel disease
Publication Year: 2004 Source: Inflamm Res PMID: 15597150 DOI: 10.1007/s00011-004-1296-7
BACKGROUND: A loss of intestinal glycosaminoglycans (GAGs) has been shown in inflammatory bowel diseases (IBD). Since GAGs are involved in the regulation of renal protein filtration and GAGs disruption is associated with anionic proteinuria, we examined whether changes in the selectivity of renal protein filtration occur in IBD. METHODS: From …
Vanilloid receptor 1 antagonists attenuate disease severity in dextran sulphate sodium-induced colitis in mice
Publication Year: 2004 Source: Neurogastroenterol Motil PMID: 15601431 DOI: 10.1111/j.1365-2982.2004.00549.x
For diseases with complex genetic etiology, more than one susceptibility gene may exist in a single chromosomal region. Extending the work of Liang et al. ([2001] Hum. Hered. 51:64-78), we developed a method for simultaneous localization of two susceptibility genes in one region. We derived an expression for expected allele …
Liver abscess in inflammatory bowel disease: report of two cases and review of the literature
Publication Year: 2004 Source: J Gastroenterol Hepatol PMID: 15610305 DOI: 10.1111/j.1440-1746.2004.03368.x
BACKGROUND: Obesity is a significant public health threat to children in the United States. The aims were to: 1) Determine the prevalence of obesity in a multicenter cohort of children with inflammatory bowel disease (IBD); 2) Evaluate whether overweight and obese status is associated with patient demographics or disease characteristics. …
Infrequency of colonization with Oxalobacter formigenes in inflammatory bowel disease: possible role in renal stone formation
Publication Year: 2004 Source: J Gastroenterol Hepatol PMID: 15610315 DOI: 10.1111/j.1440-1746.2004.03510.x
Comment in Inflamm Bowel Dis. 2013 Jan;19(1):E8-E10. BACKGROUND: Intestinal bacteria have been implicated in the etiology of the common inflammatory bowel diseases (IBD) ulcerative colitis and Crohn's disease. Because delivery by cesarean section disturbs the normal bacterial colonization of the newborn's intestine, we determined the risk of IBD according to …
Role and regulation of intestinal epithelial heat shock proteins in health and disease
Publication Year: 2004 Source: Chin J Dig Dis PMID: 15612656 DOI: 10.1111/j.1443-9573.2004.00154.x
PURPOSE: The common hepatic duct is usually divided during the early stage of pancreaticoduodenectomy. However, abrupt, complete, and prolonged closure of the proximal common duct stump can cause liver damage in the course of this long operation, resulting in postoperative liver dysfunction and associated complications. Here, we investigate this phenomenon …
Predictors of disease-related concerns and other aspects of health-related quality of life in outpatients with inflammatory bowel disease
Publication Year: 2004 Source: Eur J Gastroenterol Hepatol PMID: 15618832 DOI: 10.1097/00042737-200412000-00007
Inflammatory bowel diseases (IBD) are diagnoses that can be easily overlooked clinically. The aim of this study was to investigate if CT is able to make a contribution to the identification of previously unsuspected cases of IBD. We retrospectively identified cases in which the possibility of an IBD was raised …
Therapeutic drug monitoring of thiopurine drugs in patients with inflammatory bowel disease or autoimmune hepatitis
Publication Year: 2004 Source: Eur J Gastroenterol Hepatol PMID: 15618853 DOI: 10.1097/00042737-200412000-00028
MHC class I chain gene A (MICA) is a non-classical Class I gene which is expressed on the surface of epithelia without beta 2-microglobulin. The gene is found in the major histocompatibility complex (MHC) in tight linkage disequilibrium with human leucocyte antigen-B (HLA-B). Its precise function is unknown, but it …
Immunomodulatory therapy for inflammatory bowel disease
Publication Year: 2004 Source: J Gastroenterol PMID: 15622475 DOI: 10.1007/s00535-004-1461-3
The purported association between alexithymia and inflammatory bowel disease (IBD) was investigated in a group of 112 IBD patients (89 with ulcerative colitis and 23 with Crohn's disease) using the well-validated 20-Item Toronto Alexithymia Scale. Alexithymia was assessed also in a group of 112 normal subjects matched for gender, age, …
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