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Indeterminate colitis
Publication Year: 2004 Source: J Clin Pathol PMID: 15563659 DOI: 10.1136/jcp.2003.015214
Efficient haplotyping in pedigrees is important for the fine mapping of quantitative trait locus (QTL) or complex disease genes. To reconstruct haplotypes efficiently for a large pedigree with a large number of linked loci, two algorithms based on conditional probabilities and likelihood computations are presented. The first algorithm (the conditional …
Use of complementary and alternative medicines by children and adolescents with inflammatory bowel disease
Publication Year: 2004 Source: J Paediatr Child Health PMID: 15569284 DOI: 10.1111/j.1440-1754.2004.00510.x
Intestinal intraepithelial lymphocytes (IEL) bearing TCRgammadelta represent a major T cell population in the murine intestine. However, the role of gammadelta IEL in inflammatory bowel diseases (IBD) remains controversial. In this study, we show that gammadelta IEL is an important protective T cell population against IBD. gammadelta T cell-deficient (Cdelta(-/-)) …
Efficacy of conventional immunosuppressive drugs in IBD
Publication Year: 2004 Source: Dig Liver Dis PMID: 15571009 DOI: 10.1016/j.dld.2004.06.014
We describe two male patients with ulcerative colitis and refractory pyoderma gangrenosum including periorbital phlegmona in one case. Both patients were successfully managed with low dose oral tacrolimus (0.1 mg/kg bodyweight per day). Serum trough levels were closely monitored and maintained between 4 and 6 ng/mL. A rapid response was …
Knowledge, quality of life, and use of complementary and alternative medicine and therapies in inflammatory bowel disease: a comparison of Chinese and Caucasian patients
Publication Year: 2004 Source: Dig Dis Sci PMID: 15573925 DOI: 10.1023/b:ddas.0000043384.26092.f4
Infectious gastroenteritis may be one of the important factors in the development of irritable bowel syndrome (IBS), with affected individuals often categorized as having post-infectious IBS (PI-IBS), and is linked to the onset of symptoms in approximately 10-20% of patients diagnosed with IBS. Intestinal mucosal infiltration of T cells and …
Prophylactic administration of topical glutamine enhances the capability of the rat colon to resist inflammatory damage
Publication Year: 2004 Source: Dig Dis Sci PMID: 15573931 DOI: 10.1023/b:ddas.0000043390.12150.8b
Since the aetiopathogenesis of primary sclerosing cholangitis (PSC) in humans remains undefined, investigators have studied a variety of animal models to gain insights into immunopathogenetic mechanisms associated with obliterative fibrous cholangitis of intra- and extra-hepatic bile ducts. To date, no animal model has been developed that exhibits all of the …
Stress increases susceptibility to oxidative/nitrosative mucosal damage in an experimental model of colitis in rats
Publication Year: 2004 Source: Dig Dis Sci PMID: 15573932 DOI: 10.1023/b:ddas.0000043391.64073.e4
BACKGROUND: Inflammatory bowel disease is associated with an increased incidence of thromboembolic complications. The aim of this study was to investigate the role of the soluble CD40 ligand (sCD40L), which displays prothrombotic properties, in patients with ulcerative colitis (UC) and Crohn's disease (CD) in comparison with inflammatory and healthy controls. …
Quantitative trait loci (QTL) detection in multicross inbred designs: recovering QTL identical-by-descent status information from marker data
Publication Year: 2004 Source: Genetics PMID: 15579720 DOI: 10.1534/genetics.104.028993
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Scientists explore pathogenesis of IBD
Publication Year: 2004 Source: JAMA PMID: 15585721 DOI: 10.1001/jama.292.22.2708
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Vitamin D status, 1,25-dihydroxyvitamin D3, and the immune system
Publication Year: 2004 Source: Am J Clin Nutr PMID: 15585793 DOI: 10.1093/ajcn/80.6.1717S
Comment in Gut. 2004 Jun;53(6):780-2. BACKGROUND: Several placebo controlled studies have demonstrated the efficacy of infliximab in inflammatory bowel disease (IBD) but the potential toxicity of this new biological compound has been less studied. AIM: To assess the use of infliximab in IBD in a population based cohort, with special …
Engineered osteochondral grafts using biphasic composite solid free-form fabricated scaffolds
Publication Year: 2004 Source: Tissue Eng PMID: 15588398 DOI: 10.1089/ten.2004.10.1376
For targeting local and systemic inflammatory processes in inflammatory bowel disease (IBD) therapeutic agents of first choice (e.g. aminosalicylates, corticosteroids) have been developed in special galenic forms to accomplish the topical delivery of the active compounds to the terminal ileum (Crohn's disease) and/or the colon (Crohn's disease and ulcerative colitis). …
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