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Changes in enteric neural circuitry and smooth muscle in the inflamed and infected gut
Publication Year: 2004 Source: Neurogastroenterol Motil PMID: 15066019 DOI: 10.1111/j.1743-3150.2004.00489.x
Drugs can have adverse effects on any part of the gastrointestinal (GI) tract from mouth to colon. It is essential that a detailed and accurate drug history is taken in patients presenting with GI complaints. Many drug-induced effects will regress or heal on cessation of treatment. NSAIDs are usually associated …
High incidence of anergy in inflammatory bowel disease patients limits the usefulness of PPD screening before infliximab therapy
Publication Year: 2004 Source: Clin Gastroenterol Hepatol PMID: 15067625 DOI: 10.1016/s1542-3565(04)00060-6
Anti-tumor necrosis factor alpha (TNF-α) medications are a class of biologics employed in the treatment of patients with inflammatory bowel disease (IBD). Adalimumab is the first fully human monoclonal immunoglobulin directed against TNF-α, which binds with high affinity and specificity to membrane and soluble TNF. Adalimumab administered subcutaneously has demonstrated …
Innate immunity and toll-like receptors: clinical implications of basic science research
Publication Year: 2004 Source: J Pediatr PMID: 15069387 DOI: 10.1016/j.jpeds.2004.01.057
The increasing number of peptide and protein drugs being investigated demands the development of dosage forms which exhibit site-specific release. Delivery of drugs into systemic circulation through colonic absorption represents a novel mode of introducing peptide and protein drug molecules and drugs that are poorly absorbed from the upper gastrointestinal …
Screening for dysplasia and TP53 mutations in closed rectal stumps of patients with ulcerative colitis or Crohn disease
Publication Year: 2004 Source: Scand J Gastroenterol PMID: 15074392 DOI: 10.1080/00365520310008368
Strong epidemiological evidence for a genetic contribution to pathogenesis in inflammatory bowel disease (IBD) has stimulated efforts to identify susceptibility genes for both of its major clinical forms, Crohn's disease and ulcerative colitis. Genome scans for linkage have indicated multiple regions of interest, but replication of these has been limited. …
Bone mineral assessment by dual energy X-ray absorptiometry in children with inflammatory bowel disease: evaluation by age or bone area
Publication Year: 2004 Source: J Pediatr Gastroenterol Nutr PMID: 15076625 DOI: 10.1097/00005176-200403000-00008
Retraction in J Biol Chem. 2020 Jan 3;295(1):293. Microsomal prostaglandin E synthase-1 (mPGES-1) catalyzes the conversion of cyclooxygenase-derived prostaglandin (PG) H(2) to PGE(2). Increased amounts of mPGES-1 were detected in inflamed intestinal mucosa from patients with inflammatory bowel disease (IBD). Treatment with tumor necrosis factor (TNF)-alpha stimulated mPGES-1 transcription in …
The incidence of pediatric inflammatory bowel disease in the Netherlands: 1999-2001
Publication Year: 2004 Source: J Pediatr Gastroenterol Nutr PMID: 15076631 DOI: 10.1097/00005176-200403000-00014
Inflammatory bowel disease (IBD) is considered to be the most common cause of vomiting and diarrhoea in dogs, and the German shepherd dog (GSD) is particularly susceptible. The exact aetiology of IBD is unknown, however associations have been identified between specific single-nucleotide polymorphisms (SNPs) in Toll-like receptors (TLRs) and human …
Comparing linkage disequilibrium-based methods for fine mapping quantitative trait loci
Publication Year: 2004 Source: Genetics PMID: 15082569 DOI: 10.1534/genetics.166.3.1561
Comment in Gastroenterology. 2001 Aug;121(2):504-6. BACKGROUND & AIMS: A high prevalence of osteoporosis is reported in inflammatory bowel disease (IBD), and its pathogenesis is not completely resolved. We investigated whether bone mineral density (BMD) in patients with IBD at diagnosis is lower than in population controls, and whether BMD differs …
Reduction in diversity of the colonic mucosa associated bacterial microflora in patients with active inflammatory bowel disease
Publication Year: 2004 Source: Gut PMID: 15082587 DOI: 10.1136/gut.2003.025403
BACKGROUND: In acute or chronic inflammatory bowel disease (IBD) interferon gamma (IFNgamma) is still considered to be an important pro-inflammatory mediator. In the present study we investigated the impact of IFNgamma on interleukin-8 (IL-8) production as a read-out for cell activation in intestinal epithelial cell (IEC) lines and primary human …
Expression of apoptosis-related proteins in rat with induced colitis
Publication Year: 2004 Source: Int J Colorectal Dis PMID: 15083321 DOI: 10.1007/s00384-004-0585-5
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IBD or IBS: when there is abdominal pain, does it really matter?
Publication Year: 2004 Source: J Pediatr Gastroenterol Nutr PMID: 15085031 DOI: 10.1097/00005176-200404000-00020
AIM: To study the response to infliximab in pediatric inflammatory bowel disease (IBD), as reflected in fecal calprotectin levels. METHODS: Thirty-six pediatric patients with IBD [23 Crohn's disease (CD), 13 ulcerative colitis (UC); median age 14 years] were treated with infliximab. Fecal calprotectin was measured at baseline, and 2 and …
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