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The chronic colitis developed by HLA-B27 transgenic rats is associated with altered in vivo mucin synthesis
Publication Year: 2004 Source: Dig Dis Sci PMID: 15104381 DOI: 10.1023/b:ddas.0000017462.75257.70
Proinflammatory cytokines released from monocytes/macrophages, in particular tumor necrosis factor (TNF)-alpha, interleukin (IL)-1, IL-6, and IL-8 seem to play an important role in Inflammatory Bowel Disease (ulcerative colitis and Crohn's disease). Endotoxins or lipopolysaccharides, derived from the outer membrane of Gram-negative bacteria interact with CD14 on surface membrane of macrophages, …
[Bone metabolism in 53 children and adolescents with chronic inflammatory bowel disease]
Publication Year: 2004 Source: Klin Padiatr PMID: 15106075 DOI: 10.1055/s-2004-823145
Tissue accumulation of polymorphonuclear neutrophils (PMN) in Inflammatory Bowel disease (IBD) might be, in part, due to a delay in apoptotic processes associated with the effects of their specific growth factors and inflammatory cytokines. We addressed this hypothesis by examining the activity of granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage CSF …
Strategies for detecting colon cancer and/or dysplasia in patients with inflammatory bowel disease
Publication Year: 2004 Source: Cochrane Database Syst Rev PMID: 15106148 DOI: 10.1002/14651858.CD000279.pub2
BACKGROUND & AIMS: There are limited data on mortality from colorectal cancer (CRC) among patients who have received colonoscopy examinations. We sought to determine CRC mortality among persons undergoing colonoscopies compared with the general population. METHODS: We identified all individuals who had a colonoscopy as their first lower gastrointestinal endoscopy …
Genetic variation in DLG5 is associated with inflammatory bowel disease
Publication Year: 2004 Source: Nat Genet PMID: 15107852 DOI: 10.1038/ng1345
OBJECTIVES: To estimate the prevalence of inflammatory bowel disease (IBD) from the information in general practitioners' records and to describe patient management, including the prescribing of 5-aminosalicylates and adherance to treatment in ulcerative colitis, and frequency of advice given concerning cessation of smoking. METHODS: Fifteen general practices were recruited through …
Immunoassays of human trefoil factors 1 and 2: measured on serum from patients with inflammatory bowel disease
Publication Year: 2004 Source: Scand J Clin Lab Invest PMID: 15115253 DOI: 10.1080/00365510410001176
BACKGROUND: In recent years, several case reports have been published suggesting an association between the use of 5-aminosalicylic acid (5-ASA) in patients with inflammatory bowel disease (IBD) and the development of chronic tubulo-interstitial nephritis. Apart from lesions associated to 5-ASA treatment, however, it is clear that IBD itself may also …
Diverticulitis and IBD
Publication Year: 2004 Source: J Clin Gastroenterol PMID: 15115924 DOI: 10.1097/01.mcg.0000124004.07433.20
Not found
Pathology of indeterminate colitis
Publication Year: 2004 Source: J Clin Gastroenterol PMID: 15115930 DOI: 10.1097/01.mcg.0000127686.69276.5b
The reverse transcriptase-polymerase chain reaction/restriction fragment length polymorphism (RT-PCR/RFLP) technique was used for identification and characterization of Egyptian field strains of infectious bursal disease viruses (IBDVs) that caused severe outbreaks with (30%-60%) mortality rate. Twenty-four bursal samples collected from 24 field outbreaks in commercially reared chicken flocks experiencing signs typical …
Do serological markers and cytokines determine the indeterminate?
Publication Year: 2004 Source: J Clin Gastroenterol PMID: 15115933 DOI: 10.1097/01.mcg.0000124026.92823.fc
The assessment of inflammatory activity in intestinal disease in man can be done using a variety of different techniques, from measurement of conventional noninvasive acute-phase inflammatory markers in plasma (C-reactive protein and the erythrocyte sedimentation rate) to the direct assessment of disease activity by intestinal biopsy. However, most of these …
Faecal calprotectin: a new marker for Crohn's disease?
Publication Year: 2004 Source: Ann Clin Biochem PMID: 15117438 DOI: 10.1258/000456304323019613
Not found
Thiopurine methyltransferase activity influences clinical response to azathioprine in inflammatory bowel disease
Publication Year: 2004 Source: Clin Gastroenterol Hepatol PMID: 15118980 DOI: 10.1016/s1542-3565(04)00127-2
INTRODUCTION: ALPHA-GAL is a glycoconjugate present on cell membranes of mammals and bacteria but not humans who display anti-Gal antibodies (AB) in high titers provoked by the commensal gut flora. In the present study, we sought to determine the longitudinal course of alpha-Gal specific AB titers of all isotypes over …
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