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Therapeutic manipulation of the enteric microflora in inflammatory bowel diseases: antibiotics, probiotics, and prebiotics
Publication Year: 2004 Source: Gastroenterology PMID: 15168372 DOI: 10.1053/j.gastro.2004.03.024
Comment in Inflamm Bowel Dis. 2003 Sep;9(5):341. OBJECTIVES: Single nucleotide variations in the CARD15 gene have recently been shown to be associated with Crohn's disease (CD). Of special interest is a cytosine insertion at position 3020 of exon 11 (3020insC), which leads to a stop codon, truncation of the CARD15 …
Gadolinium-enhanced magnetic resonance imaging: a useful radiological tool in diagnosing pediatric IBD
Publication Year: 2004 Source: Inflamm Bowel Dis PMID: 15168803 DOI: 10.1097/00054725-200403000-00001
BACKGROUND: Health-related quality of life (HRQOL) has become an important tool in evaluating patient satisfaction in inflammatory bowel disease (IBD). So far, few prospective follow-up studies have been done to identify variables that influence HRQOL. We aimed to identify demographic and clinical variables that influence HRQOL 5 years after diagnosis …
Basic epidemiology of inflammatory bowel disease in Puerto Rico
Publication Year: 2004 Source: Inflamm Bowel Dis PMID: 15168809 DOI: 10.1097/00054725-200403000-00007
OBJECTIVE: An inappropriate mucosal immune response to the commensal bacterial flora may play a role in the pathogenesis of inflammatory bowel disease (IBD). In this study we determined the percentage of immunoglobulin-coated bacteria in the stools of patients and controls. METHODS: Faecal samples were obtained from 18 patients with IBD …
Ocular manifestations of inflammatory bowel disease
Publication Year: 2004 Source: Inflamm Bowel Dis PMID: 15168814 DOI: 10.1097/00054725-200403000-00012
The aim of this research was to determine the importance of tracking the dynamics of changes of the hemostatic system factors (aggregation of thrombocytes, D-dimer, PAI-1, antithrombin III, protein C and protein S, factor VII and factor VIII, fibrin degradation products, euglobulin test and th activated partial thromboplastin time--aPTPV) in …
New endoscopic tools for the IBD physician
Publication Year: 2004 Source: Inflamm Bowel Dis PMID: 15168823 DOI: 10.1097/00054725-200402001-00002
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Genetic origin of IBD
Publication Year: 2004 Source: Inflamm Bowel Dis PMID: 15168824 DOI: 10.1097/00054725-200402001-00003
Comment on Nat Genet. 2000 Dec;26(4):398-9. Busjahn et al reported finding linkage between PPARG (3p25) and being a dizygotic (DZ) twin. We differentiate, as do the authors, between the conception of DZ twins, and being the viable result of such a conception.
The epidemiology of IBD: a lot of data but little knowledge. How shall we proceed?
Publication Year: 2004 Source: Inflamm Bowel Dis PMID: 15168828 DOI: 10.1097/00054725-200402001-00007
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Pharmacogenomics and IBD: TPMT and thiopurines
Publication Year: 2004 Source: Inflamm Bowel Dis PMID: 15168829 DOI: 10.1097/00054725-200402001-00008
Primary sclerosing cholangitis is a cholestatic liver disease strongly associated with IBD. Considerable advances in the understanding of its pathogenesis have been made. The idea of autoimmunity affecting genetically susceptible individuals is largely accepted; however, much remains to be explained about the origin of this disease. Despite active investigation of …
Innate immunity and apoptosis in IBD
Publication Year: 2004 Source: Inflamm Bowel Dis PMID: 15168833 DOI: 10.1097/00054725-200402001-00012
Substantial progress has been made in the last years in characterizing the susceptibility genes involved in IBD pathogenesis, especially for Crohn's disease. Although some genetic factors associated with Crohn's disease also predispose individuals to ulcerative colitis, markers specific only for ulcerative colitis have been found. Recent genome-wide association studies in …
Using identity-by-descent information in affected sib pairs to increase the efficiency of genetic association studies
Publication Year: 2004 Source: Twin Res PMID: 15169605 DOI: 10.1375/136905204323016195
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