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IBD: a family affair
Publication Year: 2004 Source: Best Pract Res Clin Gastroenterol PMID: 15157825 DOI: 10.1016/j.bpg.2003.12.006
Arthropathies are a major clinical problem in patients with inflammatory bowel disease (IBD). Often it is difficult to control the articular symptoms with the anti-inflammatory strategies used for IBD. Studies evaluating specific treatments aimed at articular manifestations in patients with IBD are rare. Although there has been considerable interest in …
Genome scan analyses and positional cloning strategy in IBD: successes and limitations
Publication Year: 2004 Source: Best Pract Res Clin Gastroenterol PMID: 15157826 DOI: 10.1016/j.bpg.2003.12.007
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The contribution of HLA genes to IBD susceptibility and phenotype
Publication Year: 2004 Source: Best Pract Res Clin Gastroenterol PMID: 15157829 DOI: 10.1016/j.bpg.2004.01.003
Leptin, a peptide encoded by the obese (ob) gene, is primarily secreted by adipocytes and is a critical hormone that controls body weight due to its central effects. Recently, additional roles for leptin in the gastrointestinal tract have been suggested because gastric lining cells also produce and release leptin in …
Female infertility after ileal pouch-anal anastomosis for ulcerative colitis
Publication Year: 2004 Source: Dis Colon Rectum PMID: 15164254 DOI: 10.1007/s10350-004-0570-7
OBJECTIVE: To determine the incidence of small bowel obstruction (SBO), to identify risk factors for its development, and to determine the most common sites of adhesions causing SBO in patients undergoing ileal pouch-anal anastomosis (IPAA). METHODS: All patients undergoing IPAA at Mount Sinai Hospital were included. Data were obtained from …
Pharmacokinetics of 6-mercaptopurine in patients with inflammatory bowel disease: implications for therapy
Publication Year: 2004 Source: Ther Drug Monit PMID: 15167634 DOI: 10.1097/00007691-200406000-00016
Short-chain fatty acids (SCFA) are produced by fermentation of water-soluble fiber by anaerobic bacteria in the large bowel. Fiber-rich diets decrease the risk of developing inflammatory bowel disease (IBD) and butyrate enemas are effective as a therapy in some patients. Crohn's disease, one form of IBD, appears to involve an …
From symptom to diagnosis: clinical distinctions among various forms of intestinal inflammation
Publication Year: 2004 Source: Gastroenterology PMID: 15168364 DOI: 10.1053/j.gastro.2004.02.072
The better understanding of the mechanisms of inflammatory bowel disease has driven our progress into the development of new biological therapies targeting specific molecules. Anti-TNF-alpha biologic compounds have shown great efficacy particularly in Crohn's disease. Infliximab (an IgG1 mouse/human chimeric monoclonal anti-TNF-alpha antibody fragment) is the most efficacious compound in …
Clinical relevance of advances in genetics and pharmacogenetics of IBD
Publication Year: 2004 Source: Gastroenterology PMID: 15168365 DOI: 10.1053/j.gastro.2004.01.061
MMR is a live attenuated vaccine. Indian children show almost 90% seroconversion against measles and rubella and 90% against mumps. Several adverse effects have been reported. Epidemiological studies do not support a causative link between MMR and autism, IBD or GBS. There is an association between the Urabe strain of …
Endoscopy in inflammatory bowel diseases
Publication Year: 2004 Source: Gastroenterology PMID: 15168367 DOI: 10.1053/j.gastro.2004.03.023
Crohn's disease and ulcerative colitis result from an inappropriate response of the mucosal immune system to the normal enteric flora in a genetically susceptible individual. During the past decade, exciting progress has been made in our understanding of the contribution of genetics to inflammatory bowel disease susceptibility and phenotype. This …
Optimizing anti-TNF treatment in inflammatory bowel disease
Publication Year: 2004 Source: Gastroenterology PMID: 15168370 DOI: 10.1053/j.gastro.2004.02.070
BACKGROUND: Enhanced expression of MAdCAM-1 (mucosal addressin cell adhesion molecule-1) is associated with the onset and progression of inflammatory bowel disease. The clinical significance of elevated MAdCAM-1 expression is supported by studies showing that immunoneutralization of MAdCAM-1, or its ligands reduce inflammation and mucosal damage in models of colitis. Interleukin-10 …
Current concepts and controversies in surgery for IBD
Publication Year: 2004 Source: Gastroenterology PMID: 15168371 DOI: 10.1053/j.gastro.2004.03.063
Advances in genetic testing have confirmed the presence of susceptibility loci on chromosomes 12 and 16 for UC and CD. These loci show a strong association with particular disease phenotypes that may explain the clinical heterogeneity of IBD. Whether multiple genotypes will be found to explain these phenotypes remains to …
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